Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 197 for “"s Disease"”.
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A Comparison of the Frontal Variant of Alzheimer's Disease with Typical Alzheimer's Disease and Frontotemporal Dementia
A frontal variant of Alzheimer's Disease (FvAD) has been described in the literature in which prominent frontal lobe dysfunction accompanies typical temporal and parietal lobe dysfunction in the early stages of the illness. However, no study has investigated how executive deficits and …
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The role of mTOR signaling in Alzheimer s disease
The majority (>95%) of Alzheimer s disease (AD) cases are sporadic and of unknown causes. The single major risk factor for AD is aging and molecular changes that occur in the brain as a function of age may facilitate the development of AD. However, little is known as to how the aging process …
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Evolution of Surgery Risk in Crohn's Disease
While many individuals with Crohn’s disease require surgery for management, the risks of surgery are not well characterized in population-based studies. Advances in medical management may have influenced the risk of surgery over time. However, studies have not adequately evaluated the effect of …
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A retrospective analysis of nerve function impairment in Hansen's disease cases in the United States National Hansen's Disease Programs
… (NFI) in the upper extremity in the Hansen's disease (HD) (Leprosy) population being diagnosed and treated by the National Hansen's Disease Programs. A retrospective cohort of 197, mean age 47 was examined to determine if the amount of NFI, as defined by the World Health Organization (WHO) …
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Functional Connectivity of Entorhinal Cortex in Alzheimer's Disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by prominent memory impairment, executive dysfunction, language, construction, and visuospatial deficits. In AD, the accumulation of neurofibrillary tangles neuritic plaques, and other associated neuropathology, …
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Tower of California Performance Early in Parkinson's Disease
Cognitive impairment associated with Parkinson's disease (PD) is widely described in the literature. Executive dysfunction has been reported even when the patients are not experiencing dementia. A significant (24% - 50+%) number of PD patients display cognitive impairment from the onset of the …
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Frontal-lobe mediated word retrieval in Parkinson's disease
… when examining cognitive function in Parkinson's disease.
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Utility of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Battery Total Score in the Progression of Alzheimer's Disease
… to Establish a Registry for Alzheimer's Disease (CERAD) created a neuropsychological battery that is both brief and sensitive to dementia (Morris et al., 1989). Chandler et al. (2005) put forth a method of calculating a Total Score for the CERAD along with normative data. The objective of …
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Dementia in Parkinson s Disease: relationship between clinical and neurobiological aspects
Il deficit cognitivo è uno degli aspetti più comuni e importanti della malattia di Parkinson (PD), influisce notevolmente la qualità e l aspettativa di vita del paziente. Lo spettro delle disfunzioni cognitive nei PD è stato recentemente codificato in termini di Mild Cognitive Impairment …
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MODELLING GBA1-RELATED PARKINSON¿S DISEASE PATHOLOGY IN PATIENT-DERIVED MIDBRAIN ORGANOIDS
… key neuropathological hallmarks of Parkinson’s disease. Mutations in GBA1, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s disease and are the most frequent genetic risk factor for Parkinson’s disease. However, a defined link between mutations in GBA1 and …
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Parkinson's disease: An investigation of relevant marital and family factors
… of persons suffering from idiopathic Parkinson's disease (PD) ; (b) explore factors believed to be associated with caregiver burden; and (c) investigate factors believed to be correlated with the amount of assistance in activities of daily living required by the patient. These factors included …
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Investigating the mechanisms by which PINK1 protects against Parkinson's disease
… of PINK1 function, cause early onset Parkinson’s disease (PD). This thesis aimed to investigate the mechanisms by which PINK1 protects against PD, with a focus on PI3-kinase/Akt signalling. Akt signalling is central to cell survival, metabolism, protein and lipid homeostasis, and is impaired in …
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Changes in Brain Functional Connectivity Following Donepezil Treatment in Alzheimer's Disease
… (ROIs) in eleven patients with mild Alzheimer's disease (AD) following treatment with the cholinesterase inhibitor, donepezil. The ROIs were selected on the basis of their association with cholinergic neurotransmission, AD neuropathology, and neurocognitive deficits in AD. These ROIs included the …
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Familial Alzheimer's Disease Mutations in Presenilins Disrupt Endoplasmic Reticulum Calcium Leak
Alzheimer disease (AD) is the most common form of progressive dementia in adults over the age of 65 years. AD is a fatal brain disease and it currently affects about 27 million people worldwide. It is speculated that the number of people affected by AD will quadruple by 2050. The presence of …
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Towards a translational understanding of colonic bacteria in Crohn's disease pathology
Crohn’s disease (CD) is a chronic inflammatory condition of unknown aetiology, with the microbiota thought to be a major contributor to the disease. This thesis aimed to investigate the potential role of the gut microbiota in this context. The approaches taken were to examine CD associated …
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A renewed vision for Amyloid beta and tau in Alzheimer s disease pathophysiology
… pathogenetic mechanisms underlying Alzheimer s disease (AD), a neurodegenerative disorder affecting the elderly and characterized by memory loss, personality changes and cognitive dysfunction leading to dementia. I will discuss the main projects in which I participated aimed at understanding the …
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Regulation of Astrocyte Functions by a Parkinson's Disease Gene, DJ-1
INTRODUCTION . 1 A. Parkinson's disease (PD) 1 B. Genes associated with PD . 2 1. DJ-1 (PARK7) 2 2. Other genes . 3 C. Function of astrocytes in the normal brain . 6 D. Function of astrocytes in the injured brain . 7 1. Reactive astrocytes : intermediate filaments (Ifs) and morphological features . …
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Neuropathological significance of PLD1 in Alzheimer's disease and behavioral variant frontotemporal dementia
… disorders including Alzheimer’s disease (AD). Our lab established, for the first time, an elevated PLD1 expression in crude synaptosomes from AD post-mortem brains and further demonstrated the effect of amyloidogenic insults amyloid-β (Aβ) and tau in wildtype mice, implicating a …
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