Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"rod photoreceptor"”.
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cis-Regulation in the Mammalian Rod Photoreceptor
… dual regulation of a single binding site can produce diverse gene expression patterns. I conclude that simple <italic>cis</italic>-regulatory elements can produce complex expression outputs due to interactions between transcriptional activators and detailed quantitative models will be necessary …
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Functional groups in rhodopsin and the rod photoreceptor membrane
Contains fulltext : mmubn000001_188726705.pdf (Publisher’s version ) (Open Access)
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Rod Photoreceptor Regeneration in a Zebrafish Model with Retinitis Pigmentosa
… degenerative diseases is progressive loss of photoreceptors until one is completely blind. Unlike mammalian models, Zebrafish have the ability to naturally regenerate their neurons after injury or disease is detected. We have generated a zebrafish model with the most common autosomal dominant …
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Regulation of rod photoreceptor phosphodiesterase (PDE6) by the glutamic acid -rich protein 2 (GARP2)
<p>Rod photoreceptor phosphodiesterase (PDE6), the central enzyme of visual transduction in vertebrate photoreceptors, associates with the disk membranes of the rod outer segment (ROS) of the photoreceptor cell. This association insures the high efficiency of activation by the G-protein, …
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Mechanism of activation of photoreceptor phosphodiesterase by transducin and by low molecular weight proteins
<p>Rod photoreceptor phosphodiesterase (PDE) is the central enzyme of visual transduction. PDE is a heterodimer (Palphabeta) with two associated inhibitory gamma subunits, and is bound to the disk membrane by isoprenyl groups. Each catalytic subunit contains a catalytic site and a high-affinity …
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Using a seed-network to query multiple large-scale gene expression datasets from the developing retina in order to identify and prioritize experimental targets
… the differentiation of retinal progenitors into photoreceptors in the developing retina is important not only due to its therapeutic applications in treating retinal degeneration but also because the developing retina provides an excellent model for studying CNS development. Although several …
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Functional analysis of A 5' untranslated variant in rhodopsin : implications for the retinitis pigmentosa phenotype
… degenerative diseases that predominantly affect rod photoreceptor cells. Symptoms include night blindness and gradual peripheral vision loss, which progresses to a complete loss of vision. Clinical, phenotypic and genetic heterogeneity are frequently observed in RP. Mutations in Rhodopsin (RHO) …
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The Isolation of Human Rod and Cone Photoreceptor Activity combining Electroretinography and Silent Substitution Techniques
… be used to independently assess the function of rod and cone photoreceptors within the human retina. The work in this thesis sought to investigate an alternative method of recording the ERG, using the silent substitution paradigm (Estevez and Spekreijse 1982). The aims are separated into two …
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rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration
The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) …
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Ablation of Retbindin, the Riboflavin Binding Protein, Exacerbates Retinal Degenerative Phenotypes in Mouse Models of Human Retinal Diseases
… binding protein, expressed only by the rod photoreceptor cells. Riboflavin is the precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which are essential co-factors for enzymes involved in wide-range of metabolic processes. Since flavins are directly linked to …
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Signaling Mechanisms That Control Gap Junctional Coupling Between Retinal Neurons
… an obligatory component of the high-sensitivity rod photoreceptor pathway. A fundamental requirement of the retina is to adapt to broadly varying inputs in order to maintain a dynamic range of signaling output. Modulation of the strength of electrical coupling between networks of retinal neurons, …
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Characterization of Retinal Defects in Engrailed-2 Knockout (En2-/-) Mice, a Model for Autism Spectrum Disorders (ASD)
… a reliable animal model for investigating the neurodevelopmental basis of autism spectrum disorders, as they display some ASD-related anatomical deficits, including cerebellar hypoplasia (Joyner A L, et al., 1991), reduced Purkinje neurons numbers (Kuemerle B, et al., 1997), altered anatomy of the …
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Molecular Dissection of Multifunctional Proteins in Rod Outer Segments
<p>Rod photoreceptors are specialized neurons responsible for capturing photons and translating visual information into electrical signals. Visual signal transduction in rods is confined to the unique outer segment organelle, a modified primary cilium consisting of a stack of hundreds of flattened …