Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"rho GTP-Binding Proteins"”.
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The Assembly of Pathogenic Signaling Circuits by a Family of Bacterial Secreted Effector Proteins
Bacterial type III secreted effector proteins facilitate Gram-negative bacterial replication, dissemination, and immune evasion in the infected host organism. While much attention has been focused on the cell inhibitory mechanisms of these virulence factors, there is emerging evidence that …
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Localization and Function of Bacterial Type III and IV Effector Proteins
… relay in both space and time. Bacterial effector proteins are virulence factors that are directly secreted from the bacteria into the host cytosol and function to rewire eukaryotic signaling networks to establish an environment for bacterial survival. While much effort has gone into substrate …
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Regulation of Blood Vessel Development via Rho Family GTPase Signaling
The Rho family of small GTPases has been shown to be required in endothelial cells (ECs) during blood vessel formation. However, the underlying cellular events controlled by different GTPases remain unclear. Here, we assess the cellular mechanisms by which Rho family GTPase proteins and their …
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Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective
… is important for regulating axon guidance. Binding of Semaphorin to the Plexin receptor induces the dimerization of Plexin and stimulates its cytoplasmic GAP activity towards Rap, resulting in cytoskeleton re-organization. The growth cone of an axon then turns around, which ultimately leads …