Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 12511 for “"reveal"”.
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Dactyls reveal evolutionary patterns in decapod crustaceans
Because of their high preservation potential and uses in foraging and defense, decapod crustacean dactyls (movable fingers of claws) are potentially excellent test subjects for an ongoing debate concerning the relative importance of top-down (predators) and bottom-up (prey) controls on morphologic …
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Naturalistic Visuomotor Behaviours Reveal Reduced Handedness Lateralization In Autism
… in 3D space use. Movement trajectory analyses revealed more idiosyncratic action sequences and slower completion times compared to non-autistic participants, reflecting reduced motor efficiency. These findings demonstrate reduced specialization of hand use in autism, which may contribute to …
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Reverse genetic approaches reveal gene redundancy in Arabidopsis anthers
… and of pollen development. Moreover, this work reveals the untapped potential of reverse genetics to predict redundant relationships between paralogs in well-studied model organisms.
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Deep learning and coevolution reveal proteome-wide protein-protein interactions
The total set of potential protein-protein interactions (PPI) within an organism's proteome guides a plethora of potential biological processes at an organism’s disposal. Understanding these PPIs is critical to our understanding of biological systems, however identifying interactions with high …
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Engineered Cytoskeletal Arrays Reveal Mechanisms Of Membrane Transport And Tubulation
Within the cell, cytoskeletal molecular motors transport and remodel membrane-bound cargos along microtubule and actin filament tracks. Typically, there are multiple actin and microtubule motors attached to the same cargo, which must coordinate to navigate a complex cytoskeletal environment and …
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Genomic studies of oocyte physiology reveal mechanisms critical to oocyte competence
In vitro maturation of porcine oocytes has been intensively studied for many years. However, the in vitro maturation system is still inefficient to produce competent oocytes that can develop to viable embryos. The studies discussed in this dissertation attempt to use different techniques and …
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The Search for Meaning: What Do the Narratives of Grieving Individuals Reveal?
… before the interviews. Findings of this research reveal the unique and complex grieving processes of the participants. A variety of meanings were assigned to the losses with each meaning having its own possible impact on the course of bereavement. Each participant expressed her/his own personal …
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SPINAL MUSCULAR ATROPHY ORGANOIDS REVEAL DEVELOPMENTAL DEFECTS RESCUED BY ANTISENSE OLIGONUCLEOTIDES TREATMENT
… features. Single-cell transcriptomics revealed a pervasive transcriptional alteration in multiple cell populations, along with drastic changes in motor neuron gene expression. Morphological analyses detected early differentiation defects in SMA SCOs, unveiling a significant …
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Silicon Oxide Nanoparticles Reveal the Origin of Silicate Grains in Circumstellar Environments
… species; however there are no studies to reveal the microscopic mechanism. We have used a synergistic approach combining experiments in molecular beams and first principles theoretical calculation to demonstrate that the passage from SiO to Si02 proceeds via gradual oxygen enrichment of …
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Single-molecule studies reveal mechanisms of human DNA double-strand break repair
DNA damage is ubiquitous to all organisms and very complex pathways have evolved to recognize and repair these lesions. The most deleterious DNA damages are double-strand breaks (DSBs), and a single unrepaired DSB can lead to cell death. In human cells, there exist two canonical pathways of DSB …
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Denoising techniques reveal neural correlates of modulation masking release in auditory cortex
… best denoising performance. Denoised spike train reveals a robust correlation of spike rate with behavioral performance. Results hint that neural correlates of MMR are not primarily based on spike rate coding, at least in the core auditory cortex.
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Multi-omic Studies of Neutrophils Reveal Programmed Deactivation Phenotypes After Inflammatory Stimulus
… functions. Analysis of the phosphoproteome revealed a bimodal response pattern characterized by peak phosphorylation or dephosphorylation at 15 and 120 minutes, indicating distinct early and late phases of response. Within the enriched pathways associated with phosphorylated proteins, …
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Discover. Reveal. Educate.: Making a School for Bluegrass Music in Floyd, Virginia
… as the street. The moment in which a musician reveals or explores this inspirational material can be a private one, most likely to take place in the individual rooms of the residential buildings. The most important occasion, education, takes place as it has for centuries - within conversation. …
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Combined experimental and modeling studies reveal new mechanisms in T cell antigen recognition
T cells of the immune system recognize small antigen peptide fragments loaded onto Major Histocompatibility Complex (pMHC) molecules through their T Cell Receptor (TCR). The recognition of antigenic pMHC by the TCR is an extremely sensitive and specific process, discriminating as few as a single …
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Single-cell approaches reveal functional and molecular heterogeneity in malignant haematopoietic stem cells
… expression profiling of JAK2 V617F-mutant HSCs revealed reduced expression of specific self-renewal regulator genes, some of which were restored to normal levels in single TET2/JAK2 mutant HSCs. Of these, Bmi1 and, to a lesser extent, Pbx1 and Meis1 overexpression in JAK2-mutant HSCs could …
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Novel Structures of RAD51 Reveal Mechanisms in DNA Damage Repair and Genomic Stability
… with biochemical and biophysical data that reveal new insights into how RAD51 contributes to maintaining the stability of our genome. High-resolution structures of RAD51 filaments on single- (ss-) and double-stranded (ds-) DNA revealed the presence of a second metal cation at the ATP-binding …
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Integrated Multimodal Genomic Analyses Reveal Novel Mechanisms of Glucocorticoid Resistance in Acute Lymphoblastic Leukemia
<p>Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Much has been discovered in recent decades regarding ALL biology, and the outcome of patients with ALL has vastly improved, especially in pediatric ALL patients. Despite very promising overall cure rates, patients who …
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Polarized Bow Shock Nebulae Reveal Features of the Winds and Environments of Massive Stars
<p>Massive stars strongly affect their surroundings through their energetic stellar winds during their lifetime and through their energetic deaths as supernovae. When a stellar wind interacts with the local interstellar medium (ISM), if the relative velocity between wind and ISM is supersonic, then …
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