Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"rickettsiae"”.
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The role of dendritic cells in rickettsial infection; initation of early immunity to spotted fever group Rickettsiae
… that Th1 responses are essential for immunity to rickettsiae; however, they do not address mechanisms important in initiating early immunity, particularly those involving dendritic cells. Dendritic cells are instrumental in initiation and control of a strong Th1 response towards invading …
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Autophagy and Inflammation During Rickettsial Infection
Rickettsiae are obligately intracellular bacteria that replicate in the cytoplasm of host cells. In my dissertation, I have studied the induction of autophagy by rickettsiae as well as the role of autophagy in the pathogenesis of rickettsioses in vitro and in vivo. I found that autophagy is induced …
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The Activation of the Inflammasome during Rickettsial Infection
Rickettsiae are Gram-negative, obligately intracellular bacteria that infect endothelial cells and macrophages. The molecular mechanisms involved in interaction of rickettsiae with macrophages, however, remain poorly understood. In this dissertation, I have investigated the canonical and …
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Mechanisms of increased microvascular permeability during acute Rickettsiosis
… Mountain spotted fever and epidemic typhus. Rickettsiae primarily target the microvascular endothelium leading to increased microvascular permeability, the mechanisms of which are completely unknown. We sought to determine the impact of host responses to infection on increasing microvascular …
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Characterization of rickettsial infection dynamics within Dermacentor variabilis and Amblyomma maculatum
… Transovarial and transtadial transmission of rickettsiae was most successful for R. amblyommii and R. parkeri in both, A. maculatum and D. variabilis eggs, larvae, and nymphs. Maintenance of rickettsiae in both tick species via transstadial transmission was diminished from unfed larvae to …
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Characterization of the Bacterial Microbiome of Exotic Tick Species Collected from Migratory Birds
… in <em>Ixodes</em> genera. Spotted fever group rickettsiae were detected in samples of <em>Amblyomma sabanerae</em> and <em>Amblyomma maculatum</em>. These findings provide an insight into the bacterial communities residing within the tick species parasitizing migratory birds.</p>
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Determining the Prevalence and Distribution of Tick-Borne Pathogens in Southeastern Virginia and Exploring the Transmission Dynamics of Rickettsia Parkeri in Amblyomma Maculatum
… its vector, Amblyomma maculatum. Although some rickettsiae are transovarially transmitted in ticks, little is known about the frequency and efficiency of this transmission route, and nothing is known regarding the transmission strategy of R. parkeri in A. maculatum. By understanding the dynamics …
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Identification of protective rickettsial antigens for vaccine development
… immunity between typhus and spotted fever group rickettsiae are attributed to the induction of antigen-specific T cells, particularly CD8+ T cells. Defining specific T-cell antigens and correlates of protective cellular immunity are critical steps towards vaccine development for Rickettsia. …
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The Internal Anatomy and Histology of Adult <em>Antricola mexicanus</em> Hoffman (Acari: Argasidae)
… tube appears to have no digestive function. No rickettsiae were visible in the malpighian tubules. The paired coxal organs consist of a tubular, alveolar structure, a sacculus, and a duct leading to the external opening between coxae I and II. No cuticular structure supports the lumen of the …