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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"sFLT-1"”.
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Prenatal exposure to maternal obesity and SFLT-1 overexpression and cardiovascular function in the adult offspring
… determine the effect of prepregnancy obesity and sFlt1-induced preeclampsia on cardiovascular function in the offspring in a small animal model. A link between increased blood pressure and amplified vascular reactivity was revealed in offspring born to mothers fed high fat diet and with or without …
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Role of SFLT-1 in vascular regulation in pregnancy and its effect on fetal vascular programming
… scavenger receptor, soluble VEGFR-1, also called sFlt-1, is believed to play a role in the pathogenesis of preeclampsia. \r\nWe created a mouse model of preeclampsia induced by administration of adenovirus carrying sFlt-1. We have shown that pregnant mice that over-express the sFlt-1 are …
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Role of RNA Processing Factors in the Expression of Flt-1 and its Secreted Variant, sFlt-1
… the formation of new blood vessels. sFlt-1, a secreted form of the signal-transducing VEGF receptor Flt-1, can inhibit cellular responses to VEGF both in vitro and in vivo. sFlt-1 is generated by alternative pre-mRNA processing; removal of Flt-1 intron 13 by splicing produces the mRNA …
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Comparison of Revvity soluble fms-like tyrosine kinase-1 and Placental Growth Factor methods on the DELFIA Xpress with Roche methods on the cobas e411: in a patient cohort with suspected preeclampsia as defined by NICE
… biomarkers; soluble fms-like tyrosine kinase-1 (sFlt-1) and placental like growth factor (PlGF), are increasingly used to support the diagnosis of preeclampsia in routine clinical practice. There are an increasing number of methods available for the analysis of these markers but data showing the …
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Evaluating the Expression of Angiogenic Mediators in a Mouse Model of Tumor Metastasis
… as either a membrane bound or a secreted form (sFlt-1) that can inhibit angiogenic signaling. Previous studies have shown that variation in mRNA expression of VEGF and its receptors KDR, sFlt-1 and Flt-1 occurs in pathological angiogenesis, i.e. metastatic tumorigenesis. We hypothesize that the …
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Role of the Intron 13 Polypyrimidine Tract in Soluble Flt-1 Expression
… KDR and Flt-1. A secreted form of Flt-1 (sFlt-1), derived from alternatively-spliced RNA, can inhibit actions of VEGF in vivo. It has been suggested that alterations in sFlt-1 expression could significantly change the angiogenic VEGF activity. This project focuses on characterizing …
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Ο ρόλος της λιποπρωτεΐνης (α) και του λιπιδαιμικού profile επιτόκων στην προεκλαμψία
… επίπεδα του αντι-αγγειογενετικού παράγοντα sFlt-1 και μειωμένα επίπεδα του PlGF, οδηγώντας σε συστηματική ενδοθηλιακή δυσλειτουργία. Παράλληλα, αυξανόμενα δεδομένα υποδηλώνουν ότι το λιπιδαιμικό προφίλ της κύησης και ιδιαίτερα η λιποπρωτεΐνη (α) ενδέχεται να διαδραματίζουν σημαντικό ρόλο …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Vascular Fetal Programming in a Mouse Model of Preeclampsia
… 1, or soluble fms-like tyrosine kinase1 (sFlt-1). The soluble Flt-1 is generated by differential mRNA splicing of VEGF receptor 1. Soluble Flt-1 acts as a potent antagonist of VEGF and PlGF by preventing them from binding to their endothelial cell receptor, VEGFR-1 and VEGFR-2. Recently, …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Fetal Vascular Programming in a Mouse Model of Preeclampsia
… 1, or soluble fms-like tyrosine kinase1 (sFlt-1). The soluble Flt-1 is generated by differential mRNA splicing of VEGF receptor 1. Soluble Flt-1 acts as a potent antagonist of VEGF and PlGF by preventing them from binding to their endothelial cell receptor, VEGFR-1 and VEGFR-2. Recently, …
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Markers and mechanisms of pre-eclampsia in pregnancies complicated by diabetes
… factors, soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin (sEng) from placental trophoblasts into the maternal circulation promotes endothelial dysfunction associated with pre-eclampsia. The aim of this thesis was to investigate whether modified lipoproteins and/or elevated …
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Modeling of interactions between vascular endothelial growth factor family members and their receptors KDR and Flt-1
… endothelial cells. A secreted form of Flt-1 (sFlt1) retains high affinity for VEGF and can compete for VEGF binding, thereby inhibiting angiogenic responses. In this study, a computational model of this ligand-receptor binding system is used to quantitatively describe the activation of KDR …
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Ο ρόλος της Βιταμίνης D στην προεκλαμψία
… D στο μητρικό αίμα με τον αγγειογενετικό δείκτη sFlt-1/PlGF, στο πλαίσιο της ισχαιμικής νόσου του πλακούντα και των συνακόλουθων διαταραχών της μητρικής και εμβρυϊκής κυκλοφορίας, όπως η προεκλαμψία και η ενδομήτρια καθυστέρηση ανάπτυξης. Η μελέτη ήταν προοπτικού χαρακτήρα, διάρκειας δύο ετών, …
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Clinical utility of 3D power doppler ultrasound and maternal biomarkers in the prediction of pre-eclampsia in high-risk pregnancies
… Factor (PlGF), soluble Fms-like tyrosine kinase (sFLt-1) and soluble Endoglin (sEng)) measured in the first and second trimesters of pregnancy to predict pre-eclampsia in high-risk women.<br/><br/>To determine the added clinical utility and predictive value of these biophysical and biochemical …
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Estudio multidisciplinar de potenciales marcadores precoces de preeclampsia: estudio en muestras de sangre obtenidas en el primer trimestre de gestantes sanas y con preeclampsia
… si biomarcadores maternos clásicos (PlGF, sFlt-1, ?-hCG y PAPP-A) y novedosos (ADNlc y MPc), medidos durante el primer trimestre, permiten predecir el desarrollo posterior de preeclampsia (PE) y sus complicaciones graves. Metodología: Se realizó un estudio retrospectivo de casos y controles …
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OVEREXPRESSION OR REDUCED BIOAVAILABILITY OF VEGF DURING MOUSE POST-NATAL INTESTINAL DEVELOPMENT ALTERS THE PROLIFERATION OF INTESTINAL STEM CELL PROGENITOR CELLS
… the overexpression of soluble VEGF receptor (sFLT-1) within the gastrointestinal tract. After three weeks of VEGF overexpression, mutant mice displayed an increase in villus height and proliferation in the transit-amplifying zone with the decrease of crypts per measured length and …
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Nuevos marcadores en el diagnóstico y pronóstico de la preeclampsia precoz y tardía
… PlGF; forma soluble de la tirosina quinasa-1, sFlt-1 y cociente sFlt-1/PlGF) y de un marcador cardiovascular (fragmento amino-terminal del pro-péptido natriurético tipo B, NT-proBNP) en comparación con los marcadores clásicamente utilizados (transaminasas y ácido úrico) en el diagnóstico de la …
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Análisis de la circulación cerebral fetal mediante power doppler tridimensional en gestaciones complicadas con diabetes gestacional y su relación con el estado proinflamatorio materno
… Se encontraron diferencias en el ratio sFlt-1/PlGF entre los grupos (P =0,04). Se encuentra correlación negativa entre los niveles de PlGF y el IP medio de las arterias uterinas (r= -0,5, p=0,01) y corrleación positiva con el índice cerebropacentario-uterino (r=0,45, p=0,01). Se …
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The role of heparin and heparin-binding growth factors in pre-eclampsia
… localisation of HBGFs and receptors VEGFR-1, /(sflt-1), PLGFR-1, VEGFR-2 and FGF2R-1 in placenta were detected. The expression of VEGF, PLGF, FGF2, HGF, PDGF, CD105 was confined to villous trophoblast, endothelial cells except for MK, HB-EGF and PTN was specifically to villous trophoblast. The …
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A Peripartum Assessment of Nailfold Capillary Density in Women With Preeclampsia
… (ROS) and soluble fms-like tyrosine kinase one (sFlt-1), cause systemic endothelial dysfunction, ultimately leading to hypertension and accompanying symptoms of PE. While symptoms typically resolve after delivery, those with a history of PE are at an increased risk of developing cardiovascular …
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