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Showing 1 to 9 of 9 for “"roller compaction"”.
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The use of roller compaction as granulation method for hydrophilic extended release matrix tablets
This work evaluated the use of roller compaction as granulation method for hydroxypropyl methylcellulose (HPMC) based hydrophilic extended release matrix tablets. Roller compaction is a dry granulation method where powder material is fed through a hopper between two counter-rotating rolls and …
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The Effect of Crystalline and Amorphous Lactose on Mechanical Properties of Roller Compaction Ribbons and Tablets
… The mixture of forms exhibit unique material compaction properties that facilitate performance within formulations. Lactose is infrequently used in large concentrations for dry granulation processes because alpha-lactose monohydrate exhibits relatively poor binding properties and consolidates …
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A STUDY ON PARTICLE SURFACE ROUGHNESS AND ITS IMPACT ON TABLET AND INHALER TECHNOLOGY
… available for bond formation. The effects of roller compaction on materials of different deformation properties were examined. Roller compaction of elastic material was found to improve tableting properties, while brittle materials were insensitive to roller compaction and plastic materials …
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Development and Bioavailability/Bioequivalence of a Fixed-Dose Combination Antiretroviral Reconstitutable Suspension Intended for Pediatrics
… patients. The granules were developed via roller compaction process to improve granule flow characteristics, minimize segregation of the multi-component active pharmaceutical ingredients, and avoid introducing moisture into the formulation and thereby improve the stability of the product. …
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Effect of Compression Force on Agglomeration of Micronized Active Pharmaceutical Ingredients: Techniques to Prevent API Agglomeration During Compression
… like physical mixing, hexane slurry method, roller compaction and spray drying. The particles were characterized for change in crystal structure, polymorphism and surface morphology by X-ray diffraction, thermal studies and microscopy studies.</p> <p>Micronized furosemide and griseofulvin …
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Near-Infrared (NIR) Spectroscopy-based Pharmaceutical Process Analytical Technology (PAT) Systems: Risk and Performance
… indices of powder blending, tableting, and roller compaction. The International Conference on Harmonization (ICH) Q9 guidance provides strategies for implementing quality risk management with respect to product development. This dissertation focuses on extending these concepts for assessing …
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Novel Application of Twin Screw Extruder on Production of Diverse Formulations
… dry granulation technologies, slugging and roller compaction, have some limitations: single batch operation, low manufacturing throughput, high amounts of fines and dust, inferior tensile strength of final tablet and loud operation. The previously unreported study of applying twin screw …
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Characterisation of Tablets and Roller-Compacted Ribbons with Terahertz Time-Domain Pulsed Imaging
… pharmaceutical process of dry granulation using roller-compaction (DG/RC) is effectively a non-batch based procedure orientated to deliver a continuous stream of material free of a pre-defined batch-size with reduced plant equipment/scale-up R&D resources and an enhanced work-throughput, …
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Development of Co-processed Plasticized Cellulose Acetate for Sustained Release Matrix Tablets
… and inert excipient. The physical, flow and compaction properties of the co-processed excipients were evaluated. All the co-processed excipients prepared in this study all showed good flow characteristic. The spray dried process produced high porous particles with large surface area. These …