Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"romidepsin"”.
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Romidepsin is a Potential Therapeutic to Treat Metastatic Osteosarcoma
… In initial drug screens, our lab identified romidepsin, a histone deacetylase inhibitor, as a potent inhibitor of viability of highly metastatic osteosarcoma sarcospheres that was non-toxic to normal cells. Romidepsin was additive-to-synergistic with standardof- care chemotherapy and …
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Harnessing DNA nanoarchitecture to overcome immunoevasion in cancer
… signaling pathways. The chemical conjugation of romidepsin, a histone deacetylase inhibitor, to G3YSD-encoding dendrons resulted in more than a 2-fold increase in MHC I expression compared to unconjugated G3YSD sequences and free romidepsin, indicating that the spatial arrangement and …
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MEMORY TH17 CELLS IN THE LUNG DURING SECONDARY BACTERIAL PNEUMONIA FOLLOWING INFLUENZA A VIRUS INFECTION
… approved histone deacetylase inhibitor (HDACi), Romidepsin (RMD), acts as a novel adjuvant to augment antigen-specific Th17 responses in the lung and improve immunization-induced protection against co-infection. Animals immunized with vaccine adjuvanted with RMD display increased survival, body …
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Development Of Elisa-Based Hdac Activity Assay For Identification Of Isoform Selective Hdac Inhibitors
… in various stages of clinical trials. SAHA and Romidepsin are FDA-approved drugs for the treatment of cutaneous T-cell lymphoma. Human HDAC proteins have high sequence similarity and hence many known inhibitors non-specifically interact with all or most of the eleven HDAC isoforms, leading to …