Global ETD Search
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Showing 1 to 3 of 3 for “"saposins"”.
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Structural and Functional Studies of the Human Saposin Proteins
The human saposins are four homologous activator proteins that are essential for the lysosomal degradation of sphingolipids (SLs) with small headgroups. They function in part to increase the solvent accessibility of these SLs to specific acid hydrolases by two proposed modes of action. In the …
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Modelling saposin deficiency in Drosophila: progressive neurodegeneration, storage and physiological decline
… gene, which encodes 4 activator proteins: saposins A - D. Mutations affecting individual saposins lead to different LSDs. Therefore, modelling saposin deficiency in Drosophila provides great scope for understanding childhood neurodegeneration. The Drosophila prosaposin homologue is the …
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Protein-sphingolipid interactions and their role in immunity and disease
Sphingolipids are a diverse class of lipids involved in fundamental cellular processes. In addition to their role in membrane architecture, sphingolipids can act as bioactive molecules, regulate membrane protein function and be presented to the immune system as lipid antigens by CD1 family …