Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"saccharin"”.
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Age-related differences in taste aversion learning: preexposure to the conditioned stimulus through suckling
Rat pups (Rattus Norvegicus) were exposed to saccharin through suckling dams whose drinking water had been adulterated during lactation. Behavioral evidence is reported that the saccharin penetrated the milk and was detectable by the pups. Preexposure to saccharin did not influence the effects of …
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Dietary supplementation of saccharin-based artificial sweeteners and capsicum oleoresin as a strategy to mitigate the negative consequences of heat stress on pig growth performance and intestinal physiology
… and permeability also result from hyperthermia. Saccharin-based artificial sweeteners have the potential to ameliorate the negative effects of heat stress (HS) by increasing GI GLP-2 production while capsicum oleoresin has been shown to reduce inflammatory response. Study objectives were to …
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Immunological and behavioral consequences of high-fat diet feeding in mice
… in consuming a highly palatable sucrose or saccharin solution. Here we show that obese mice fed a high-fat diet (HFD), fail to exhibit an interest in saccharin (27% vs 74%) compared to mice fed a low-fat diet (LFD) (p < 0.007). When HFD mice undergo a fasting period of 24 hours, saccharin …
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Prenatal Intravenous Nicotine Exposure: Increased Motivation For Methamphetamine Self-Administration, Altered Methamphetamine-Induced Locomotor Activity and Brain-Derived Neurotrophic Factor Protein Levels In Adult Rats
… trials. After the preexposure phase, METH-saccharin pairings occurred for 3 consecutive days. Following conditioning trials, animals were administered a 2-bottle saccharin preference test. And for 7 days following the 2-bottle test, 1-bottle saccharin extinction trials occurred. It was …
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The Effect of Us-Preexposure On Meth-Induced Cta In Periadolescent and Young Adult Rats
… trials. After the preexposure phase, METH-saccharin pairings occurred for 3 consecutive days. Following conditioning trials, animals were administered a 2-bottle saccharin preference test. And for 7 days following the 2-bottle test, 1-bottle saccharin extinction trials occurred. It was …
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Determination of Organic Compounds by Atomic Absorption Spectrophotometry (AAS) with Special Reference to Compounds Encountered in Environmental Problems
… to demonstrate the feasibility of the method. Saccharin, an important artificial sweetener, and common food additive, may be determined by atomic absorption spectroscopy via complexation as its tris-(1,10-phenanthroline)iron(II) cation. The other subject chosen for study was the possible …
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Effects of pre-exposure concentration in neophobia and taste aversion learning
Rats received access to high or low saccharin concentrations or to distilled water or 2% saline prior to testing for conditioned taste aversion or neophobia. Pre-exposure to high saccharin concentration attenuated neophobia and taste aversion to high and low concentrations. Pre-exposure to the low …
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ELECTROCHEMICAL SYNTHESIS OF MAGNETIC MATERIALS FOR MAGNETIC RECORDING AND MEMS APPLICATIONS
… this purpose. Sulfur containing additives like saccharin are incorporated in the CoFe electrodeposition bath to provide desirable properties like low stress, low coercivity and fine grain size to the deposit. The effect of saccharin incorporation during electrodeposition process on the …
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Novel Methods for Co-crystallisation
… for co-crystallisation of carbamazepine / saccharin co-crystal pair and demonstrated its application for polymorphic control and as a potential technique for the purification of desired crystal form through surface energetic based separation. The thermodynamic interrelationship between Form …
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Structural investigations with high pressure techniques and multicomponent systems
… pharmaceutical co-crystal, indomethacin and saccharin was analysed with respect to increasing pressure. The system is an example of a homomolecular synthon co-crystal allowing investigation of the component dimers free of strong interaction with surrounding molecules. The ambient pressure …
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Advancing structural applications of nickel electrodeposition onto additively manufactured polymers
… advantages. Evaluations of additive-free and saccharin-enhanced Watts electrolytes demonstrate that saccharin significantly improves surface smoothness, reduces porosity, enhances hardness to over 550 HV, and increases tensile strength up to 800 MPa, although with increased brittleness address …
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Effects of Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin or Coplanar PCBs on Reproductive Development and Sexually Dimorphic Behaviors in Rats
… they did not appear in the follow-up study. Saccharin preference of the TCDD and coplanar PCBs exposed females was masculinized in both studies. TCDD and PCBs have antiestrogenic effects and masculinization of saccharin preference in females could be due to the antiestrogenic effects of these …
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Identifying dietary additive regulated mechanisms impacting intestinal epithelial cell responses and inflammatory processes
… sweeteners tested—Psicose, Lactitol, Maltitol, Saccharin, and Tagatose—saccharin shows a significant impact on gene expression, particularly under inflammatory conditions. Saccharin activates JAK/STAT pathway related to inflammation by increasing cytokine secretion and cell death, indicating a …
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Acute Impact of Non-Sugar Sweeteners on Glycemia in Middle-Aged and Older Adults with Prediabetes
… but no NSS), while the second study compared saccharin and acesulfame potassium (Ace-K) to the same control condition. Sucralose had a significant effect on glucose (13±4 mg/dL; p=0.017) but no impact on insulin concentrations compared to control (0.4±6.5 mg/dL), while aspartame did not exert …
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An examination of the effects of the catalase inhibitor 3-amino-1,2,4-triazole on ethanol, food and water intake
… containing a concentration of 0.6% w/w sodium saccharin was preferred over a neutral-flavoured food while a concentration of 0.15% w/w of quinine sulfate was less preferred. These two concentrations of saccharin and quinine were used in experiment 1B to study the effects of AT on taste …
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Development of cocrystals of water insoluble active substances with inactive excipients by using hot melt extrusion
… a poorly water soluble drug, carbamazepine, with saccharin and trans-cinnamic acid, were produced by using single (SSE) and twin screw (TSE) hot melt extrusion. The optimum barrel temperature for TSE was chosen from various temperature profiles applied in the SSE experiments. Physicochemical …
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Spectroscopic and Microscopic Investigation of Electrochemical Interfaces
In addition, the adsorption of saccharin on a copper electrode was studied with electrochemical methods, surface-enhanced Raman spectroscopy, and in-situ STM measurements. The results of electrochemical studies of the interaction of sodium saccharinate and chloride as additives on the copper …
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Investigating Factors Underlying the Ability of Reward-Paired Cues to Function as Conditioned Reinforcers
… the effects of reducing the reward value of saccharin on responding for a saccharin-paired CRf. Results showed that responding was not altered by saccharin devaluation. This raised the question of how drug-associated stimuli motivate drug use if they do so in a manner that is divorced from …
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Neuroendocrine mechanisms of behavioral changes induced by hypoglycemia
… causes anhedonia and depressive-like behavior. Saccharin preference testing 24h post hypoglycemia showed that mice receiving insulin (0.8 units/kg) had saccharin aversion (62% vs 90.5% of total fluid consumption). In addition, mice administered insulin had increased immobility in the forced swim …
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Leptin Action on Dopamine Neurons: Biochemical and Behavioral Analysis
… evidence also suggests a role for Lepr in saccharin and cocaine seeking behaviors. Rats with attenuated Lepr signaling in the VTA demonstrate persistent saccharin and cocaine seeking. Conversely, leptin infusions reduced lever pressing during drug withdrawal. These results are indicative of …
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