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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"s1p"”.
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Investigation of S1P and S1P Signaling in Adipocytes and Adipocyte-Breast Cancer Cell Interaction
… Sphingosine-1-phosphate (S1P) is the final product of sphingolipid metabolism, affecting proliferation, apoptosis, inflammation, and angiogenesis. Common therapeutic strategies for targeting S1P in cancers showed little successful progress. In contrast, data have shown the …
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Relationship Between CB1 and S1P Receptors in the Central Nervous System
… cannabinoid (CB1) and sphingosine-1-phosphate (S1P) receptors in the CNS, but potential functional relationships between these lysolipid receptors have not been examined. Therefore, to investigate possible relationships between these two systems at the level of G-protein activation, …
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The role of N-cadherin and S1P/S1P1 in pancreas development
… to be important for dorsal pancreas formation. S1P acts on receptors (S1P1, S1P2, and S1P3) expressed in the pancreatic mesenchyme, inducing mesenchymal growth. Studies on the S1P1 receptor knockout showed a reduced size of the dorsal pancreatic bud due to decreased proliferation of Pdx1+ cells. …
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Is there an association between S1P signaling and the transcription factor Nrf2?
… conditions. Synthesized by sphingosine kinase, S1P regulates several cellular events through five sphingosine 1-phosphate receptors. S1P has been associated with poor prognosis in cancer, metastasis and chemotherapeutic resistance. Dysregulated Nrf2 and S1P are able to enhance chemotherapeutic …
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Identification of novel biomarkers for clinical prognosis in breast cancer
Sphingosine kinase/sphingosine 1-phosphate (SK/S1P) signalling interacts with major cellular pathways controlling cell proliferation, migration, survival, and resistance to chemotherapeutics. Moreover, extensive research has shown that the SK/S1P signalling is up-regulated in numerous human cancers …
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Role and Regulation of Sphingosine 1-Phosphate In Erythrocyte
<p>Sphingosine 1-phosphate (S1P) is a bioactive signaling sphingolipid produced in every mammalian cell. It plays a variety of important roles both in and outside of cells. S1P is highly enriched in mature erythrocytes because of the high enzymatic activity of the S1P-generating enzyme Sphingosine …
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Sphingosine-1-Phosphate and Fingolimod (FTY720) Regulate ICl,swell In HL-1 Cardiac Myocytes via Intracellular Binding And Mitochondrial ROS Production
… We previously suggested sphingosine-1-phosphate (S1P) activates volume-sensitive Cl- current (ICl,swell) by ROS-dependent signaling. S1P and its analog, FTY720 (fingolimod), primarily act via G-protein coupled receptors (S1PR; S1PR1-3 in heart), but several intracellular S1P ligands are known. We …
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INTRACELLULAR TARGETS OF SPHINGOSINE-1-PHOSPHATE
… lipid mediator sphingosine-1-phosphate (S1P) has emerged as a key regulator of a variety of important physiological functions, including cell growth, cell survival, cell motility, angiogenesis, lymphocyte trafficking, and mast cell function. S1P is formed by two different sphingosine …
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Structure-activity relationship studies and biological evaluation of selective sphingosine kinase inhibitors
Sphingosine 1-phosphate (S1P) has become a prevalent drug discovery target due to studies implicating it to several disease pathologies such as fibrosis, sickle cell disease, inflammation, diabetes, and cancer. S1P functions to induce cell proliferation and migration. S1P signaling occurs through …
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ROLE OF HEPATIC APOLIPOPROTEIN M AND ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN LIPID METABOLISM
… and transports sphingosine 1–phosphate (S1P). We found that liver–specific apoM transgenic mice had larger plasma HDLs enriched with apoM, cholesteryl ester, lecithin:cholesterol acyltransferase and S1P, but not enhanced macrophage reverse cholesterol transport compared to wild type …
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Developing Sphingosine-1-Phosphate (Spns2) Inhibitors for the Treatment of Multiple Sclerosis
… disease progression. Sphingsoine-1-phosphate (S1P) is a lipid that is important for the trafficking of lymphocytes into a person's central nervous system. This trafficking is largely due to the natural gradient of S1P which is high levels in blood but low in tissues. Lymphocytes will follow …
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Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries
Introduction: Sphingosine 1 phosphate (S1P) is a major constituent of high density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but the mechanisms involved remain unclear. Janus …
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Cell-Type Specific Translational Profiling in Huntington's Disease Mouse Models
… One novel pathway was sphingosine-1-phosphate (S1P) signaling. Because the S1P-receptor G-protein coupled receptor 6 (GPR6) is enriched in striatopallidal cells, we hypothesized that changes in this pathway might play a role in striatopallidal medium spiny neuron vulnerability. Using mass …
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Development of Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spns2 for the Treatment of Multiple Sclerosis
Sphingosine-1-phosphate (S1P) is an amino-alcohol signaling molecule produced from the intracellular phosphorylation of the lipid sphingosine. Despite possessing several identified intracellular targets, the predominant signaling functionality of S1P is derived from its activation of membrane-bound …
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The role of sphingosine-1-phosphate in the epithelial to mesenchymal transition in cancer cells
Sphingosine-1-Phosphate (S1P) is a bioactive lipid that has been shown to regulate hallmark cancer characteristics, one of which is Epithelial to Mesenchymal Transition (EMT). EMT is the mechanism by which an epithelial cell gains the motility to migrate throughout the body by shifting from a …
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Receptor-mediated calcium entry in retinal amacrine cells
… activate a class of g protein-coupled receptors (S1PRs) in other cell types. In the present study, we examine the signaling properties of S1P in retinal amacrine cells. S1P produced a noisy, inward cation current in amacrine cells that occurred through activation of S1P1R and S1P3R. The …
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Design, Synthesis, and Structure-Activity Relationship Investigation of Selective Sphingosine Kinase Inhibitors
… the formation of sphingosine-1-phosphate (S1P), which is an important signaling molecule that regulates multiple biological process including inflammatory responses. Elevated SphK1 activity as well as upregulated S1P levels is linked to various diseases such as cancer, fibrosis and sickle …
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The role of the arterial glycocalyx in sphingosine-1- phosphate induced cardioprotection in the isolated heart of the Wistar rat
… damaged during I/R. Sphingosine-1-phosphate (S1P) is a membrane phospholipid metabolite that has been shown to protect the heart against I/R. It has also been shown to regulate the synthesis of glycocalyx, but its effects on coronary endothelial glycocalyx damage and possible mechanism during …
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Rol de los esfingolípidos en los procesos activados por estrés oxidativo en neuronas y células gliales de retina
… mientras que la esfingosina-1-fosfato (S1P, por sphingosine-1-phosphate), que se sintetiza por fosforilación de esfingosina, tiene importantes funciones como promotor de la proliferación y supervivencia. Por lo tanto, la regulación del metabolismo de los esfingolípidos podría ser una …
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Improving Potency and Oral Bioavailability of Spinster Homolog 2 (Spns2) Inhibitor: A Structure-Activity Relationship Study
… response is the lipid sphingosine-1-phosphate (S1P). Interactions of S1P with its response-inducing receptors prompts the release of immune cells, lymphocytes in particular, from lymph tissue to migrate and participate in the invoked immune response. The pharmaceutical industry has produced five …
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