Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"rodent model"”.
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Optimization of overhead enclosure monitoring software in a rodent model of osteoarthritis
… on both naturally occurring and induced animal models for its study. The Dunkin Hartley guinea pig spontaneously develops degenerative joint disease as early as 3 months of age and represents a well-characterized animal model of primary OA with pathological progression similar to humans. In …
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The effect of isometric tongue exercise in a novel rodent model of dysphagia
… This project utilizes our previously established rodent model that develops dysphagia as a consequence of only tongue dysfunction. This model was created by injecting a toxin into the genioglossus muscle of the tongue for selective death of motor neurons in the hypoglossal nucleus, a brainstem …
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A novel developmental rodent model to investigate the neural basis of episodic memory
… Object Place Context (OPC) task was used as a model of episodic memory and used alongside the Novel Object Recognition (NOR), Object Context (OC) and Object Place (OP) tasks, all of which were tested in two days. <br/>It was discovered that all ages tested could perform basic object recognition …
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Anatomical and Functional Characterization of the Ventral Hippocampus in a Rodent Model of Schizophrenia Neuropathology
… the disease, the appropriate choice of an animal model is essential. The "MAM E17" model of hippocampal pathology shows anatomical, neurophysiological, and behavioral changes relevant to schizophrenia. Because of these wide-ranging disease-relevant changes, we aimed to relate anatomical to …
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Habit Formation in a Rodent Model of Alcoholism: Genetic Susceptibility, Alcohol-Specific Effects, and Pharmacological Manipulation
Habit formation is a well-characterized process involving a shift from response-outcome as the leading driving force underlying action to a stimulus-response mechanistic process. It is hypothesized that a transition from goal-directed behavior to habitual behavior is driven by a transition of the …
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Nicotine Sensitization in a Rodent Model of Schizophrenia: A Comparison of Adolescents, Adults, and Neurotrophic Factors.
… effects of nicotine on locomotor activity in a rodent model of psychosis were analyzed. This model is based on neonatal quinpriole treatment (a dopamine D2/D3 agonist) which causes increased D2 receptor sensitivity, a phenomenon known as D2 priming that is common in schizophrenia. D2-primed …
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Establishing a Rodent Model of Postoperative Pain: Investigating Potential Sex Differences and Changes in Gene Expression
… females. To address this, we established a rat model of postoperative pain and assessed potential sex differences in mechanical hypersensitivity. To optimize data collection, adult male and female Sprague Dawley rats received handling or tickling prior to testing. USVs were recorded, and tickled …
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Glial Changes and Role of Connexin43 in a Laser-induced Rodent Model of Retrobulbar Optic europathy
Purpose: To establish a novel model of rodent optic nerve damage in order to investigate glial changes occurring in retrobulbar portion of the optic nerve after the injury and to facilitate development of neuroprotective agents. Methods: Rats (200-250g) were first anaesthetised via intraperitoneal …
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Investigating the neurobiology regulating cognitive effort allocation using a rodent model of cost/benefit decision making
… allocation. These experiments utilize an animal model of decision making known as the rodent Cognitive Effort Task (rCET), in which subjects decide whether to exert more attention in pursuit of larger rewards, or to obtain smaller reward for comparatively less attentional demand. In experiment 1, …
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The Effects of Nicotine Administration on Behavior and Markers of Brain Plasticity in a Rodent Model of Psychosis
… behavior and brain plasticity in an adolescent rodent model of schizophrenia with the goal of identifying targets for smoking cessation. Methods: Rats were neonatally treated with quinpirole (a D2/D3 agonist) or saline and sensitized to 0.3, 0.5, or 0.7 mg/kg (free base) nicotine or saline, …
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The Role of Membrane Lipid Composition on Skeletal Muscle Damage in the Rodent Model of Duchenne Muscular Dystrophy
Duchenne muscular dystrophy is a X-linked muscle disease, which leads to alterations in membrane phospholipid fatty acid (FA) composition and skeletal muscle damage. Increased membrane saturated FA in muscular dystrophy may suggest its association with increased susceptibility (as being the cause …
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Identification of dopamine neuron progenitors in the embryonic midbrain and stem cell cultures - Studies on the role of neuronal subtype and differentiation state for cell replacemen in a rodent model of Parkinson's disease
Parkinson’s Disease (PD) is a neurodegenerative disorder where the dopamine producing neurons in the ventral mesencephalon (VM) progressively die and result in symptoms such as resting tremors, muscle rigidity, slowness and difficulties in initiating movements.Currently there is no cure for PD and …
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Gonadotrophins and cytokines in ovarian epithelial cancer / John Alexander Latimer
… the effects of ovarian hyperstimulation using a rodent model. The study provides also information about cytokine expression and production in benign and malignant ovarian tissue, both in humans and animals.
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Evidence for the role of delta-6-desaturase in the development of cardiometabolic disease
… whether inhibition of D6D in vivo in established models of heart failure and type 2 diabetes (T2D) reverses changes in fatty acid membrane composition associated with disease pathogenesis and attenuates associated cardiometabolic insults, and 2) Determine whether over-expression of fads2, the gene …
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Design and Validation of Medical Devices for Photothermally Augmented Treatments
*1-Dimensional Advective-Diffusion Model in Porous Media Infusion of therapeutic agents into tissue is makes use of two mass transport modes: advective transport, and molecular diffusion. Bulk infusion into a 0.6% wt agarose phantom was modeled as an infinite, homogenous, and isotropic porous …
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Individual differences in cocaine's locomotor activating effects predicts reward-directed behavior
… dependence. Addiction-like behaviors have been modeled in rodents as well with similar individual variability in the development of addiction-like behaviors. One potential mechanism that could differentiate addiction-vulnerable from addiction-resistant individuals is sensitivity to reward-paired …
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Crotalus Snake Venom Preconditioning to Prevent Surgical Brain Injury
… has been shown to minimize injury in many animal models. Given the elective nature of most neurosurgical procedures, the surgical brain injury (SBI) rodent model provides an ideal platform for preconditioning. Our work shows that preconditioning with Crotalus rattlesnake venom, known for its …
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Chronic Olanzapine Treatment Eliminates Cognitive Deficits Produced by Neonatal Quinpirole Treatment.
… performance and neurochemical function in a rodent model of schizophrenia. Animals were neonatally treated with quinpirole, a dopamine D<sub>2</sub> receptor agonist, or saline. Quinpirole treatment produces an increase of dopamine D<sub>2</sub> receptor sensitivity that extends into …
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