Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"roflumilast"”.
-
Treatment During Abstinence from Methamphetamine in a Rat Model of Methamphetamine Use Disorder
… model in the rat was used in which roflumilast, a phosphodiesterase 4 inhibitor, was administered during the abstinence period before a relapse test. The overarching hypothesis was that roflumilast inhibited inflammation associated with METH self-administration abstinence to reduce …
-
Regulation of cAMP-Dependent Gene Expression in Airway Epithelial Cells: A Transcriptional and Pharmacodynamic Analysis
… genes could help prevent exacerbations. Roflumilast is a phosphodiesterase (PDE) 4 inhibitor approved by the United States Food and Drug Administration as an ‘add-on’ therapy for patients with severe, bronchitic COPD with a history of frequent exacerbations. The second objective was to …
-
Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells
… with better potency namely trequinsin, roflumilast N-oxide and vidofludimus, were identified. Of these compounds, vidofludimus which is known to be an inhibitor of the dihydroorotate dehydrogenase (DHODH) enzyme, proved to be the most potent (IC50~1.4μM) SOCE inhibitor among all the …