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Showing 1 to 2 of 2 for “"salarin C."”.
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Pharmacophore-directed retrosynthesis (PDR) and Density functional theory studies applied to the potent ion channel inhibitor waixenicin A : synthetic studies toward a more stable salarin C congener, thia-salarin C, through the lens of PDR.
… also applied to the potent anti-cancer macrolide salarin C (SalC). SalC is one of ten congeners of this marine natural product family but shows the highest potency towards myeloid leukemia cells (IC50=5 nM) however, the mode of action is currently unknown, making it an ideal target for concurrent …
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Understanding the singlet oxygen reactivity of salarin C through synthesis of a simplified macrocyclic analogue; multicomponent, enantioselective organocatalytic synthesis of tetrahydropyridazinones.
… cytotoxic chemical defense agents. The macrolide salarin C is one of those cytotoxic sponge natural products, isolated from a Madagascar sponge. Of particular interest is the marked reactivity of its oxazole moiety with singlet oxygen that converts salarin C to its biologically inactive congener, …