Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 134 for “"rodent models"”.
-
Orbitofrontal Cortex and Social Processing in Rodent Models
Social processing is the reception, interpretation, and reciprocation of social information and is critical for mental health. The neural structures, circuits, and substrates regulating these complex mechanisms are not well understood. Social processing in the form of social safety learning, as …
-
Low Dose Dosimetry and Radiation Response in Rodent Models
… sophisticated small animal lung tumorigenesis models to investigate the carcinogenic risks of low dose radiation.
-
Rate alterable traumatic brain injury device for rodent models
… of increasing rates of pressure rise time on the rodent brain. A series of behavioral studies are conducted including neurological severity tests immediately after the injury followed by rotarod, ladder rung walk, metric and spatial information, and Morris water maze tasks between 1 to 15 days …
-
Cardiac mitochondrial respiration in two rodent models of obesity
… males. We examined our hypothesis employing two rodent models i.e. a) a rat model of diet-induced obesity and b) a transgenic (leptin receptor deficient) mouse model of obesity-induced type II diabetes. For the diabetic mouse model, we determined cardiac mitochondrial respiratory function in an …
-
Dietary interventions for reduction of prostate carcinogenesis in rodent models
Prostate cancer (PCa) is the second leading cause of cancer and cancer related deaths in U.S. men; thus, identifying strategies to reduce PCa incidence could have a significant impact on public health. Epidemiological studies have supported the hypotheses that dietary intake of soy foods or tomato …
-
Neurogenesis Dependent Learning And Implications For Episodic Memory In Rodent Models.
… memory in rats, and relates it to previous models and its potential application for human episodic memory. In chapter 3, we present research comparing adult neurogenesis between spatial and non-spatial hippocampal dependent tasks. The results presented in chapter 3 suggest that neurogenesis …
-
Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent Models
… mechanisms underlying pattern separation, using rodent models and behavioural tasks that assess the use of representations for similar stimuli. Pattern separation is a theoretical mechanism involving the transformation of inputs into output representations that are less correlated to each other. …
-
Effects of diet and loss of ovarian hormone production on adiposity, inflammation, cecal integrity, and gut microbial communities of rodent models
Menopause is an age-related loss of ovarian hormone production that has been linked with obesity-associated metabolic dysfunction, increased visceral adiposity, and inflammation, although the mechanisms remain unclear. Obesity has been strongly linked with profound shifts in the gastrointestinal …
-
Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models
… copy number) alterations in C57/BL6 rodent models. These changes preceded overt disease onset, as classified by clinically utilized indices, which included the homeostatic model assessment for insulin resistance (HOMA-IR), the homeostatic model assessment for β-cell dysfunction (HOMA- …
-
Regulation of Energy Balance by Dietary Protein
… markers and thermogenesis were determined in rodent models of diet-induced obesity. In addition, the tissue distribution of the transcripts for proglucagon, glucose-dependent insulinotropic peptide, peptide YY and their cognate receptors in feline peripheral tissues and the effects of the …
-
Passive Acoustic Mapping of Microbubbles in Focused Ultrasound Induced Brain Therapies for Preclinical Studies
… for clinical uses, preclinical studies in rodent models with precise anatomical targeting and monitoring must be conducted. This thesis discusses the development of a high-resolution transmit-receive FUS array with a novel broadband receiver designed to conduct BBBM treatment for …
-
Atividade antiulcerogênica de Alcaloides Pirrolizidínicos obtidos a partir do Extrato Etanólico de Senecio brasiliensis: perspectivas de uma nova terapêutica preventiva e curativa das úlceras gástricas e duodenais
… antiulcerogenic activity of the PAs on Standard rodent models. Furthermore this study also evaluated the probable pharmacological mechanism(s) of the PAs. The results showed the antiulcerogenic activity on gastric and duodenal induced ulcerogenic lesions. The pharmacological mechanisms showed …
-
Finite element modeling of temperature elevation due to NIR exposure in neural tissue
… neural tissue when illuminated with NIR light. Rodent models are frequently used to study laser-tissue interactions. As a part of ongoing research project in the neural interface laboratory, direct measurements of temperature in the rat brain cortex as a response to a pulsed sequence of NIR …
-
ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST
… system display antidepressant properties in rodent models of depression they may represent a novel mechanism for treatment of depressive symptoms in humans.</p>
-
Meta-Analysis of Rodent Behavior in Various Brain Injury and Disease Models
… was to identify patterns and profiles present in rodent behavioral assay data to inform methodology of future animal research. Domains of spatial learning, motor function, activity, and emotionality were examined. This study first identified how rodent performance on commonly used behavioral and …
-
Aberrant hippocampal neurogenesis contributes to learning and memory deficits in a mouse model of repetitive mild traumatic brain injury
… such as brain injury. Previous findings in rodent models have characterized the effect of moderate traumatic brain injury (TBI) on neurogenesis and found learning and memory shortfalls correlated with limited neurogenic capacity. While there are no substantial changes after one mild TBI, …
-
Aerobic exercise training as a mitigator of nonalcoholic fatty liver disease related fibrosis
… is difficult to study in humans, therefore rodent models often are used to better understand factors that cause NASH. Additionally, it is unclear if aerobic exercise training can be used to treat the fibrosis that is associated with NASH. In the present study, lean and hyperphagic,obese rats …
-
A COMPARISON OF 2D IMAGE ANALYSIS AND DESIGN-BASED STEREOLOGY FOR EVALUATING MORPHOLOGICAL AND ANATOMICAL CHANGES IN THE DOPAMINERGIC SYSTEM OF THE RODENT MIDBRAIN
… Methods. Brain tissue samples of three different rodent models were analyzed; chronic MPTP/probenecid PD (MPD) mouse model, alcohol preferring (AP) rat model, and the enriched environment (EE) rat model. 2D analyses and design-based stereology were used to quantify neuronal number, neuronal volume …
-
Design, implementation and validation of an exoskeletal robot for locomotion studies in rodents
… basic research frequently involves rodent models of neurological injury, which motivates robotic devices that can interact with rats or mice. Currently, available apparatus for locomotion studies of rodents is built upon treadmills, which simplify the design and implementation but …
Page 1 of 7