Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 73 for “"rotavirus"”.
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Recombinant BCG expressing rotavirus VP6 : construction and evaluation as an anti-rotavirus vaccine
Bibliography: leaves 188-207.
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Influence of Enteric Microbiota on Human Rotavirus and Human Norovirus Infection, and Rotavirus Immunity in Gnotobiotic Pigs
… effects of HGM on the immune response to oral rotavirus vaccination and rotaviral disease. We also used HGM transplanted Gn pigs to determine the effects of HGM on human norovirus infection. Despite commercially available vaccines, human rotavirus is a leading acute gastroenteritis in children, …
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Phase Separation Mediated Compartmentalisation of Rotavirus Replication
… replication and viral particle assembly in rotaviruses. Intrinsically disordered proteins are key drivers of LLPS. In rotaviruses, the disordered protein NSP5 binds the RNA chaperone NSP2, viral RNAs and other viral proteins to form replication factories known as viroplasms. Early in …
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Determinants of Rotavirus Polymerase Localization and Activity
Rotavirus (RV) is a viral pathogen that causes severe, watery diarrhea and vomiting in the young of humans and other animals. RV infections result in over 200,000 pediatric deaths around the world each year, especially in developing nations. Within the infected host cell, RV forms inclusion bodies, …
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Cell-Specific Inhibition of Interferon Production by Rotavirus
Rotavirus (RV) is a leading cause of diarrhoea in young children. In 2016, rotavirus-related death was estimated around 128,500, with 258,173,300 episodes of diarrhoea in children below 5 years. Although extra-intestinal rotavirus infection is limited, the spread of the virus can cause seizures and …
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Rotavirus interactions with silica and natural organic matter
Rotavirus is a leading cause of gastrointestinal infections worldwide resulting in severe diarrhea and dehydration among children (Parashar et al., 2006). Rotavirus “ubiquitous” occurrence in water systems raises fundamental questions regarding interactions with surfaces that may affect its fate …
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Determinants of Core Shell Dependent Rotavirus Polymerase Activity
Rotaviruses (RVs) are medically significant gastrointestinal pathogens and are a leading cause of childhood mortality in many countries. The RV RNA-dependent RNA polymerase, VP1, synthesizes RNA during viral replication only in the presence of another RV protein, VP2, which comprises the innermost …
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Modeling the impact of geographic targeting of rotavirus vaccination in India on rotavirus diarrhea mortality in children under 5 years of age
Background: Rotavirus causes around 329,000 diarrhea deaths annually around the world, almost a third of which are in India. The rotavirus vaccine is a relatively recent but important vaccine; an India-manufactured rotavirus vaccine was licensed for use in India in 2014. A total of 15 out of 31 …
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Arachidin 3 Modulation of Lipid Metabolism in Rotavirus Infections
<p>Rotavirus (RV) can cause severe and deadly gastroenteritis in young children, infants, and immunocompromised individuals. Previous studies have shown that arachidin 3 (A3) inhibits RV replication, and that RV replication is dependent on the presence of lipids. This study investigated the …
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Secretion of the rotavirus VP7 capsid glycoprotein from polarised epithelial cells
Despite the widespread implementation of rotavirus vaccination, rotaviruses remain a major cause of severe diarrhoeal disease in infants and young children worldwide. Rotavirus is a double-stranded RNA (dsRNA) non-enveloped virus that infects polarised epithelial cells lining the upper region of …
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Investigating the dynamic nature of biomolecular condensates that support rotavirus replication
Group A rotaviruses (RVAs) induce the formation of viral replication factories, termed viroplasms, where new viral particle packaging and genome replication occur. The formation of such factories is driven by liquid-liquid phase separation (LLPS) of an intrinsically disordered phosphoprotein NSP5, …
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Investigation of Novel Prophylactics Against Human Rotavirus Using Gnotobiotic Pig Models
Human rotavirus (HRV) is a major causative agent of acute gastroenteritis (AGE), which causes severe dehydrating diarrhea in children under the age of five and results in up to 215,000 deaths worldwide each year. There are two live oral attenuated vaccines licensed for use in the United States that …
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Nutritional parameters associated with enteric Escherichia coli and rotavirus in poults
… to investigate the effects of E. coli and rotavirus as causative agents in producing infectious stunting syndrome of poults. The syndrome, as it occurs commercially, was characterized in two experiments to produce decreased digestible dry matter and nitrogen as well as increased excreta …
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Porcine rotavirus adsorption to 24 salad vegetables and sanitization by free chlorine
… In this study, we determined the number of rotaviruses adsorbed on produce surfaces using group A porcine rotaviruses and 24 cultivars of leafy vegetables and tomato fruits. We also characterized the physicochemical properties of each produce’s outermost surface layer, known as the …
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In Vitro and in Vivo Modulation of Rotavirus Infection by Soy Isoflavones
Rotavirus infections are the most common cause of diarrhea in infants worldwide. Although two vaccines have been recently developed and approved, their access to developing countries, where rotavirus incidence is high, may be limited. Therefore, the investigation of other cost effective strategies …
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Modeling fate and transport of Cryptosporidium parvum and rotavirus in overland flow
… in documented United States history. Similarly, rotavirus is the leading cause of death among children around the world. Each year more than two million children are hospitalized due to rotavirus infection and more than 500,000 children die from diarrheal disease caused by rotavirus. Past studies …
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Identification and characterization of an enterocyte receptor for group A porcine rotavirus
Rotaviruses are the most common agents of viral diarrhea in the young of many species, including piglets. A virus-host cell binding assay was developed and used to investigate specific binding between Group A porcine rotavirus and MA-104 cells or porcine enterocytes. A variety of glycoconjugates …
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The Role of Humoral Immunity in The Resolution of Rotavirus Infection in Mice
The immune response to rotaviruses has been studied extensively in several animal species. However, the importance of a humoral immune response in the resolution of active rotavirus infection has not been investigated directly. Most animals became resistant to rotavirus-induced diarrhea after a …
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Inactivation kinetics and mechanisms of rotavirus: the roles of sunlight, temperature, and sensitizers
U of I Only Restriction Lifted for Item 50581 on 2016-09-22T20:59:25Z.
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Expression Of Cholera Toxin B Subunit-rotavirus Nsp4 Enterotoxin Fusion Protein In Transgenic Chloroplasts
Rotavirus, the major cause of life-threatening infantile gastroenteritis, is a member of the Reoviridae family and is considered to be the single most important cause of virus-based severe diarrheal illness in infants and young children particularly 6 months to 2 years of age in industrialized and …
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