Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"sPLA2"”.
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Phospholipase A2 Induced Monocyte Chemotaxis to Apoptotic Cells
… report suggests that the secreted group IIa (sPLA2) binds to surfaces of apoptotic cells. The "receptor" for this pool of sPLA2 is the rod domain of vimentin, an intermediate filament protein that is exposed by caspase activity when cells undergo apoptosis. Based on these observations, we …
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Mechanism Governing the Cellular Susceptibility to Secretory Phospholipase A2
Secretory phospholipase A2 (sPLA2) is an important part of apoptosis and disposal of damaged and dying cells. However, healthy cells are not susceptible to attack by sPLA2. Recent studies have focused on membrane properties necessary to induce susceptibility in both artificial and biological …
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Mechanisms by Which Apoptotic Membranes Become Susceptible to Secretory Phospholipase A2
… to hydrolysis by secretory phospholipase A2 (sPLA2). To study the relevant mechanisms, a simplified model of apoptosis using a calcium ionophore was first applied. Kinetic and flow cytometry experiments provided key observations regarding ionophore treatment: initial hydrolysis rate was …
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Mouse modifiers of intestinal tumorigenesis
… gene, the group IIA secretory phospholipase a2 (sPLA2-IIA). Only tumor prone Mom1 strains, such as B6, contain a mutation in sPLA2-IIA abolishing expression. In order to rigorously measure the effect of sPLA2-IIA on the Apdmin tumor phenotype, we have created and analyzed transgenic lines that …
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Interaction of sPLA2 phospholipases with assemblies of natural and synthetic amphiphiles and the development of a drug delivery system for the treatment of breast cancer
… the phospholipids. Secreted phospholipases A2 (sPLA2) are the cell-secreted PLA2s ubiquitously present throughout the body. The sPLA2s are smaller in size and structurally sturdier than their PLA2 congeners due to the presence of several disulfide bonds in their tertiary structure. These enzymes …
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Regulation of Secretory Phospholipase A2 by Thyroid Hormone
… inflammation led us to examine the modulation of sPLA2 expression by thyroid hormone (T3) in liver.</p> <p>Objective: Most of the studies of phospholipase A2 group IIA (PLA2g2a) have been conducted with macrophages and vascular smooth muscle cells with regard to atherosclerosis. The liver is one …
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Caracterización de las vías de la fosfolipasa A_2 en procesos de neurodegeneración inducidos por estrés oxidativo en la retina bovina
… de calcio (iPLA2) y la isoforma secretoria (sPLA2), durante la toxicidad retiniana inducida por Fe2+. También analizamos las implicancias de las diferentes PLA2s en la regulación de la ciclooxigenasa (COX)-2, el factor de transcripción nuclear kappa B (NF-κB, del inglés nuclear factor kappa …
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Phospholipase A 2 in der Parvovirus MVMp induzierten Zelllyse
… A2 (PLA2) Enzyme, die in sekretorische sPLA2, zytosolische cPLA2 und Ca2+-unabhängige iPLA2 unterteilt werden, aus den folgenden Gründen für diesen Zusammenhang von Bedeutung sein könnten. Zum einen sind sie als Phospholipidhydrolasen, neben der Produktion von Lipidsignalmediatoren, auch …
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Influence of climate changes on cross allergies: possible involvement of pollen transglutaminase
… modified, as well as mammalian sPLA2 especially with Corylus pollen, which results in its activation, potentially altering pollen allergenicity and inflammation. Pollen TGase activity mimicked the behaviour of gpl TGase and AtPNG1p in the stimulation of sPLA2, even if the …
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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism
… role of different secretory phospholipase A2s (sPLA2) in metabolic diseases. From these studies, it is known that at least seven of the 11 sPLA2 isozymes contribute to the prevention or causation of metabolic diseases such as obesity and Type 2 diabetes. Increased energy expenditure, insulin …
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Neuroglial Mechanisms Involved In The Anti-Inflammatory Effect Of Acetate Supplementation
… ERK1/2 and NF-κB p65 at serine 536, sPLA2 IIA and PLCβ1. Acetate treatment also increased acetylated H3K9 bound to the promoters of the genes of Cox-1, Cox-2, IL-1β and NF-κB p65, but not IL-4 in BV-2 microglia, which suggests that acetate treatment-induced H3K9 hyperacetylation can …