Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 103 for “"rgd"”.
-
Triggerable ligand presentation using caged-RGD
… UV-labile caged-Arginine-Glycine-Aspartic Acid (RGD) ligand and evaluate the effects on cell activities. RGD is the minimal adhesive sequence of fibronectin. By dynamically modulating adhesive ligand presentation, the effects of temporal control on cell processes can be elucidated. In this …
-
RGD based peptide amphiphiles as drug carriers for cancer targeting
… this integrin recognition is the Arg-Gly-Asp (RGD). Self-assembly offers a unique way of presenting ligands to target receptors for recognition and binding. This study focuses on development of integrin specific peptide amphiphile self-assemblies as carriers for targeted delivery of paclitaxel …
-
RGD-targeted Solid Lipid Nanoparticles Containing Asiatic Acid for the Treatment of Cancer
… In this study, arginine-glycine-aspartic acid (RGD) tripeptide was used to target the αvβ3 integrin receptor that is overexpressed by both tumour endothelial cells and various tumour tissues, potentially providing a double-killing (by targeting tumour and tumour endothelial cells) effect. …
-
Structually diverse Cu-64-labeled RGD peptide conjugates for PET imaging of αvβ3 expression
… stability. Structurally diverse bifunctional RGD: arginine-glycine-aspartic acid) peptides were investigated for α<sub>v</sub>β<sub>3</sub> integrin affinity <italic>in vitro</italic> and <italic>in vivo</italic>. The goal of accomplishing higher binding affinity through …
-
Mechanistic studies to evaluate the targeting specificity of novel RGD Micelles to the αVβ3 integrin receptor
… with the Arginine-Glycine-Aspartic Acid (RGD) motif to actively target a <strong>αVβ3</strong> integrin receptors on cancer cells or tumor endothelium. The current work is focused on mechanistic studies to evaluate the uptake of novel RGD amphiphi les with varying alkyl chain lengths …
-
The evaluation of RGD-peptide modified poly(lactic acid-co-lysine) as a resorbable, interactive biomaterial
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
-
The importance of the tissue transglutaminase-fibronectin heterocomplex in the RGD-independent cell adhesion and fibronectin matrix deposition
… leading to the release of the Arg-Gly-Asp (RGD) containing matrix fragments by matrix matelloproteinases (MMPs). These peptides are able to block the interaction between integrin cell surface receptors and ECM proteins, leading to the loss of cell adhesion and ultimately Anoikis. This study …
-
Μεθοδολογίες μοριακής απεικόνισης με επισημασμένα νανοσωματίδια για τον ποσοτικό προσδιορισμό της χωροχρονικής κατανομής της αγγειογένεσης σε καρκινικούς όγκους
… απεικόνισης. Ένα νέο κυκλικό πεπτιδικό παράγωγο RGDfK (Arg-Gly-Asp-D‐Phe–Lys), το cRGDfK-Orn3-CGG, αξιολογήθηκε ως νέο μοριακό μέσο στόχευσης του καρκίνου μέσω της ειδικής στόχευσης των υποδοχέων ιντεγκρίνης ανβ3 που υπερεκφράζονται κατά την αγγειογένεση. Το νέο πεπτιδικό παράγωγο φέρει τον …
-
Cell surface interactions of Coxsackie A9 virus
… harbours an integrin- recognition motif, RGD (Arg-Gly-Asp), in the capsid protein VP1 and although modes of transmission and pathogenesis are still largely unknown, this motif is believed to be primarily responsible for integrins αvβ6 and αvβ3 binding. The conservation of the RGD +1 …
-
The Role of Anti-Viral Immune Response on the Therapeutic Efficacy of Oncolytic Virotherapy for High-Grade Gliomas
… these viruses, the oncolytic adenovirus Delta-24-RGD has shown safety and efficacy in clinical trials for high-grade gliomas. Strategies to improve the efficacy of oncolytic virotherapy have aimed to heighten the immunogenicity of oncolytic viruses, either by incorporating immune-stimulating …
-
Effekt einer Antagonisierung der alpha- v-Integrine auf Angiogenese, Wachstum und Metastasierung solider Tumoren in vivo
… of alpha-v-integrins with a methylated cyclic RGD-peptide on angiogenesis, microcirculation, growth and metastasis formation of a solid tumor in vivo. Methods: Experiments were performed in the dorsal skinfold preparation of Syrian Golden hamsters bearing the amelanotic hamster melanoma …
-
Bone Marrow Stromal Cell Invasion and Bone Regeneration in Enzymatically-Degradable Osteoinductive Hydrogels
… part, the effect of conjugation of cell adhesion RGD peptide and osteogenic peptide KIPKA SSVPT ELSAI STLYL to a model biodegradable hydrogel on osteogenic differentiation of BMS cells and production of mineralized matrix was studied. RGD peptide was grafted to the hydrogel by adding acrylated RGD …
-
Investigations into the Neuroprotective Effects of Osteopontin in In Vitro and In Vivo Models of Parkinsons Disease
… may be mediated through interactions between the RGD binding domain of OPN and integrin receptors resulting in an attenuation of reactive gliosis and the production glial-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF). Therefore, the aim of these studies was to …
-
The development of small molecule inhibitors for fibrosis drug discovery
… including the enzyme autotaxin (ATX) and the RGD integrins, which are known to play a key role in the pathogenesis. In collaboration with GlaxoSmithKline, the projects detailed in this report were aimed to develop small molecule inhibitors with drug like physicochemical properties for fibrosis …
-
Peptide hydrogels as novel scaffolds for dental pulp cell culture
… motifs, such as Arginine-Glycine-Aspartate (RGD). The use of hydrogel scaffolds is gaining popularity in regenerative endodontics whereby they can be used in combination with stem cells, derived from the dental pulp (DPCs), and/or growth factors for regeneration of the dentine-pulp complex. …
-
Modulation of Endothelial Cell Adhesion to Synthetic Vascular Grafts Using Biotinylated Fibronectin in a Dual Ligand Protein System
… bFN and ELISA to detect the availability of the RGD binding motif post biotinylation. The second major change in this project examined cell binding and formation of focal adhesion after shifting from direct incubation of HUVECs with RGD-SA to sequentially adsorbing bFN(9) and RGD-SA prior to …
Page 1 of 6