Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 269 for “"retroviral"”.
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Mechanisms of retroviral replication
… of viral RNA is an essential step of retroviral replication cycle. Extensive biochemical and genetic analyses suggest that majority of retroviruses employ similar mechanisms for specific RNA packaging. Better understanding of mechanisms of this process may help to develop new …
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Trans-Acting Factors Affecting Retroviral Recoding
The production of retroviral enzymes requires a translational recoding event which subverts normal decoding, either by direct suppression of termination with the insertion of an amino acid at a stop codon (readthrough), or by an alteration of the reading frame of the mRNA (frameshift). It has been …
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Gene expression studies using retroviral vectors
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 1986
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Design of hybrid retroviral/synthetic gene delivery vectors
… for a modified trafficking mechanism of the retroviral particle but also modulates the kinetics of delivery of the retrovirus to the nucleus for efficient expression of the target gene.
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Role of Ubiquitin and Ubiquitin Ligases in Retroviral Budding
… final stage in the production of infectious retroviral particles is the scission of membrane tethers connecting nascent virions to the host cell. Efficient retrovirus release requires late domains, short peptide motifs within the structural Gag proteins that engage the cellular Class E …
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Insertional mutagenesis in zebrafish using a pseudotyped retroviral vector
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Role and specificity of regulatory T cells during retroviral infection
… mice with Friend virus (FV). FV is a murine retroviral complex, which causes non-cytopathic persistent infection of hematopoietic cells. The results obtained suggested that unregulated CD4+ T cell response to FV causes bone marrow pathology and anaemia. Regulatory T (Treg) cells are a subset …
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Retroviral-Medicated Transfer of Suppressor tRNA Genes Into Human Cells
… constructed using oligonucleotides. Retroviral vectors were selected for delivery to human target cells in order to stably integrate the suppressor tRNA into the target cells' genome. Recombinant retroviral vectors were used to transfect retrovirus packaging cells and produce …
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Molekulare Analysen zur Pluripotenz und Langzeitaktivität retroviral transduzierter hämatopoetischer Stammzellen
… untersucht. Die genomische Integrationsstelle retroviraler Vektoren ist ein stabiler individueller DNA-Marker für jede transduzierte Zelle. Aus Leukozyten-DNA des Rhesusaffen wurden mehr als 80 Integrations-stellen durch ligationsmediierte PCRs identifiziert. Um aus dieser polyklonalen …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… novel therapeutic target as well as testing anti-retroviral drugs’ efficacy for the treatment of these tumours. I have demonstrated that HERV-K (HML-2) Env overexpression (Env o/e) in primary Schwann cells resulted in increased proliferation and elevated expression of the transcription factor …
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Restriction of Retrotransposition and Retroviral Infection by RNase L and APOBEC3G
… yet complex control of retrotransposition and retroviral Infection by host restriction factors RNase L and APOBEC3G.
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Regulation of Expression of a Retroviral Transforming Gene and its Cellular Homolog
<p>This thesis has focused on the avian Fujinami sarcoma virus (FSV) and its role in transformation. Specifically, it included the biochemical characterization of temperature-sensitive (ts) mutants of FSV, the identification of the product of a cellular gene homologous to the transforming gene of …
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Identification and Knockout of Immunodominant Endogenous Retroviral Antigen in Murine Tumor Models
Advances in cancer immunotherapy have demonstrated the dominant role of T cells in an anti-tumor response, but the functional role of B cells and their antibodies in cancer remains less clear. In murine tumor models, curative immunotherapies have been previously shown to result in the development …
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Factors associated with adherence to anti-retroviral therapy in Katima Mulilo hospital, Namibia
… due to the disease. The introduction of anti-retroviral therapy (ART) in public health facilities in Namibia in 2003 has improved the quality of lives of patients with advanced HIV disease, prolonged their lives and enabled them to be economically productive. By 2010 about 90,000 patients were …
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Retroviral-mediated gene transfer of Il-1β?cDNA into human activated T cells
… (IL-Iβ) cDNA inserted into the MFG retroviral vector served as an indicator gene in these studies. Optimized methodologies resulted in T cell transduction frequencies of approximately 50-75%. An important consideration for the success of T lymphocyte-based gene therapy is the …
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The formulation and stability of dispersible or chewable tablets containing anti retroviral drugs
… and Zidovudine (AZT) is indicated as part of antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infected adults and children who present clinical or immunological evidence of progression of the disease. Current dosage forms of these drugs in single or …
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In vivo Detektion und Quantifikation retroviral markierter humaner hämatopoetischer Stammzellklone in der Gentherapie
… dar. Seit Anfang der 1990er Jahre wird onkoretroviraler Gentransfer in T-Lymphozyten, Nabelschnurblut- und Knochenmarkszellen zur Behandlung von schweren kombinierten Immundefizienzen (SCID) eingestezt. Während der SCID-X1 sowie neuerdings auch der ADA-SCID gentherapeutisch geheilt werden …
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Qualitative und quantitativ-kompetitive in vivo Longitudinalanalyse retroviral transduzierter CD34+ Zellen im Pavianmodell
Retrovirale Vektoren können infolge ihrer stabilen und näherungsweise zufällig in das zelluläre Genom verteilten Integration als Klonalitätsmarker verwendet werden. Jede transduzierte Zelle und ihre Nachkommen werden durch ihre individuelle viral-genomische Fusionssequenz charakterisiert. Gelingt …
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Proteomic insights into the modulation of foetal neurogenesis by the anti-retroviral efavirenz
… pregnant women immediately initiate antiretroviral therapy (efavirenz, emtricitabine, and tenofovir), regardless of trimester. Efavirenz causes central nervous system neuropathy and has been linked to birth defects such as encephalocoele. Cohort studies of HIV-uninfected children exposed …
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Factors contributing to clients defaulting anti-retroviral treatment at Matoks Capricorn District, Limpopo Province
Background: The provision of antiretroviral treatment for people living with HIV/AIDS has encountered many challenges associated with poor adherence in South African and other countries in Africa as a whole including globally. Taking ARVs Properly has shown to reduce viral load to a level where the …
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