Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"rodent brain"”.
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The Role of Nogo-A in Memory and Neuronal Plasticity in the Aged Rodent Brain
… antibody treated rats. In the hippocampus, a brain area important for spatial memory, we found a decrease in dendritic complexity on the same side as the stroke when compared to normal aged rats. However, anti-Nogo-A immunotherapy did not prevent this decrease in dendritic complexity in the …
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Characterization of Cu-rich aggregates in neurogenic niches of the rodent brain by X-ray fluorescence microscopy
<p>Copper is an essential element in the brain playing several critical roles ranging from neurotransmitter synthesis to ATP production. As Cu is typically present in micromolar concentrations and has a spatially capricious distribution in the brain, determining concentrations has historically been …
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The Role of Temperature in the Preparation and Viability of Rodent Brain Slices, and Propensity to Evoke Spreading Depolarization
… propagates across the higher grey matter of the brain and is the primary contributor to acute neuronal injury. Within minutes of the brain being deprived of oxygen and glucose (OGD), Na+/K+ pumps on neuronal membranes fail and membrane potential is lost, resulting in SD. Experimentally, SD can be …
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Detection and Imaging of Neurotransmitters in Rodent Brain Tissue Using FMP-10 and ZnO Nanoparticle Matrices with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
… (ZnO NP), to image neurotransmitters in rodent brain tissue. FMP-10 facilitates on-tissue chemical derivatization to detect 17 neurochemicals, notably dopamine, γ-aminobutyric acid (GABA), serotonin, and norepinephrine. ZnO NP detects 9 neurochemicals, including glutamate and glutamine, …
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Cortical recording with conducting polymer electrodes
… of time is essential to understanding how the brain reorganizes during motor learning. Conventional chronic recording microelectrodes are made from metal or silicon. However, the large stiffness mismatch between the electrodes and brain tissue causes shear-induced inflammation, limiting …
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Surgical system for image-based stereotaxy in the rat
… apparatus for target determination in the brain of animals. Until now, the only stereotactic devices for directing problems and electrodes in animal brains for neuroscience are based on dental and ear canal fixation and on skull based features which are at best crudely related to brain …
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Developing digital and analog spiking neural Networks for interacting with biological Tissues in the Case Study of temporal lobe Epilepsy
… capable of recording local field potentials from brain tissues, particularly, rodent brain slices. This real-time interaction with brain tissues through the MEA system presented opportunities to validate the functionality of the SNN in a physiological context. The implementation of the SNN began …
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Noninvasive optical inhibition with a red-shifted microbial rhodopsin
… the causal assessment of their contributions to brain functions, but a limit to the utility of optogenetic modulation is the quantity of neural tissue that can be successfully addressed from a given optical source. Previous optogenetic inhibitors are driven by blue, green, or yellow wavelengths, …
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Effect of hypoxia on spontaneous neural activity in the cortex of neonate mouse pups
… effects on the normal functioning of the brain in mammals. Acute or chronic hypoxic insults occur in the brain depending on the duration of hypoxic exposure. Hypoxia is known to occur in the human womb and exerts adverse effects on the developing fetus. Most of the ongoing research on …
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Effect of hypoxia on spontaneous neural activity in the cortex of neonate mouse pups
… effects on the normal functioning of the brain in mammals. Acute or chronic hypoxic insults occur in the brain depending on the duration of hypoxic exposure. Hypoxia is known to occur in the human womb and exerts adverse effects on the developing fetus. Most of the ongoing research on …
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Thermotherapeutic enhancement of infusate distribution during convection enhanced delivery in the brain using fiber-optic microneedle devices
… multiforme (GBM) is the most common malignant brain tumor in adults and has a median survival of 13.4 months. Convection enhanced delivery (CED) has shown promise for the treatment of GBM by allowing intratumoral delivery of therapeutics, bypassing the blood brain barrier. A fiberoptic …
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The medial prefrontal cortex and the dorsomedial striatum are necessary for working memory in rats: role of NMDA receptors
… cortical and striatal areas in the human and rodent brain, I used rats to elucidate the contrbutions of N-methyl-D-aspartate (NMDA) receptors in medial prefrontal cortex (mPFC) and dorsomedial striatum (dmSTR) using two working memory tasks. The trial unique non-match to location (TUNL) task …
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Investigating circuit and spatial heterogeneity of human brain tumors with patient-derived organoid models
… glioblastoma (GBM), are aggressive adult primary brain cancers with dismal prognosis. Both malignant cell heterogeneity and the influence of myriad cell types present in the tumor microenvironment, such as neurons, contribute to glioma progression. This dissertation represents a multi-pronged …
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Rate alterable traumatic brain injury device for rodent models
Traumatic Brain Injury (TBI) is a physical impact to the head resulting in functional deficits in memory and motor systems. TBI is a prevalent problem occurring in 1.7 million people annually in the United States (Faul et al. 2010). TBIs can differ greatly in terms of the biomechanics of the impact …
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Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target.
… cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. As the name implies, the mPT is defined by a sudden increase in permeability of the inner mitochondrial membrane, …
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Characterisation of a Novel GABA Signalling System in the Human Cerebral Vasculature
… inhibitory neurotransmitter in the mammalian brain, underlying diverse functions from the maintenance of consciousness and the formation of memories to the regulation of the processes underlying brain development and circadian rhythms. While GABAergic regulation in neuronal tissues has been …
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Visualization and manipulation of microRNA in neural cells
… to be highly abundant in certain regions of the brain. It has also been shown that alterations in levels of specific miRNAs have implications in various neurodegenerative disorders. However, the role of individual miRNA remains poorly understood. There are various methods that are used to …
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Mechanism and Function of TrkB.T1 Astrocyte Expression
… born during the early postnatal period in the rodent brain and mature alongside neurons, demonstrating remarkable morphological structural complexity, and attaining maturity in the second postnatal month. We have shown that astrocyte morphogenesis is regulated in part by brain-derived …
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CELL REPLACEMENT THERAPY FOR PARKINSON’S DISEASE: The importance of neuronal subtype, cell source and connectivity for functional recovery
… This involves transplantation of developing midbrain cells from aborted fetuses, (the part that form mesDA neurons), into the striatum of a PD patient. Clinical trials have demonstrated that CRT can provide long-lasting, significant clinical benefit. Although some patients do not respond as …
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Protein factors and 5' flanking sequences involved in the expression of the mouse myelin basic protein gene.
… purpose, nuclear extracts were prepared from rodent brain or established glial cell lines e.g. C6 glioma cells. Extracts from tissues and cell lines, which do not express myelin basic protein e.g., HeLa cells served as a control. Nuclei were isolated by Dounce homogenisation of cultured cells …
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