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Showing 1 to 6 of 6 for “"ribbon-helix-helix"”.
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Elucidating Pseudomonas aeruginosa virulence gene regulation by the ribbon-helix-helix transcription factor AmrZ
… production, among others. AmrZ, a member of the ribbon-helix-helix family of DNA binding proteins, regulates several virulence factors, including alginate biosynthesis, flagellum expression, and type IV pili localization and twitching motility. AmrZ also acts as an autorepressor by binding two …
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Crystallographic studies of the metal-responsive transcription factor NikR
… NikR tetramer, consisting of two dimeric Ribbon-Helix-Helix (RHH) DNA-binding domains separated by a tetrameric regulatory domain that binds metal ions (MBD). NikR is the only known metal- responsive member of the RHH family of transcription factors, and the structural relationships …
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SPECIFIC RESIDUES WITHIN PSEUDOMONAS AERUGINOSA AmrZ ARE REQUIRED FOR TRANSCRIPTIONAL REGULATION OF VIRULENCE FACTORS CONTRIBUTING TO INFECTION
… a strong advantage for survival. AmrZ is a ribbon-helix-helix transcriptional regulator that controls several virulence factors—alginate production, type IV pili expression and twitching motility, and flagellar expression. AmrZ acts as both an activator and a repressor, suggesting it works …
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The evolution and regulation of DNA-binding by the nickel-dependent transcription factor NikR
… transcription factor NikR is a member of the ribbon-helix-helix: RHH) family of DNA-binding proteins and is widespread among bacteria and archea with vastly different nickel physiologies. The goal of this thesis was to better understand basic aspects of cellular transition metal homeostasis by …
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Computational and Experimental Investigation of Allosteric Communication in the Transcriptional Regulator NikR
… and each chain contains both a DNA binding ribbon-helix-helix: RHH) domain and a Ni<super>2+</super> binding regulatory ACT: <underline>a</underline>spartokinase, <underline>c</underline>horismate mutase, <underline>T</underline>yrA) fold. Work herein combines computational modeling of NikR …
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Relating metal binding to DNA binding in the nickel regulatory protein NikR
… tetrameric interface and two flanking dimeric ribbon-helix-helix (RHH) DNA-binding domains. Early work revealed that NikR can bind a variety of transition metal ions and has two binding affinities for the nik operon: nM when stoichiometric Ni2+ binds NikR and pM when excess Ni2+ binds. The …