Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"sAPPα"”.
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Observing the effects of acetylcholinesterase and brain-derived neurotrophic factor on the levels of soluble amyloid precusor protein α in lung cancer cell media
… levels of soluble amyloid precursor protein α (sAPPα) were higher in H1299 cell media compared to A549 cell media. With these previous findings, we hypothesize that the levels of sAPPα are regulated by AChE and mBDNF. When cells were treated with AChE, sAPPα levels were decreased while Aβ levels …
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SEX-DEPENDENT GUT MICROBIOME DIFFERENCES IN A TRANSGENIC MOUSE MODEL OF AUTISM
… of a relationship between the overexpression of sAPPα, the non-amyloidogenic cleavage product of Amyloid Precursor Peptide (APP), and the abnormal neurological development observed in individuals with Autism Spectrum Disorder (ASD). Changes in the diversity of the gut flora, and co-occurring …
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The Processing of Amyloid Precursor Protein in the Central Nervous System of Humans and Rhesus Macaques
… This results in the release of soluble APPα: sAPPα), which precludes the release of Aβ, thus making this pathway non-amyloidogenic.</p><p>Several studies have focused on measuring the products of APP cleavages in an effort to elucidate the pathophysiology of AD. These studies give a static …
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Apolipoprotein E4 and SirT1 Interaction in Alzheimer’s Disease
… α-site produces two neuroprotective peptides: sAPPα and αCTF. Recent data have shown significantly lower sAPPα levels in cerebrospinal fluid of AD patients who possess one or more ε4 allele. Recent research studies have focused attention on Sirtuins. SirT1 plays a role in synaptic plasticity, …
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Sodium dichloroacetate (DCA) impairs β-secretase-mediated proteolysis of the alzheimer's disease amyloid precursor protein (APP)
… of the protein producing soluble APPalpha (sAPPα) and a membrane-associated C-terminal fragment (C83) and precluding the formation of intact Aβ-peptides. In this study we show that, in human neuroblastoma SH-SY5Y cells, the mitochondrial modulator dichloroacetate (DCA) impairs the …
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The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on cell viability, ADAM10 maturation and the proteolysis of ADAM10 substrates in SH-SY5Y cells
… and liberating a neuroprotective fragment, sAPPα. This latter proteolytic event is catalysed by a disintegrin and metalloproteinase (ADAM) 10. Recent research has suggested that glucagon-like peptide-1 (GLP-1) analogues; Lixisenatide, Dulaglutide, Liraglutide, and Exenatide (Exendin-4), …
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The role of the E2 copper binding domain in the cell biology of the amyloid precursor protein
… the Aβ region generating soluble APP alpha (sAPPα). APP itself binds to copper at a number of sites, including a recently identified E2 copper binding domain (E2 CuBD) within the extracellular region of the protein. The current project aims were to investigate how copper binding within the …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… amyloid precursor protein alpha and beta (sAPPα/β), Aβ38, 40, 42, and ten other biomarkers validated as predictors of mild cognitive impairment and progression in previous studies. These include apolipoprotein C3, pre-albumin, α1-acid glycoprotein, α1-antitrypsin, PEDF, CC4, ICAM-1, RANTES, …
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APP Processing: A Biochemical Competition Influenced by Exercise-Induced Signalling Mediators
… However, there was an increase in the ratio of sAPPα to sAPPβ protein content (p=0.05) after 30 minutes of post-exercise serum treatment. Additionally, 30 minutes of post-exercise serum treatment increased ADAM10 (p=0.01) and BACE1 (p=0.02) activity. These novel findings suggest that …
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Μελέτη του ρόλου συστατικών των στύλων του φυτού Crocus sativus και άλλων ενδημικών ειδών Crocus σε νευροπροστατευτιούς μηχανισμούς με έμφαση στη νόσο του Alzheimer
… των αμυλοειδικών (sAPPβ) και μη-αμυλοειδικών (sAPPα) μορφών της ΑΡΡ, στο θρεπτικό μέσο καλλιέργειας των CHOAPP770 κυττάρων. Η trans-κροκίνη-4 αύξησε τα επίπεδα έκκρισης των sAPPβ, γεγονός που υποδηλώνει την πιθανή εμπλοκή των μονάδων σακχάρων στη διαδικασία της αμυλοειδογένεσης. Δεν …