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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"ribosomal proteins"”.
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Isolation and Analysis of Single Ribosomal Proteins From Escherichia Coli
Made available in DSpace on 2014-12-09T22:04:18Z (GMT). No. of bitstreams: 1 6812117.pdf: 2855623 bytes, checksum: 6f1f9e048bb45951d11270a9fd0d3223 (MD5) Previous issue date: 1968
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Re-thinking the role of ribosomal proteins in the Mdm2-p53 axis
… One type of stress that can activate p53 is ribosomal stress, also called nucleolar stress. Ribosomal stress occurs when mishaps occur in ribosomal biogenesis, and various ribosomal proteins (RPs) have been shown to signal to Mdm2 and activate p53. This thesis presents two studies in the …
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A cancer screen in zebrafish identifies many ribosomal proteins as haploinsufficient tumor suppressors
… identified in the screen were ones in which a ribosomal protein (rp) gene was mutated. In total, 17 of 28 rp heterozygous lines were found to be predisposed to rare tumors, especially zebrafish malignant peripheral nerve sheath tumors (zMPNST). Though the precise molecular mechanism of …
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Some properties and function of ribosomal proteins from the seeds of Pinus lambertiana
Functional roles of ribosomal proteins (r-proteins) on the structural properties of ribosomes from Pinus lambertiana were studied. For this purpose, r-proteins in the ribosome were dansylated with dansyl chloride (l-dimethylaminonaphthalene-5-sulfonyl chloride) dispersed on celite (DNS-Cl-celite); …
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Modification of Ribosomal Proteins and the Topography of the 30s-Ribosome of Escherichia Coli
Made available in DSpace on 2014-12-11T18:16:52Z (GMT). No. of bitstreams: 1 7317329.pdf: 4725884 bytes, checksum: dd36536cad5ea76a8cfa71cfd8b0726f (MD5) Previous issue date: 1972
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Mass Spectrometric Analysis of Cytoplasmic Ribosomal Proteins in Drug Resistant and Drug Susceptible Human Cell Lines
… in MCF-7 breast cancer cells. Differences in ribosomal protein composition between drug susceptible and drug resistant cell lines were examined. Ribosomes were isolated from mitoxantrone susceptible and mitoxantrone resistant MCF-7 cells. The acid extracted ribosomal proteins were subjected to …
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Characterization of the effects of decreased expression of ribosomal proteins on cell transformation and cell cycle regulation
Thesis (Sc. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1996.
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Ribosomal Proteins RPLP1 and RPLP2 are Host Factors Critically Required for Flavivirus Infectivity by Promoting Efficient Viral Translation Elongation.
… including dengue virus (DENV). We identified two ribosomal proteins, RPLP1 and RPLP2 (RPLP1/2), that are crucial host factors required for translation of flaviviruses and efficient flavivirus infection of human cell lines and Aedes aegypti mosquitoes, which are natural vectors for these viruses. …
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An Investigation into the Effects of Alterations in Ribosomal Proteins S4 and S5 on Translational Accuracy, Ribosomal RNA Processing, and Ribosome Assembly
… expression and is carried out by the ribosome. Ribosomal proteins S4 and S5 are critical for the decoding and the assembly processes on the ribosome. The interaction between residues in the S4-S5 interface region is crucial for the large scale conformational changes occurring on the ribosome …
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The origin and evolution of the ribosome
… the structural elements of the ribosome, namely ribosomal RNA (rRNA) and ribosomal proteins (r-proteins) provided a deep and the most comprehensive insight possible yet into the origins and evolution of the ribosome. Using phylogenetic methods that reconstruct the evolutionary history of complex …
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Molecular visualization and localization of ribosomal subunits interaction in cells
… decay (NMD) and, more directly, by reports that ribosomal proteins are found associated with nascent transcripts on Drosophila polytene chromosome and that amino acids are incorporated at transcription sites. My project aimed to investigate further the question of whether there are functional …
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eL15 and eL22 proteins and their functional environments during ribosome assembly in Saccharomyces cerevisiae
… contained in mRNAs (messenger RNAs) to generate proteins. Similarly, the process of ribosome biogenesis represents a critical pathway for all cells. Ribosomes are comprised of two different subunits, one large and one small, also named 60S and 40S, respectively, in eukaryotes, among them …
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Resistance to protein synthesis inhibitors in Coprinus cinereus
… possible to Identify the particular cytoplasmic ribosomal subunit which conferred cycloheximide-resistance. Analysis of cytoplasmic ribosomal proteins by two-dimensional gel electrophoresis did not reveaú. any difference between the small subunit proteins of CY 8 and CY 8.2. There were a …
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Isolation And Characterization Of Human Ribosomal Protein Complementary-dnas
… In Escherichia coli the isolation and cloning of ribosomal RNA genes and ribosomal protein genes was a prerequisite to detailed investigations of expression of these genes. Research into ribosome biosynthesis in eukaryotes has lagged behind in part because of the lack of data on the structure of …
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Studies on a 50S Ribosomal Precursor Particle as a Substrate for <em>erm </em>E Methyltransferase Enzyme in <em>Staphylococcus aureus </em>.
… inhibits not only mRNA translation but also 50S ribosomal subunit assembly in bacterial cells. An important mechanism of erythromycin resistance is the methylation of 23S rRNA by <em>erm</em> methyl transferase enzymes. We are interested in investigating the true substrate for methylation because …
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Computational analysis of eukaryotic metatranscriptomes from diverse marine environments
… phytoplankton genome. Transcripts a�liated with ribosomal proteins and associated with translation dominated in all but the Equatorial Paci�c metatranscriptome sample. Hierarchical clustering of the metatranscriptome samples by taxa produced two groups: the diatom dominated and the alveolate …
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Functions of the eukaryote-specific ribosomal protein Asc1 /RACK1 in gene-specific translational activity
… single molecular entity, it is composed of both ribosomal RNAs and dozens of proteins. However, the individual contributions of most ribosomal components to translational regulation are unknown. In Chapter 1, I will review the current state of knowledge related to the functions of ribosomal …
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INVESTIGATING THE ROLE OF SPECIALIZED RIBOSOME DURING ERYTHROPOIESIS
Eukaryotic ribosomes are made up of ~80 ribosomal proteins (RPs) and 4 ribosomal RNAs (rRNAs), and are traditionally thought to be invariant in all cells. Recent studies have found that ribosomes can be heterogeneous in different cell types, and can regulate translation of specific subsets of …
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