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Showing 1 to 20 of 28 for “"ribonucleic acids"”.
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Isolation and analysis of ribonucleic acids
Ribonucleic acids are concentrated in certain parts of the cell. Separation of these parts usually precedes isolation of the ribonucleic acids they contain. This separation is accomplished by a process of cell fractionation (Mathias, 1966).
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Fluorescent Modifications of Transfer Ribonucleic Acids
Modifications of transfer ribonucleic acids (tRNA's) have been accomplished by chemical and enzymatic methods. The chemical modification has involved the reaction of methylmalondialdehyde (MMDA) with E. coli tRNA('Phe) with the hope of extending the use of substituted malondialdehydes and …
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Encoded synthesis and evolution of clinically approved 2'-modified ribonucleic acids
Xeno-nucleic acids (XNAs) are unnatural nucleic acids with altered sugar, phosphodiester backbone, or nucleobase components. 2'-modified nucleic acid chemistries, such as 2'-O-methyl-RNA (2'OMe-RNA) and 2'-O-2-methoxyethyl-RNA (MOE-RNA), have shown promise in clinical applications due to their …
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Structural Characterization of the Transfer Ribonucleic Acids From Halobacterium Volcanii and Other Archaebacteria
The archaebacteria have been defined primarily on the basis of their ribosomal RNAs, as a primary kingdom, distinct from the eubacteria ('prokaryotes') and the eucaryotes. To help in evaluating the molecular affinities, we characterize here the transfer RNAs (tRNAs) in two ways. First, we describe …
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A New Method to Characterize the Translation Initiation Sites of Messenger Ribonucleic Acids
Incomplete mercuration of mRNAs followed by incomplete and controlled {('125)I}I('+) displacement of the mercury from the intermediate 5-mercuripyrimidine derivatives of the Hg-mRNAs generates {('125)I}mRNAs containing high and approximately equal specific activity ('125)I-label in both …
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Quantitation of in Situ Hybridization of Ribosomal Ribonucleic Acids to Human Diploid Cells
Made available in DSpace on 2014-12-14T15:38:03Z (GMT). No. of bitstreams: 1 7913415.pdf: 6017748 bytes, checksum: 5fd8473c17f74152374db059ebae8f73 (MD5) Previous issue date: 1978
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Comparison of Catalogues of Purine-Rich Oligonucleotides From Escherichiacoli and Bacillus Subtilis Ribosomal Ribonucleic Acids
Made available in DSpace on 2014-12-09T22:04:23Z (GMT). No. of bitstreams: 1 7013416.pdf: 1718497 bytes, checksum: cfe43de620c8c53f71e165f15ea412e8 (MD5) Previous issue date: 1969
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Biotin and Fluorescent Labeling of Ribonucleic Acids Using T4 Rna Ligase (Rna Modification, Rna-Dna Hybridization)
The biotin, fluroescein, and tetramethylrhodamine derivatives of P('1)-(6-aminohex-1-yl)-P('2)-(5'adenosine) pyrophosphate were synthesized and used as substrates with T4 RNA ligase. In the absence of ATP, the non-adenylyl portion of these substrates is transferred to the 3'-hydroxyl of an RNA …
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Investigation of the Phylogenetic Relationship of Sporosarcina Ureae to Members of the Bacillaceae Using Primary Structural Characterization of 16s Ribosomal Ribonucleic Acids
Made available in DSpace on 2014-12-14T07:14:42Z (GMT). No. of bitstreams: 1 7616178.pdf: 3880600 bytes, checksum: 0c282ccd25687b115e7bf285bf5a0a0a (MD5) Previous issue date: 1976
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Yeast ribosomes and magnesium ions: a physico-chemical study on the role of magnesium ions in the structure of ribosomes and ribonucleic acids
Contains fulltext : mmubn000001_20837826x.pdf (Publisher’s version ) (Open Access)
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Biochemical investigations on cellular proliferation
… R. Learmonth to examine the relationship between ribonucleic acids (and their derivatives) and the processes of tissue growth (including wound healing).
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Effects of a putative Reb1 protein binding site on IME4 sense and antisense transcription and sporulation in Saccharomyces cerevisiae
… the identification of many different non-coding ribonucleic acids. In the yeast, Saccharomyces cerevisiae, meiosis and sporulation are an important part of the life cycle and IME4 gene expression is required for these processes. IME4 sense transcript levels of expression are influenced by the …
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Biophysical Characterization of the ALS-Linked Protein TDP-43; and Genetic and Small Molecule Rescues from Its Cytotoxicity
… to the trafficking and processing of messenger ribonucleic acids (mRNA) in human cells but is also aggregation prone and has been implicated in amyotrophic lateral sclerosis (ALS). The structure of this multi-domain protein remains unknown, as each domain is linked by a disordered linker region. …
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Development of a Yeast Transcription System Using a Saccharomyces Cerevisiae Enzyme Extract and a Drosophila Melanogaster Histidine tRNA Gene
… processes the 3' terminus of transfer ribonucleic acids. Plasmids containing tRNA genes were a gift from Dieter Soll, Yale University Department of Molecular Biophysics and Biochemistry. In order to provide increasing amounts of the cloned gene, the bacterium Escherichia coli HB101 was …
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An Approach to Analyzing and Predicting Force-extension Curves of Nucleic Acids
… region in force-extension curves of nucleic acids such as long double-stranded deoxyribonucleic acids (DNA) and ribonucleic acids (RNA). The dissertation comprises two parts. In the first part, we propose an approach to help analyze polymer force-extension curves that exhibit a distinct …
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Bioconjugate Strategies for Antisense Therapeutic Delivery to Glioblastoma Stem Cells
… oligonucleotides (AONs) and small interfering ribonucleic acids (siRNAs), are powerful tools for regulating genes, making them a promising therapy for diseases such as cancer where oncogenic genes are over-expressed. The delivery of antisense therapeutics to target cells presents a significant …
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The use of genetic materials, RNA, to determine the age of saliva stains
… of biological stains by means of the analysis of ribonucleic acids such as mixture status, using of RNAlater® stabiliser, were also evaluated. Finally, methods that may be employed to apply the findings to casework, taking into account the level of accuracy achieved, are discussed.
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Investigation of microRNA expression in thyroid carcinoma among South Africa patients
… studies have reported on the effects of micro-ribonucleic acids' (miRNAs) differential expression observed in tumour and normal tissue as another possible marker of thyroid cancer prognosis. Therefore, miRNA expression signatures in thyroid cancer could be used as biomarkers for prognosis and …
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Development of new parameters for structure determination and dynamic investigations on biomacromolecules by NMR
… on the structural as well as dynamic study of ribonucleic acids (RNA). A new structural NMR method was developed aimed at the determination of the glycosidic torsion angle [chi] in RNA, which defines the relative orientation of the nucleobases in respect to the ribose moiety (Duchardt et al., …
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Engineering Lipid Nanoparticle-Mediated Delivery of Nucleic Acids to Lymphoid Organs and Immune Cells
Ribonucleic acids (RNA) and deoxyribonucleic acids (DNA) hold promise for continued application in the treatment of genetic diseases. Short interfering RNA (siRNA) and microRNA (miRNAs) have been used to silence disease-causing genes. Longer messenger RNA (mRNA) and plasmid DNA (pDNA) have been …
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