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Showing 1 to 20 of 38 for “"saccharide"”.
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Controlling Microbial Multicellular Behaviors With Saccharide Derivatives
… antibiofilm approach of using nonmicrobicidal saccharide derivatives for controlling the multicellular behaviors of gram-negative bacteria, Pseudomonas aeruginosa and fungus, Candida albicans.</p> <p>Pseudomonas aeruginosa is known to secrete rhamnolipids, a class of biosurfactants that plays …
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Saccharide recognition : boronic acids as receptors in polymeric networks
In this thesis entitled “Saccharide Recognition - Boronic acids as Receptors in Polymeric Networks” different aspects of boronic acid synthesis, their analysis and incorporation or attachment to different polymeric networks and characterisation thereof were investigated. The following key aspects …
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Isolation and Evaluation of the Saccharide Components of Starch Hydrolyzates
Made available in DSpace on 2014-12-05T19:06:52Z (GMT). No. of bitstreams: 1 6305102.pdf: 4192354 bytes, checksum: 909d0bff1c044e0de315e5b97b2b2c1e (MD5) Previous issue date: 1963
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Modellverbindungen zum Studium Sialinsäure-vermittelter Erkennungsprozesse : Synthese neuer Saccharide auf Basis von Carotinoiden und Furanen
… Die Kopplungen zwischen den jeweiligen Sacchariden und Carotinoiden erwiesen sich als problematisch: Weder durch direkte Glycosilierung noch durch eine Amidbildung oder eine Wittig-Horner-Reaktion konnten entsprechende Konjugate aus Carotinoiden und Sacchariden erhalten werden. Im …
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Physicochemical studies of a novel adjuvant and conjugate vaccines
… which Haemophilus influenzae type b capsular polysaccharide (polyribosylribitolphosphate or PRP) is conjugated to a carrier protein. The conjugate is immunogenic in infants who have a higher risk of infection while the polysaccharide vaccine is not. The compatibility of the Hib antigenic component …
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Part I. Cleavage of Carbamates to Isocyanates: Selectivity, Extension to the Solid Support, and Synthesis of Multivalent Glycoforms With Inter-Saccharide Carbamate Linkages. Part II. Conjugation of Carbohydrate Moieties to a Rigid Aromatic Linker for the Study of Glycoside Internal Dynamics
… moieties that will allow conjugation of a saccharide to a protein is reported. This approach was demonstrated in the synthesis of the saccharide-linker moieties of the four glucopyranosyl-beta-D-glucopyranosides. The results show that disaccharides with varying glycosidic linkage positions …
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ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΤΗΣ ΓΛΥΚΟΛΙΠΟΠΡΩΤΕΙΝΗΣ (G.L.P.) ΤΟΥ SLIME ΤΡΙΩΝ ΠΡΟΤΥΠΩΝ ΣΤΕΛΕΧΩΝPSEUDOMONAS AERUGINOSA ΚΑΙ ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ ΑΥΤΗΣ ΩΣ ΠΡΟΣ ΤΙΣ ΟΜΟΙΟΤΗΤΕΣ Η ΤΙΣ ΔΙΑΦΟΡΕΣ ΜΕ ΤΟ ΛΙΠΟΠΟΛΥΣΑΚΧΑΡΙΤΗ (L.P.S.) ΤΟΥ ΜΙΚΡΟΟΡΓΑΝΙΣΜΟΥ
LIPOPOLYSACCHARIDE (LPS) SLIME AND OUTER MEMBRANES WERE OBTAINED FROM A SMOOTH NON MUCOID PSEUDOMONAS AERUGINOSA STRAIN PAC-IR AND ITS TWO ROUGH MUTANTS PAC 557 AND PAC 605. ELECTROPHORETIC ANALYSIS ON SDS- POLYACRYLAMIDE GELS AND STRAINING WITH SILVER AND COOMASSIE BLUE SHOWED DIFFERENT PROFILES …
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Synthesis and characterization of transition metal nitrides and carbides for catalysis and electrochemistry application
… of the thesis is focusing on the use of the “saccharide route” (namely cellulose, sucrose, glucose and lignin) towards metal (Ni0), metal alloy (Pd0.9Ni0.1, Pd0.5Ni0.5, Fe0.5Ni0.5, Cu0.5Ni0.5 and W0.15Ni0.85) and ternary carbide (Mn0.75Fe2.25C) nanoparticles embedded in carbon. In the interest …
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Protection Mechanisms of Excipients on Lactate Dehydrogenase during Freeze-Thawing and Lyophilization
… dissertation, different molecular weights of saccharides, e.g., glucose, sucrose, dextran 37000 (D 37K) and dextran 160000 (D 160K) with or without PEG 8000, were formulated with LDH at various molar ratios. LDH tetrameric structures were destabilized and activity was lost more when dextrans …
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Investigating the pathway of asparagine-linked glycoprotein biosynthesis
… requires a dolichylpyrophosphate-linked tetradecasaccharide precursor (Dol-PP-GlcNAc2Man9Glc3), from which the tetradecasaccharide is transferred co-translationally to nascent polypeptides in the lumen of the ER by the multimeric membrane-bound enzyme, oligosaccharyl transferase (OT). The …
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DEVELOPMENT AND CHARACTERIZATION OF NOVEL MONOCLONAL ANTIBODIES TARGETING CARBOHYDRATE ANTIGENS IN CANCER
… novel monoclonal antibodies targeting saccharide antigens. Here we show PD-1-/- mice on a C57BL/6 background can be used to generate an immunogenic response to desialylated bovine submaxillary mucin (dBSM). From these we produced anti-GlcNAc (N-Acetyl-D-Glucosamine) and anti-GalNAc …
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Comparative evaluation of two carbohydrate force fields for modelling polysaccharide conformation
… conformational predictions of rhamnose-rich polysaccharides between GLYCAM06 and other widely used carbohydrate force fields. This thesis investigates the scope and origin of these differences. We compare Molecular Dynamics simulations of strategically selected saccharide chains, with both the …
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STUDIES ON COMPLEX FORMATION BY HEPARIN
… which included the analysis of elements, saccharide components, and biological and chemical assays. The bioactivity of this compound has been determined using both in. vivo and in vitro assays. In addition the effects of cations on the mobility of heparin were studied using …
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MOLECULAR MODELING STUDIES OF HEPARIN AND HEPARIN MIMETICS BINDING TO COAGULATION PROTEINS
… respectively. The sequence specific pentasaccharide DEFGH in full length heparin is the most important fragment for high affinity and activation of antithrombin, without which the heparin is incapable of binding to antithrombin. Although heparin is a commonly used anticoagulant, it suffers …
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A computational study of acidic Ionic Liquids for cellobiose hydrolysis in ionic liquids
… Glucose generation from cellulose requires a saccharide conversion, whereby the β-(1,4)-glycosidic bond linkages in the cellobiose polymer repeating units are cleaved. Problems arise in the hydrolysis of cellulose as experimental and theoretical studies have shown cellulose to have very low …
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Synthese von multivalenten Saccharidmimetika als Liganden für Zellmembran-Lectine und als Inhibitoren der Zelladhäsion und Invasion
… Zelladhäsion und Migration. Verzweigte Saccharide zeigen eine höhere Bindungsaffinität als lineare. Daher wurde im Rahmen dieser Arbeit zwei Typen von di- und trivalenten Saccharidmimetika, die sich in ihrer Corestruktur unterscheiden, synthetisiert, um ihre biologische Aktivität im …
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Molecular modelling of the Streptococcus pneumoniae serogroup 6 capsular polysaccharide antigens
… structural characterization of the capsular polysaccharides of Streptococcus pneumoniae is conducted using Molecular Modelling methods. S.pneumoniae causes invasive pneumococcal disease (IPD), a leading cause of death in children under five. The serotypes in group 6 are amongst the most common of …
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Synthesis and Antifungal Evaluation of Barbiturate Saponins And Progress Towards Cysteinyl Metal Peptides
… under basic conditions to synthesize mono and disaccharide barbiturates. Saccharide molecules were directly introduced into the barbiturate without requiring protection and deprotection of saccharides. Efficient methods were developed for synthesis of 3<em>β</em> derivatized steroid derivatives …
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Impact of Oxygen and Pesticides on Microbial Cellulose Degradation in Aerated Agricultural Soils: A Microscaled Analysis of Processes and Prokaryotic Populations
The polysaccharide cellulose is a major component of organic matter in terrestrial ecosystems and its mineralization drives carbon fluxes in soil. The degradation of plant-derived saccharides (e.g., cellulose, cellobiose, and glucose) is catalysed by a huge diversity of aerobic and anaerobic …
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