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Showing 1 to 20 of 653 for “"ribosomal"”.
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Mechanistic interrogations of ribosomal and non-ribosomal natural product enzymes
… cases are those falling under the class of ribosomally synthesized and post-translationally modified peptides (RiPPs), with a particular emphasis on the thiopeptide subclass of RiPPs. Additionally, characterization of an off-loading enzyme involved in hybrid polyketide/non-ribosomal peptide …
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Assembly of the 30S ribosomal subunit: positioning of ribosomal protein S13 in the S7 assembly branch
<p>Studies of Escherichia coli 30S ribosomal subunit assembly have revealed a hierarchical and cooperative association of ribosomal proteins with 16S ribosomal RNA; these results have been used to compile an in vitro 30S subunit assembly map. In single protein addition and omission studies, …
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Ribosomal Synthesis of N-methylated peptides
Natural peptide products isolated from various organisms often contain N-methylated backbones. Such a modification of backbone of the peptide changes its conformational rigidity. This modification improves the biological properties of the peptide, such as improved target affinity, proteolytic …
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Ribosomal Rna Precursors in Bacillus Subtilis
Made available in DSpace on 2014-12-09T22:04:17Z (GMT). No. of bitstreams: 1 6808104.pdf: 2498472 bytes, checksum: 5f7a1e2c144e81c1daf2cc700b14236e (MD5) Previous issue date: 1967
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Mechanism and regulation of ribosomal RNA transcription
… polymerase I (pol I) is the transcription of the ribosomal RNA (rRNA) genes. This transcription can account for up to 60% of the total cellular RNA that is being transcribed in an actively dividing cell. Due to the large amounts of energy this transcription requires, it is of utmost importance for …
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Transcriptional Regulatory Mechanisms of Ribosomal Protein Genes
Ribosomal protein genes are crucial for ribosome biogenesis. The ribosome itself is responsible for protein synthesis and hence cellular growth and development. Intertwining network of proteins in conjugation with cellular environment such as nutrition and growth factors collectively regulate …
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From ribosomal rotation to autism and cancer
… Here, we present evidence that the essential ribosomal protein L10 regulates this process in yeast ribosomes through a flexible loop located within 13 Å of the peptidyltransferase center. While deletion of the entire loop is lethal, viable mutants in this region were found to promote …
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Structural Analysis of the 50S Ribosomal Stalk
… Fortsatz gehört zu einer Erweiterung der 50S ribosomalen Untereinheit und besteht aus mehreren Kopien des Proteins L12, die über L10 an die ribosomale RNA geknüpft sind. Viele Hinweise sprechen dafür, dass L12 für die Bindung von Translationsfaktoren sowie der Stimulation ihrer …
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Relationships Among Precursor and Mature Ribosomal-Rna's
Made available in DSpace on 2014-12-11T18:16:51Z (GMT). No. of bitstreams: 1 7310058.pdf: 2882415 bytes, checksum: a73879088b596c69e513bbcdfce5e3ec (MD5) Previous issue date: 1972
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Silencing and recombination in yeast ribosomal DNA
A bioinformatic and laboratory investigation into S. cerevisiae's system for the maintenance and homogenization of rDNA. Eliminating mutations and heterogeneity in rDNA repeats is necessary evolutionarily, but harmful to individual organisms--and has been linked to aging-related pathology. We …
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Minor form of human 5.8s ribosomal RNA
Part One: The Minor Form of Human 5.8S rRNA An elongated form of 5.8S rRNA has been found in a wide range of eukaryotes from yeast to rodents. This minor form of 5.8S rRNA is about six nucleotides longer than the major form and composes from 10% to 30% of the total 5.8S rRNA found in yeast and …
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Messenger RNA Destabilization by -1 Programmed Ribosomal Frameshifting
… previous studies have identified programmed -1 ribosomal frameshifting (-1 PRF) signals in eukaryotic genomic sequences, and suggested a role in mRNA stability. This work improves and extends the computational methods used to search for potential -1 PRF signals. It continues to examine four …
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Evolutionary Measurements Using Ribosomal Rna Sequence Comparisons (Phylogeny)
Comparisons of complete 16S ribosomal RNA sequences have been used to confirm and refine the phylogeny of bacteria. Two bacterial 16S rRNAs have been analysed in this study.
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Procaryotic Phylogeny by Ribosomal Ribonucleic Acid Sequence Homology
Made available in DSpace on 2014-12-14T07:14:43Z (GMT). No. of bitstreams: 1 7624212.pdf: 3240225 bytes, checksum: ba20d63fd4626761196f98e3563e3434 (MD5) Previous issue date: 1976
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An Investigation into the Effects of Alterations in Ribosomal Proteins S4 and S5 on Translational Accuracy, Ribosomal RNA Processing, and Ribosome Assembly
… expression and is carried out by the ribosome. Ribosomal proteins S4 and S5 are critical for the decoding and the assembly processes on the ribosome. The interaction between residues in the S4-S5 interface region is crucial for the large scale conformational changes occurring on the ribosome …
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Isolation And Characterization Of Human Ribosomal Protein Complementary-dnas
… In Escherichia coli the isolation and cloning of ribosomal RNA genes and ribosomal protein genes was a prerequisite to detailed investigations of expression of these genes. Research into ribosome biosynthesis in eukaryotes has lagged behind in part because of the lack of data on the structure of …
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Studies on the Mode of Origin of Ribosomal Rna
Made available in DSpace on 2014-12-09T22:04:08Z (GMT). No. of bitstreams: 1 6406182.pdf: 3910009 bytes, checksum: c7adafdf64e2c48142193a2c7ea2eef4 (MD5) Previous issue date: 1963
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Alleviating ribosomal stalls: functional characterization of conserved Drg GTPases
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Models for the formation of 5.8S ribosomal RNA dimer
Ribosomal 5.85 RNA is a component of the large (605) ribosomal subunit in eucaryotes. Studies of 5.85 rRNA in solution have shown that under certain conditions, including standard isolation procedures, the molecule complexes with itself to form dimers and higher multimers. Two models have been …
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The L30e ribosomal protein from S. cerevisiae binds to its transcript RNA more strongly than to its primary target helix 58 of ribosomal RNA
<p>In <em>S. cerevisiae</em>, ribosomal protein L30e, in addition to being an integral part of the ribosome, autoregulates its levels of expression by: 1) binding to its transcript, inhibiting splicing; and 2) to its messenger RNA, inhibiting translation. This work explores ribosomal protein L30e …
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