Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"rifapentine"”.
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Determination of Rifapentine and 25-O-desacetyl Rifapentine from 100 µl human breastmilk by LC-MS/MS using protein precipitation and solid phase extraction
… on the transfer of the second-line anti-TB drug, rifapentine and its metabolite, into breastmilk. The subsequent implications to the breastfed infant, as well as consequences of long-term exposure to potentially sub-therapeutic drug levels with regards to the development of drug resistant bacteria …
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Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics and dissolution kinetics in vitro
The efficacy of rifapentine, an oral antibiotic used in the treatment of tuberculosis, is reduced due to its degradation at gastric pH and low solubility at intestinal pH. We aimed to improve delivery properties in vitro by incorporating rifapentine into pH-responsive amorphous solid dispersions …
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Optimization of 1st-line antituberculosis dosing regimens using a population pharmacokinetic approach: food effects, drug combinations and pharmacological effects
… Food effect (breakfast) was evaluated on rifapentine pharmacokinetic data in 35 healthy male volunteers. Effect of co-administered intermittent rifapentine on the pharmacokinetics of moxifloxacin was evaluated in 28 patients with pulmonary tuberculosis, who participated in a multicenter …
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Variability in the pharmacokinetics of rifapentine in South African tuberculosis patients : a classical and population approach
… at our disposal. Treatment regimens based on rifapentine, with its less demanding schedule, lack of autoinduction and increased absorption following food intake could make it an excellent candidate to anchor an intermittent chemotherapy regimen. The studies thus far on patients receiving …