Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"rhesus macaque"”.
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Investigating clonal hematopoiesis in rhesus macaque and human
… CH mutation landscape in blood cells from aged rhesus macaques (RMs) and to develop an autologous transplantation model of CH in RM to examine the impact of CH and potential therapeutic strategies long term. 2. To assess the impact of CH on COVID-19 disease severity in CH RM model and in human …
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Analysis of Oocyte Quality in the Rhesus Macaque (Macaca mulatta)
… capacity of primate IVM oocytes using the rhesus macaque (Macaca mulatta) as a model. Research efforts included investigation of ovarian senescence, oocyte karyotype and spindle morphology, and establishment of an optimal sperm cryopreservation protocol for use in IVF. Histological …
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The Impact Of Mitochondria On Preimplantation Development In The Rhesus Macaque
… clinics, the use of the NHP has established the rhesus macaque as an excellent research model for human reproduction due to the availability of normal, viable oocytes and embryos from fertile animals. Therefore, the overall goals of this study were to evaluate mitochondria in NHP oocytes and …
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Assessing the Efficacy of Interleukin-7 as an Immunotherapeutic in the SIV+ Rhesus Macaque Model
… Simian immunodeficiency virus (SIV) infection of Rhesus macaques, mimics the disease course of HIV patients and has been used to study HIV pathogenesis and treatment. The goal of this dissertation was to identify a strategy for administering IL-7 to SIV+ anti-retroviral therapy (ART) treated …
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On single-cell immune dynamics of chronic HIV infection and treatment in rhesus macaque models
… and when combined with well-characterized rhesus macaque models of HIV, provides an opportunity to profile immune perturbations over extensive time courses in a controlled setting. In this thesis, I present two studies that further our understanding of the host immune response across stages …
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Distinct Patterns of Ccr5 Versus Alternative Coreceptor Dependence in Non-Natural Host Versus Natural Host Simmian Immunodeficiency Virus Infection
… CD4+ T cell loss. By contrast, non-natural host rhesus macaques experimentally infected with related SIV exhibit high viral loads but display subsequent CD4+ T cell loss and progression to AIDS, analogous to the effects of HIV-1 infection in humans. Several mechanisms have been proposed to …
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A Comparative Study of the Pathology and Pathophysiology of Severe Malaria in a Non-Human Primate Model
… in the Philippines in the early 1960s in Rhesus macaque monkeys and has been evaluated sporadically as a potential platform for comparative studies of Plasmodium falciparum induced severe and cerebral malaria in humans. Using 30 years worth of archival samples at the Armed Forces Research …
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Segmentation of Subcortical Structures from Nonhuman Primate MRI
… two structures from a group of alcohol-dependent Rhesus Macaque monkeys. Using the Level Set Deformable Model (LSDM) with a priori structural information, a series of T1-weighted MR images of Rhesus Macaque hippocampi and striatum were segmented in an effort to compare the structural hippocampal …
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Impact of Thymectomy on the Peripheral T Cell Pool in the Context of SIV Infection
… the development of this technique in the rhesus macaque model and use this method in combination with other techniques to study the role of the thymus in maintenance of the peripheral T cell pool. This study has two major goals: to define the role of the thymus in peripheral T cell …
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Morphogenesis of the lateral geniculate nucleus in primates
… from the eye to the cerebral cortex. In the rhesus macaque monkey, the LGN exhibits an intricate lamination pattern, which changes midway through the nucleus at a point coincident with small gaps due to the blind spot in the retina. This thesis investigates the hypothesis that the …
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Method for acute Neuropixels probe recordings in non-human primates
… use in larger non-human primates (NHPs) such as rhesus macaques has been limited. There are two overarching challenges that impede acute NP implantation in NHPs: (1) traditional microdrive systems that mount to cephalic chambers that are commonly used to access cortical areas for microelectrode …
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On Immunological Imprinting
… conformation and immunodominance. Finally, in a rhesus macaque challenge model, imprinted and heterologous variant-boosted animals were not at a protective disadvantage compared to variant-primed animals. Collectively, this work suggests that though immunological memory significantly shapes …
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Construction of a Simian Immunodeficiency Virus Vaccine from Cynomolgus Macaque Cytomegalovirus
… using a cytomegalovirus based vaccine in the rhesus macaque monkey model have protected close to half of all vaccinated monkeys from SIV, but questions remain as to the mechanism of protection and whether similar results will be seen in humans against HIV. These questions may be answerable …
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Characterization and Development of a Novel Cytomegalovirus for Evaluation as an HIV Vaccine Viral Vector in a Non-Human Primate Model
… (NHP) model, I isolated CMV from cynomolgus macaques (CyCMV), and performed preliminary phenotypic and genomic classification of the novel virus. To characterize the CyCMV genome, facilitate targeted recombination for vaccine construction, and inform possible attenuation strategies, I …
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The Interferon Stimulated Gene Product Lymphocyte Antigen 6 Complex, Locus E Promotes Entry of a Subset of Diverse RNA Viruses and Inhibits Infection by Coronaviruses
… across evolution, as orthologs from bat, rhesus macaque, and mouse exerted a similar effect. To understand the physiological relevance of viral enhancement at the cellular level, I generated Ly6e conditional knockout mice and crossed them to multiple Cre recombinase transgenic mouse …
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Neural Activity Within and Between Visual and Executive Areas Is Modulated Post-Locomotion in Rhesus Macaques
… brain regions are modulated post-locomotion in rhesus macaques.</p> <p>To this end, we performed high-yield electrophysiological recordings simultaneously from area V4, a mid-tier visual cortical region, and the dorsolateral prefrontal cortex (dlPFC), a higher order executive area, while a …
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The Impact of Host Factors on Retroviral Evolution and the Identification of a Novel Receptor That Was Used by an Ancient Primate Retrovirus
… and CERV2, as well as their homologues in the rhesus macaque, bore mutational scars that are characteristic of APOBEC3 activity. A reconstructed CERV2 Gag was used in vitro to confirm that APOBEC3G was capable of restricting CERV2 infection. Therefore, it appears that primate APOBEC3 proteins …
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POST-EXPOSURE TREATMENT OF MARBURG VIRUS ANGOLA DISEASE IN NON-HUMAN PRIMATES USING RECOMBINANT VESICULAR STOMATITIS VIRUS VECTORS
… Musoke strain glycoprotein (GP) of MARV protects macaques against MARV Musoke and Angola variants, as well as Ravn virus. The vector is also effective as a post-exposure treatment against a high dose homologous MARV Musoke challenge. To determine post-exposure efficacy against the most pathogenic …
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Using electrical stimulation for sensory restoration and modulation of attention
… We also present studies in a large animal model (rhesus macaque) to test the feasibility and efficacy of an auditory nerve implant prototype currently being developed for human use. To further explore top-down attentional and behavioral processes, we investigate how microstimulation of the visual …
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Development And Validation Of Novel Transmitted/founder Shivs For Hiv-1 Persistence And Cure Research
… simian-human immunodeficiency virus (SHIV)-rhesus macaque (RM) model of HIV latency and cure is needed. Our group has generated >20 SHIVs encoding various HIV-1 Envs of interest, including transmitted/founder (TF) Envs. TF SHIVs encode a substitution at Env residue 375 that confers …
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