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Showing 1 to 20 of 71 for “"ribosome biogenesis"”.
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… (16S, 23S, and 5S rRNAs) that form the ribosome are produced as a single transcript from an operon with minimal spacing between genes. In the B. burgdorferi genome, however, a single 16S rRNA gene is encoded more than 3 kb from the bicistronic 23S-5S rRNA operons. The 23S-5S operons are …
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… (16S, 23S, and 5S rRNAs) that form the ribosome are produced as a single transcript from an operon with minimal spacing between genes. In the B. burgdorferi genome, however, a single 16S rRNA gene is encoded more than 3 kb from the bicistronic 23S-5S rRNA operons. The 23S-5S operons are …
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Structural Studies of the Nucleolar Stages of Ribosome Biogenesis in Yeast
<p>The ribosome is the RNA-protein machine responsible for the essential task of translating mRNA into proteins. Ribosomes are heterodimers made up of a small subunit (SSU, 40S) and a large subunit (LSU, 60S). At the interface of these subunits, the mRNA is decoded by the small subunit and peptide …
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Dynamic Regulation of Ribosome Biogenesis and Its Role in Early Brain Development
… M. (2023a). The homeostatic regulation of ribosome biogenesis. Semin Cell Dev Biol 136, 13-26. [2] Ni, C., and Buszczak, M. (2023b). Ribosome biogenesis and function in development and disease. Development 150.
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Making Ribosomes: Biochemical and Structural Studies of Early Ribosome Biogenesis in Yeast
<p>The ribosome is a complex macromolecule responsible for the synthesis of all proteins in the cell. In yeast, it is made of four ribosomal RNAs and 79 proteins, asymmetrically divided in a small and large subunit. In a growing yeast cell, more than 2000 ribosomes are assembled every minute. The …
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A Non-Canonical Role for a Small Nucleolar RNA in Ribosome Biogenesis and Cellular Senescence
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Chemical Biology, Biochemical and Structural Studies of MDN1, an AAA Protein Required for Ribosome Biogenesis
<p>Cellular proteins are synthesized by ribosomes, which are ~3 MDa macromolecular complexes comprised of four ribosomal RNAs and ~80 ribosomal proteins in yeast. The biogenesis of such complicated ribonucleoprotein complexes is a highly regulated, multistep process requiring a plethora of more …
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The nucleolar protein NOC1 is essential for ribosome biogenesis, and its reduction activates a novel MYC-p53 axis mediating nucleolar stress
Ribosome biogenesis is a complex cellular process that relies on the coordinated action of numerous nucleolar proteins and RNAs; a crucial step in this mechanism is represented by rRNA processing and maturation. Defects in this process result in a condition known as nucleolar stress, a field of …
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Investigations into Why Human (but not mouse) KU70/80 is Essential Reveal a Role for Human KU70/80 in Ribosome Biogenesis
<p>The requirement of Ku70/80 for ribosome biogenesis in higher primates explains otherwise perplexing essential nature of this double-strand break (DSB) repair factor. We have ruled out telomere protection or DSB repair as the essential function ofKu70/80. Instead, unbiased genome-wide analyses …
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Elucidation of the Functional Architecture of the Early Pre-Ribosomal Processing Machinery in Yeast
<p>Ribosomes carry out one of the most fundamental functions of life - the translation of genetic information into functional proteins. The pivotal role of the ribosome in the cell is reflected in its immensely complicated and energy-consuming assembly pathway. The maturation of a eukaryotic …
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Characterization of Yeast 18S rRNA Dimethyl Transferase, Dim1p
Eukaryotic ribosome biogenesis, a dynamic and coordinated multistep process which requires more than 150 trans-acting factors, has been intensely studied in the yeast Saccharomyces cerevisiae. This evolutionarily conserved process involves numerous cleavages of pre-rRNA, modification of …
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Investigating WDR12 as a Therapeutic Target in Breast Cancer
… mining through genetic screens suggests that the ribosome biogenesis protein WDR12 is essential for breast cancer cell proliferation. In this study, we characterize the effects of WDR12 knockdown in a panel of breast cancer cells. We show that WDR12 knockdown induces ribosomal RNA (rRNA) …
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The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation with Arginine-Rich Nucleolar Proteins through Weak, Multivalent Electrostatic Interactions
… membrane-less organelles that are the sites for ribosome biogenesis and serve as sensors of cellular stress. Weak, multivalent protein-protein interactions and interactions between disordered, low complexity domains (LCDs) and rRNA have been shown to promote liquid-liquid phase separation (LLPS) …
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Dissecting SBDS function in Arabidopsis thaliana
Ribosome biogenesis has been extensively studied across various organisms, yet its complex mechanisms in plants remain underexplored. The SBDS protein, a highly conserved factor across eukaryotes, is essential for ribosome maturation and function. Interestingly, the Arabidopsis thaliana SBDS …
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GCN2 eIF2 Kinase Promotes Prostate Cancer by Maintaining Amino Acid Homeostasis
… in PCa cells, ultimately resulting in reduced ribosome biogenesis leading to the activation of a p53-dependent cell cycle checkpoint, termed the Impaired Ribosome Biogenesis Checkpoint (IRBC). Interestingly, induction of p53 promotes survival of PCa following GCN2 inhibition by halting cell …
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Systematic C-degron activity profiling implicates conditional regulation of the CTLH E3 ligase complex in ribosome maturation.
… gene AAMP plays an essential role in ribosome biogenesis: like its orthologue in yeast, Sqt1, AAMP exhibits chaperone activity towards the ribosomal protein uL16 to enable ribosomal maturation. Altogether, these data define a novel C-degron pathway through which the Muskelin substrate …
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"fine-tuning" of ribosomal structure and functions by pseudouridylation and rna-protein interactions
… interactions are another method to regulate ribosome biogenesis and activity. An ambient dissociation constant between the ribosomal RNA and ribosomal protein is required for the optimal ribosome biogenesis and activity (77nM for the E. coli cognate pair and 198 nM for the P. aeruginosa …
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The KsgA methyltransferase: Characterization of a universally conserved protein involved in robosome biogenesis
… that are intimately involved in ribosome biogenesis. Ribosome biogenesis is a complicated process, involving numerous cleavage, base modification and assembly steps. All ribosomes share the same general architecture, with small and large subunits made up of roughly similar rRNA …
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The post-translational methylation of arginine in the glycine arginine rich region of CHO nucleoin
Nucleolin is a nucleolar protein important for ribosome biogenesis. Nucleolin contains a conserved glycine arginine rich (GAR) domain near its carboxy terminus. GAR domains are defined by repeating tri-peptide, (arginine -glycine-glycine (RGG)) motifs. The arginine in the RGG motif is …
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