Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"sMCS"”.
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Charakterisierung der Lebensgewohnheiten und des Lebensumfeldes von Patienten mit selbstberichteter Multipler Chemikaliensensitivität (sMCS)
… factors of persons with self-reported MCS (sMCS) in comparison to a control group of the same anthroposphere were systematically investigated. Research methods: In a case-control study patients with sMCS were investigated in comparison to a not MCS affected control group of the same …
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Lineage-Specific Phenotypic Abnormalities in iPSC-Derived Smooth Muscle Cells from Type-I Loeys-Dietz Syndrome
… at the aortic root, where smooth muscle cells (SMCs) from two distinct embryonic origins – the lateral mesoderm (LM) and neural crest (NC) – are intermingled. SMCs are hypothesised to be the key cell type contributing to TAA development. However, only LM-SMCs showed abnormal functionalities in …
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Effects of heparinoids on bovine aortic smooth muscle cells
Smooth muscle cells (SMCs) comprise the bulk of the tunica media of all blood vessels. Upon injury to the overlying endothelial monolayer of blood vessels, SMCs proliferate into the lumen of the vessel and cause dangerous occlusions. The glycosaminoglycan (GAG) heparin has been shown to be …
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Charakterisierung des proinflammatorischen Phänotyps neointimaler glatter Gefäßmuskelzellen nach Gefäßverletzung
… denudation. In laminar flow assay neointimal rat SMCs supported a higher arrest of monocytes and "memory" T lymphocytes than medial SMCs. The enhanced arrest was dependent of both, P-Selektin and VLA-4, as demonstrated by pretreatment with blocking antibodies. The increase in monocyte arrest on …
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Smooth Muscle Cell Stress Response: Essential in Atherosclerotic Pathogenesis
… and prominent role of smooth muscle cells (SMCs) in atherosclerotic plaque formation. SMCs undergo complex phenotypic modulation characterized by de-differentiation of SMCs and heterogeneously increased expression of markers for macrophages, fibroblasts, chondrocytes, and mesenchymal stem …
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Effects of The Acta2 R258C Mutation On Vascular Smooth Muscle Cell Phenotype and Properties
… to injury. We characterized smooth muscle cells (SMCs) from bothmouse models under the hypothesis that mutant α-actin has a dominant negative effect, leading to impaired contractile filament formation/stability, improper focal adhesion maturation and increased proliferation.</p> <p>Explanted …
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Smooth Muscle Hyperplasia Due to Acta2/Myh11 Mutations: Identification of Novel Pathology and Pathways Leading to Aneurysms and Diverse Vascular Occlusive Diseases
… disease. To test this hypothesis, ACTA2 mutant SMCs and myofibroblasts were assessed and found to not form á-actin filaments whereas control cells did, suggesting a dominant negative effect of ACTA2 mutations on filament formation. A loss of á-actin filaments would be predicted to cause …
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Targeting Metabolic Alterations Associated With Smooth Muscle Α-Actin Pathogenic Variant Attenuates Moyamoya-Like Cerebrovascular Disease
… mouse model, 67% of the smooth muscle cells (SMCs) in the vasculature express the heterozygous <em>Acta2</em> R179C mutation. However, when SMCs are explanted from <em>Acta2</em><sup>SMC-R179C/+</sup> mouse aortas, the population is completely heterozygous for the mutation. Here, I show that …
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Tensile Properties of Single Vaginal Smooth Muscle Cells
… we tested single vaginal smooth muscle cells (SMCs) to quantify their elastic moduli. Cells were enzymatically isolated from vaginal walls of freshly sacrificed, virgin Long Evans rats and cultured using well-established methods. A custom-built experimental setup was used to perform tensile …
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Direct Reprogramming of Fibroblasts into Smooth Muscle Cells
… and differentiated into smooth muscle cells (SMCs) when seeded on a Collagen IV substrate and maintained in differentiation media (DM). The PiPS-SMCs expressed a panel of SMC markers such as SMA, SM22 and Calponin at mRNA and protein levels. Immunofluorescent staining of PiPS-SMCs showed …
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Developing an induced pluripotent stem cell model of pulmonary arterial hypertension to understand the contribution of BMPR2 mutations to disease-associated phenotypes in smooth muscle cells
… PAH-associated phenotypes in iPSC-derived SMCs. To achieve this, I used CRISPR-Cas9 gene editing to generate wild-type and BMPR2+/- iPSC lines with isogenic backgrounds which were subsequently differentiated into lineage-specific iPSC-SMCs that displayed a gene expression profile and …
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Molecular Mechanisms of Vascular Disease In Patients With Rare Variants In Myh11
… are predicted to disrupt contractile function. SMCs are the predominant cell type in the ascending aortic wall. Mutations in <em>MYH11</em>, encoding the smooth muscle specific myosin heavy chain, are a rare cause of inherited TAAD. However, rare but recurrent non-synonymous variants in …
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Polo-Like Kinase 1 and Smooth Muscle Cells in Coronary Artery Bypass Conduits and Coronary Arteries Following Angioplasty
… mitotic progression of smooth muscle cells (SMCs) from human IMA and SV in the development of IH leading to veingraft disease. We also show in vivo data in support of increased immunopositivity towards PLK1 and pPLK1 in SMCs, following percutaneous transluminal coronary angioplasty (PTCA) and …
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Characterization of Inducible SMC-specific Drosha Knockout Mice
Smooth muscle cells (SMCs) play an important role in the contraction of gastrointestinal (GI) smooth muscles, generating spontaneous action potentials and forming electrical and mechanical junctions coupling with interstitial cells. Recent studies have shown that microRNAs (miRNAs), a new class of …
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Development of Iron-Based Soft Magnetic Composites with Novel Coating Materials
Soft Magnetic Composites (SMCs) are an exciting class of material, with the potential to replace steel laminations as the magnetic core material used in electric motors. The main advantage of SMCs is their isotropic magnetic properties, allowing for radically different design concepts as compared …
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The Effects of Smooth Muscle Cells on Engineered Microvasculatures in Fibrin Hydrogels
… project is to determine how smooth muscle cells (SMCs) affect angiogenesis during microvascular development in fibrin hydrogels using 3-dimensional co-culture models of angiogenesis. These studies are meant to model angiogenic processes in the wall of a fibrin-based tissue engineered blood vessel …
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
SMAC mimetic compounds (SMCs) are small molecule antagonists of the Inhibitor of Apoptosis (IAP) family of proteins. Binding of SMCs to the IAPs results in the sensitization of cancer cells to apoptosis in the presence of death ligands, such as tumour necrosis factor alpha (TNFα). I hypothesize …
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Vergleichende Untersuchung zu Lebensgewohnheiten und Lebensumfeld von Patienten mit selbstberichteter Multipler Chemikaliensensitivität, Duftstoffallergien oder Polyposis nasi
… factors of persons with self-reported MCS (sMCS), FA or PN.Material and Methods: Dependence of variable distribution of a standardized questionnaire of living conditions and living factors was compared between the three patient groups using Pearson’s X²-test. In case of a significant value, …
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Runx2 and Vascular Calcification
… and CKD (medial calcification). Because SMCs can undergo lineage reprogramming toward osteoblastic and chondrocytic fates during vascular calcification, we propose to determine whether SMC-specific Runx2 expression is required for development of AMC and AIC. We developed a mouse with …
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Size Effects in Shape Memory Ceramics
Bulk shape memory ceramics (SMCs) are attractive for their high transformation temperatures and transformation stresses compared to shape memory metals but exhibit transformation-induced cracking due to mismatch stresses arising at the grain boundaries. Current strategies for mitigating cracking in …
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