Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"salt sensitivity"”.
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Effect Of Dimethylarginine Dimethylaminohydrolase In The Development Of Salt Sensitivity
<p>Salt sensitivity is associated with a rise in blood pressure (BP) occurring during sodium loading and/or a fall in BP during sodium restriction that exceeds random fluctuations in BP. Salt sensitivity is more common in African American than Caucasian hypertensives and is also present, in …
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Investigating the Influence of NEDD4L in the Development of Salt Sensitive Hypertension with Age
… influenced by both the environment and genetics. Salt sensitivity is described at higher rates in the hypertensive population. The NEDD4-like (NEDD4L) protein is important in sodium reabsorption and has been implicated in essential hypertension and salt sensitivity. Objectives: Two variations …
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Maternal High-Salt Diet During Pregnancy in Sprague Dawley Rats Programs Exaggerated Stress-Induced Blood Pressure and Heart Rate Responses in Adult Female Offspring
… study, pregnant rats were fed a 0.7% NaCl normal salt (NS) diet or an 8% NaCl high salt (HS) diet throughout pregnancy. Adult offspring were fitted with radiotelemetry probes to continuously measure blood pressure and heart rate. Rats were placed in restraining cages to test for a programmed acute …
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Functional Characterization of the Mammalian TRPV4 Channel: Yeast Screen Reveals Gain-of-Function Mutations
… yeast low-potassium growth, as well as degree of salt sensitivity conferred on wild type yeast. We also performed two-electrode voltage-clamp (TEVC) recordings of the mutant channels expressed in Xenopus oocytes, obtaining preliminary data on the ability of the mutations to restore a …
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Genetic Predictors of Hyperglycemia Due to Hydrochlorothiazide Therapy
… renin-angiotensin-aldosteron system (RAAS) and salt–sensitivity genes) have met with only limited success.</p> <p>We conducted the first genome wide association study to identify genes influencing hyperglycemia as an adverse effect of thiazide diuretics in non-Hispanic White hypertensive …
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Neural mechanisms promoting G-alpha-i2 protein dependent salt sensitive hypertension in the Sprague-Dawley rat
… to 10% of deaths worldwide. Additionally, the salt sensitivity of blood pressure, an exaggerated pressor response to elevated dietary sodium intake, is estimated to be present in approximately 50% of the hypertensive population and 25% of the normotensive population. This is a critical problem …
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Toward improved assessment of freshwater salinization as a benthic macroinvertebrate stressor
… human activities is of growing concern globally. Salt pollution can cause adverse effects to aquatic biodiversity, ecosystem function, ecosystem services, and human health. In many regions of the world, and in coal-mining-influenced streams of the temperate forests of Appalachia USA, specific …
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Fundamental study of natural and synthetic antimicrobial peptides as novel preservatives against fungal food spoilage
… activity against F. culmorum hyphae, but suffer salt sensitivity. Mechanistic studies reveal membrane permeabilization and overgeneration of reactive oxygen species. The potential of the peptides for food applications has been exploited either with a recombinant yeast, able to express a …
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Autoinhibition and Chloride Sensing in the WNK1 Kinase
… by increasing con- centrations of extracellular salt and by intracellular phosphorylation from the OSR/SPAK kinases. Due to it ubiquity in mammalian cell types, a question has arisen as to how the pathway responds to changes in osmolarity. Further, because of the involvement of WNK1 in a diverse …