Global ETD Search
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Showing 1 to 2 of 2 for “"rnf115"”.
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Ubiquitylation regulates vesicle trafficking and innate immune responses on the phagosome of inflammatory macrophages
… that phagosomal recruitment of the E3 ligase RNF115 is enhanced upon IFN-γ stimulation and RNF115 is responsible for most of the increase of K63 polyubiquitylation of phagosomal proteins. Knock-down of RNF115 promotes phagosome maturation and induces an increased pro-inflammatory response to …
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The Bca2 And Ampk Paradigm: Unraveling The Cancer Connection
… Breast Cancer Associated Gene 2 (BCA2/Rabring7/RNF115), a novel RING-finger ubiquitin E3 ligase, is overexpressed in >50% of breast tumors. Herein, I hypothesized that BCA2 is an endogenous inhibitor of AMPK activation in breast cancer cells and that BCA2 inhibition would therefore increase the …