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Showing 1 to 5 of 5 for “"rs7903146"”.
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Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
… associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. Clinical, animal and in vitro studies have revealed an association of the risk T-allele of rs7903146 with impaired β cell function including …
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An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome.
… rs8192678 (Gly482Ser) of the PPARGC1A gene, rs7903146 of Transcription Factor 7 Like 2 (TCF7L2) gene, rs9939609 of Fat mass and obesityassociated (FTO) gene and rs1801282 (Pro12Ala) of peroxisome proliferatoractivated receptor gamma (PPARG) gene with the metabolic syndrome and its components …
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The genetic background of gestational diabetes mellitus
… the transcription factor 7-like 2(TCF7L2) rs7903146, rs12255372 and rs7901695 SNPs, the 1858 C>T SNP of the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and we tested for the presence of islet cell autoantibodies against glutamic acid decarboxylase 65 (GAD65), …
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IDENTIFYING GENES THAT CONTRIBUTE TO TYPE 2 DIABETES SUSCEPTIBILITY IN CAUCASIAN AND AFRICAN AMERICANS
… on association results. Apart from TCF7L2 (rs7903146, Pa=1.59x10-6), we observed little evidence of association with T2DM in AAs. In fact, only rs9300039 in an intragenic region of chromosome 11p12 was associated with T2DM after admixture adjustment (Pd=0.029). The primary objective of this …
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Exploring the Grey Zone between Type 1 and Type 2 Diabetes
… T2D-associated genotypes of TCF7L2 CT/TT of rs7903146 were significantly more common in young GADA- than in GADA+ patients. No such difference was seen in middle-aged patients, in whom the frequency of the CT/TT genotypes of TCF7L2 was similarly increased in GADA- and GADA+ groups. We …