Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"rhinovirus"”.
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Rhinovirus neutralisation and the role of TRIM21
To be added
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Neuroinflammatory consequences of rhinovirus infection in the human airway
Rhinovirus (RV) is the leading cause of exacerbations of airway disease, during which the airways become hypersensitive and manifests clinically with troublesome bouts of cough. The mechanism responsible for respiratory virus induced cough in humans is unknown. This research aimed to determine …
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The regulation and function of viperin during rhinovirus infection
The airway epithelium is the primary site of rhinovirus replication and plays a pivotal role in orchestrating innate immune responses to respiratory viruses, including rhinovirus. Interfacing with inhaled material in the airway lumen, the airway epithelium experiences continuous onslaught from …
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Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
Human rhinovirus (HRV)-induced wheezing illnesses in early life are a major risk factor for subsequent asthma development, and may contribute to induction and progression of airway remodeling (AR) seen in the airways of asthmatic subjects. Thickening of the lamina reticularis is a component of AR …
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The regulation of human airway epithelial expression of viperin by human rhinovirus
Human rhinovirus (HRV) is a major trigger of exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Cigarette smoke is the primary cause of COPD, and 25% of asthmatics smoke. Asthmatic subjects who smoke have more severe disease. Smokers also have more frequent and severe viral …
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Modulation of TGFβ1-induced Fibroblast-to-Myofibroblast Transition in response to Prostaglandin E2 Production by Human Rhinovirus-Infected Airway Epithelial Cells
… marker of myofibroblasts. Given that human rhinovirus (HRV) infections are postulated to be involved in the pathogenesis of airway remodeling in asthma, we originally hypothesized that human airway epithelial cells promoted TGFβ1-induced FMT based on α-SMA expression by secreting mediator(s) …
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A Drug Discovery Study: Inhibitor Design for HRV 3C Protease Based on the Scaffold of (-)-Thysanone
… The common cold, majorly caused by the Human Rhinovirus, still remains one of the major causes of work-loss in industrialised countries and currently only symptomatic treatment is available to treat these viral infections. Thus, even though this illness is not life threatening, a direct …
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The Genetic, Molecular, And Cellular Bases Of Unidentified Primary Immunodeficiencies
… infections with RNA viruses including human rhinovirus, coronaviruses (HKU1, OC43, NL63), influenza virus, and respiratory syncytial virus. The mutant protein lost the ability to bind dsRNA and failed to initiate antiviral interferon-β and pro-inflammatory NF-κB responses. Using gene …
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Klinische Bedeutung und molekulare Epidemiologie von Rhinoviren bei pädiatrischen Patienten des Universitätsklinikums Leipzig
… September 2017 aufgetretenen Infektionen mit dem Rhinovirus bei pädiatrischen Patienten des Universitätsklinikums Leipzig. Betrachtet wurden dabei die molekulare Epidemiologie der RV-Genotypen (n = 777) in diesem Zeitraum sowie die klinische Präsentation der jeweils vorliegenden RV-Infektion. Dies …
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Recommendations for selection efforts to improve the therapeutic quality of Echinacea angustifolia crops in British Columbia
… epithelial (BEAS-2B) cells challenged with rhinovirus. When used in isolation however, pure tetraene alkamide showed a significant inhibitory effect on secretion, thereby further supporting the use of high alkamide production as a selection criterion for therapeutic E. angustifolia cultivar …
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Factors affecting diagnostic and prognostic performance of a transcriptomic signature of risk of tuberculosis in HIV-uninfected South African adults
… in participants with coronavirus, influenza and rhinovirus, respectively, such that RISK11 could not differentiate prevalent tuberculosis from upper respiratory viruses. Compared to RISK11, the Either-Positive test combination decreased diagnostic negative likelihood ratio from 0.7 to 0.3, and …
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Erythrocytes derived microvesicles : their characterisation and potential role as delivery vectors
… HeLa cells and those infected with Human Rhinovirus type 16 derived MV (HRV16iHMV) were used as parallel samples for all experiments. This is because virus infected cell derived EV have been extensively studied and it is understood that viral-MV uses the virus mechanism of entry to …
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Investigations into novel signalling pathways in the response to viral and bacterial infections
… via a physiological activator of TLR7, human rhinovirus 16 (HRV16). TRAM’s role in TLR7 is hypothesised to be dependent on its ability to membrane localise as overexpression of a TRAM myriostoylation mutant which is incapable of membrane localisation dose dependently inhibited TLR7 mediated …
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Inflammation, kinins, and kinin receptors
… to other investigated cells. Further more, rhinovirus induces up-regulation of functional B1 receptors in the same cell type (paper II). Both mechanisms may render the respiratory tract more responsive to generated kinins and can significantly influence the inflammatory response and thereby …
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Identification of potential pathogens of pneumonia in sputum samples from adult patients at the University Teaching Hospital in Lusaka
… 9.4% (17/181) each. Other agents, which included Rhinovirus (5.5%, 10/181), M. catarrhalis (4.4%, 8/181), Pneumocystis jirovecii (3.9%, 7/181), Respiratory Syncytial Virus (RSV) A/B (3.9%, 7/181), Adenovirus (1.7%, 3/181), Human bocavirus (1.1%, 2/181), Human metapneumoviruses A/B (1.1%, 2/181), …
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Identification of potential pathogens of pneumonia in sputum samples from adult patients at the University Teaching Hospital in Lusaka
… 9.4% (17/181) each. Other agents, which included Rhinovirus (5.5%, 10/181), M. catarrhalis (4.4%, 8/181), Pneumocystis jirovecii (3.9%, 7/181), Respiratory Syncytial Virus (RSV) A/B (3.9%, 7/181), Adenovirus (1.7%, 3/181), Human bocavirus (1.1%, 2/181), Human metapneumoviruses A/B (1.1%, 2/181), …
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A Molecular Epidemiological Study of Human Parainfluenza 4 in the Western Cape, South Africa
… respiratory virus with Adenovirus (27 %), Human Rhinovirus (23 %) and Bocavirus (19 %) as the most common. HPIV 1 and HPIV 3 were both able to co-infect patients with HPIV 4, but no co-infections with HPIV 2 were detected. Phylogenetic trees constructed using neighbour joining (NJ) method showed …
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Regulation of hnRNP A1 Cellular Localization by Protein Kinases and its Biological Impact
Human Rhinoviruses (HRVs) utilize Internal Ribosome Entry Sites (IRES) to drive viral protein synthesis. IRESs are specialized RNA elements present within the 5’ UTR of mRNAs that recruit ribosomes independently of the 5’ m7G cap structure. hnRNP A1 (heterogeneous nuclear ribonucleoprotein A1), a …