Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"ribosomal biogenesis"”.
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The role of non-genetic variability in Acute Myeloid Leukaemia
… levels, including from genes involved in ribosomal biogenesis and translation (Domingues et al., 2020). No recurrent mutations in the KAT2A gene have been described in AML, and it is unclear if and how it participates in pre-leukaemia-to-AML progression. In this thesis, I studied Kat2a …
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Re-thinking the role of ribosomal proteins in the Mdm2-p53 axis
… One type of stress that can activate p53 is ribosomal stress, also called nucleolar stress. Ribosomal stress occurs when mishaps occur in ribosomal biogenesis, and various ribosomal proteins (RPs) have been shown to signal to Mdm2 and activate p53. This thesis presents two studies in the …
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Notchless Interacts with Multiple Signaling Pathways during Mouse Peri-Implantation Development
… NOTCH signaling, Nle1 is crucial for ribosome biogenesis. These seemingly contradictory data led me to hypothesize that mutation of Nle1 causes a lethal trauma to the embryo that disrupts multiple signaling pathways during peri-implantation development. I present data that: 1. Refute the …
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ZFAS1: a long non-coding RNA with novel implications for ribosome function
… to be localised with polysomes. Treatment with ribosomal elongation inhibitors and strategies to induce growth arrest did not change the abundance of ZFAS1 transcripts, suggesting that it does not regulate protein elongation. Induction of cell growth by serum starvation followed by refeeding …
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Investigations into the role of RNA modification in the function of the c-Myc IRES
… in the nucleolus, consistent with its role in ribosomal RNA modification and, ribosomal biogenesis. Fibrillarin adds a methyl group to the 2' position of the ribose sugar of an RNA molecule. This modification can affect RNA stability, function and interactions with proteins and small molecules. …
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Protein factors involved in the biogenesis of the mitochondrial ribosome
… of the protein components assisted by numerous biogenesis factors. The post-transcriptional modifications of the mt-rRNAs include base methylations, 2’-O-ribose methylations and pseudouridylation. However, the exact function of these modifications is unknown. Many mitoribosome biogenesis factors …
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Proteomics and dynamics of the human nucleolus
… established to be the site where the majority of ribosomal RNAs (5.8S, 18S and 28S) are transcribed, processed and assembled with ribosomal proteins to form ribosomal subunits. The sole role of ribosome biogenesis, however, cannot explain the specific nucleolar localisations of tumour suppressors, …