Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"rewiring"”.
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Carbon Starvation Metabolically Regulates Chromatin for Transcriptome Rewiring
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
Pancreatic cancer (PC) is a lethal malignancy characterised by chemoresistance and metastatic spread. This is largely due to the presence of dense stromal fibrosis which distorts tumour vasculature. This limits nutrient, oxygen and chemotherapy perfusion into pancreatic tumours and promotes …
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Defining and Targeting Epigenetic Rewiring During Tumor Progression
… recurrent tumor epigenetic and transcriptional rewiring conferred sensitivity to G9a inhibitors. G9a inhibition promoted recurrent tumor cell necroptosis through demethylation of genes involved in a pro-inflammatory cytokine program. Further, knockout of G9a protein delayed the time until …
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The role of metabolic rewiring in endocrine resistance
Breast cancer is the most common cancer type in women population affecting a large number of women worldwide. Due to its highly heterogenous molecular characteristics, there is not a default treatment strategy for breast cancer. Almost two third of breast cancer cases are estrogen receptor positive …
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Biotic and Abiotic Drivers of Plant-Pollinator Interaction Rewiring
… for geographic distance to indirectly impact rewiring. Second, I use a multinomial logistic regression to show that pollinators prefer different flowers at different temperatures, even within a constant plant community. Third, I present an experimental manipulation that connects the removal of …
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SURVIVING UNDER PRESSURE: TRANSLATIONAL REWIRING IN RESPONSE TO MECHANICAL STIMULI
An outcome of high mechanical stress in the context of hyperproliferation and increased cellular tension is the reduction in cell volume, that holds the potential to impact cellular density. Both cell size and density homeostasis are integral features of healthy tissues, intricately linked to the …
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Rewiring The Anger: Learning New Responses In The Therapeutic Community
Extensive research has been conducted in correctional settings on the effects that therapeutic programs that utilize cognitive-behavioral therapies have on recidivism rates and cognitive-behavioral changes among inmates. Research on anger management programs in correctional settings has shown that …
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Rewiring the Spokes: The Future of U.S. Bilateralism in Asia
<p>Since the end of WWII, multilateralism has consistently grown as the go-to alliance structure for the United States. Despite this, the U.S. opted to create a series of bilateral alliances after WWII in Asia, dubbed the Hub-and-Spokes system. This alliance system has not only sustained itself, …
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Rewiring the Text: Adaptation and Translation in the Digital Heteroglossia.
This dissertation is concerned with adaptation, in the context of new emerging digital media platforms. The project proposes that new media has allowed for the creation of a universal digital heteroglossia; a heteroglossia that contains the plurality of the unstable utterances of cinema, radio, …
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Rewiring neural conduits : engineering neuromuscular tissues for bidirectional neuroprosthetic interfacing
… paradigm towards one that performs strategic rewiring of neuromuscular constructs to enable improved neurological health and neural interfacing.
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MULTI-OMICS PROFILING DECODES BACE2-DEPENDENT METABOLIC REWIRING IN METASTATIC MELANOMA
BACE2 has traditionally been studied in the context of neurodegenerative diseases. However, its involvement in cancer progression has become increasingly recognized. While in melanocytes, BACE2 physiologically cleaves the PMEL protein to generate peptides that form the melanin scaffold, our group …
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An integrated approach to understanding the metabolic rewiring of cancer cells
… begun to appreciate the extent of metabolic rewiring required to sustain the uncontrolled growth of tumors. Cancer metabolism is now an active area of research, and efforts are underway to expand the range of oncology diagnostics and therapeutics through targeting metabolism. Despite this …
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Differential Dependency Network and Data Integration for Detecting Network Rewiring and Biomarkers
… in biological networks, also known as network rewiring. Genes with a large number of rewired edges are more likely to be associated with functional alteration leading phenotype transitions, and hence are potential biomarkers in diseases such as cancers. Differential dependency network (DDN) …
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Knowledge-fused Identification of Condition-specific Rewiring of Dependencies in Biological Networks
… Among the network construction tasks, the rewiring of relevant network structure plays critical roles in determining the behavior of diseases. To systematically characterize the selectively activated regulatory components and mechanisms, the modeling tools must be able to effectively …
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Investigation of Age Related Differences in the Rewiring of P2-Olfactory Receptor Neurons
Olfactory receptor neurons (ORNs) maintain the ability to regenerate. These neurons reside in the olfactory epithelium and project axons that connect to the olfactory bulbs. Despite the diffuse distribution of ORNs in the olfactory epithelium, they converge at discrete glomeruli in the olfactory …
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A Hybrid Approach to Network Robustness Optimization using Edge Rewiring and Edge Addition
… of accomplishing this task, including edge rewiring and edge addition. Both of these methods can be very useful for optimizing network robustness, but each comes with its own set of limitations. This thesis proposes a new hybrid approach to network robustness optimization that combines both …
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Directed Migration Achieved in Mammalian Cells via Ca2+ Signal Rewiring in Synthetic Protein Chimeras
Synthetic biology achieves control over cellular behavior by endogenous re-wiring. Ca2+ signals allow cells to regulate diverse processes such as migration, apoptosis, motility and exocytosis. In some receptors (e.g. VEGFR2), Ca2+ signals are generated upon ligand binding (e.g. VEGF-A). Here, …
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Rewiring anaerobic digestion: production of biofuel intermediates and high-value chemicals from cellulosic wastes
Anaerobic Digestion (AD) is a mature biotechnology for the valorization of organic residues, and AD is one of the most popular technologies for organic carbon recovery and waste stabilization. Research and applications for this process have been focused on the production of methane-containing …
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Unraveling Epigenetic Mechanisms That Regulate Breast Cancer Lung Metastatic Relapse by Rewiring the Immune Microenvironment
<p>Metastasis accounts for >90% of cancer-related deaths and thwarting metastasis is widely considered to be the “Holy Grail” of cancer treatment. Breast cancer is the most common cause of cancer-related death among women and is characterized by its proclivity to spread to distant secondary organs …
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