Global ETD Search
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Showing 1 to 3 of 3 for “"ribotoxin"”.
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Probing substrate specificity of RNA repair protein Pnkp/Hen1 from Anabaena variabilis
… a RNA repair protein—Pnkp/Hen1, which can repair ribotoxin cleaved tRNA in vitro and can add a methyl group at the cleaved site to prevent further cleavage, this study investigated the RNA secondary structure that this protein complex recognizes and repairs. First, three different truncated …
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Biochemical and structural studies of RNA damage and repair in bacteria
… own survival and growth. Many organisms utilize ribotoxins to respond to cellular stress or to kill competing organisms. Ribotoxins are site-specific endonucleases which typically target RNA molecules that are necessary for translation mainly, tRNAs and rRNAs which can result in their loss of …
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Discovery and characterization of novel RNA repair systems
… Pnkp/Hen1 complex has also been shown to repair ribotoxin-cleaved RNAs in vitro, but it was distinguished from T4 systems by performing 3’-terminal 2’-O-methylation during RNA repair, which prevents the repaired RNA from repeated cleavage at the same site. Bacterial Pnkp and Hen1 appear pair-wise …