Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"retrotransposon"”.
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Retrotransposon-mediated instability in the human genome
… Element-1/L1) and Alu are two active retrotransposon families in the human genome that have the potential to create genomic instability either during the insertion of new elements or through ectopic recombination. However, recent in vitro analyses have demonstrated that these elements …
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Isolation and Characterization of a Full Length Retrotransposon: CR1
<p>Transposable elements (TE) have been found in all genomes and have clearly had a major impact on genomic evolution. The described research takes advantage of an abundant transposable element present in the genomes of Anseriformes, called Chicken Repeat 1 (CR1). Previous studies in Anseriformes …
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Retrotransposon mediated genomic fluidity in the human and chimpanzee lineages
… are highly successful non-long terminal repeat retrotransposons with copy numbers of ~520,000 and >1 million within the human genome, respectively. They are associated with human genetic variation and genomic rearrangement. Although they are abundant throughout primate genomes, their propagation …
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A proteomic approach for studying LTR retrotransposon host factors in saccharomyces cerevisae
The Ty retrotransposons of S. cerevisiae are mobile elements that resemble retroviruses, both in their genetic structures and replication cycles. Ty retrotransposition begins in the nucleus with the transcription of Ty RNA. Following translation of Ty proteins, virus-like particles (VLPs) assemble …
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Magnaporthe Oryzae Telomeric Retrotransposon (moter) Relics Further Highlight Telomere Dynamics In A Rapidly Evolving Fungal Pathogen
… are frequently attributed to the presence of two retrotransposons (MoTeR 1 and MoTeR 2) that are endemic to the telomeres. These rearrangements can leave footprints within the interior of the genome that document previous telomere breakage events. The purpose of this study was to examine MoTeR …
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Somatic retrotransposition in the cancer genome
… genome-wide using computational algorithms. Retrotransposons comprise 42% of the human genome and have the capacity to "jump" across the genome in a copy-and-paste manner. Recent studies have identified families of retrotransposable elements that are currently active. In fact, …
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A comparative study of the expression of LINE, mys and SINE retrotransposon loci in somatic and germ-line tissues in peromyscus maniculatus
<p>This study was to determine if one or more loci are serving as a master gene for the amplification of LINE, ID, and <em>mys</em> elements, which mobilize via RNA, in <em>Peromyscus maniculatus</em> tissues, by the use of the RT-PCR technique. It was concluded that potentially more than one …
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Molekulare Charakterisierung des Retrotransposons Ylt1 der Hefe Yarrowia lipolytica
Die Retrotransposonen sind ubiquitäre Komponenten des eukaryotischen Genoms. In der Hefe Yarrowia lipolytica existiert neben anderen Retrotransposonen das Retrotransposon Ylt1 (Yarrowia lipolytica retrotransposon). Dieses Retrotransposon besteht aus den flankierenden "Long Terminal …
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The identification and characterization of inter- and intra-species genetic diversity derived from retrotransposons in humans
Retrotransposons, which used to be considered as “junk DNA”, have begun to reveal their immense value to genome evolution and human biology due to recent studies. They consist of at least ~45% of the human genome and are more or less the same in other mammalian genomes. Retrotransposon elements …
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The Contribution of Retrotransposons to the Transcriptomes of Murine Somatic Cells
Retrotransposons comprise approximately 40% of the mouse genome. Once thought to be useless “junk” DNA, there is growing evidence that retrotransposons play crucial roles in genome evolution and gene regulation, and contribute to the transcriptome. Several studies have found functional …
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Prediction of Dna Methylation Based On Genomic Architecture and Applications of Positional Weight Matrices
… that the genetic architecture based on retrotransposon elements surrounding the transcription start site, plays an important role in the suppression and promotion of DNA methylation. In our investigation we found a high rate of SINE and LINEs retrotransposon elements near the …
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Development of intermonoploid somatic hybrids of potato and their molecular analysis based on polymorphism for retroelement Tst1
… the use of a defined genomic sequence, e.g., retrotransposon display (RD) when the defined sequence is anchored into a consensus sequence of a retrotransposon such as the long terminal repeat (LTR) sequence of Tst1. Parental monoploids, SH and various Solanaceae were evaluated by RD. …
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Observing and quantifying transposable element activity inside living cells
… We also find that the activity of the human retrotransposon LINE-1 is lethal to bacterial cell growth, and propose that transposable element activity may have played a role in the early evolution of eukaryotes. Again, by quantifying how LINE-1 expression decreases bacterial growth rate, we …
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Mosquito Transposable Elements and piwi Genes
… first subject is on a Long Terminal Repeat (LTR) retrotransposon in the African malaria mosquito, Anopheles gambiae, namely Belly. The second subject focuses on the characterization of piwi genes in the dengue and yellow fever mosquito, Aedes aegypti. For the first subject we characterized Belly …
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Molekulare Charakterisierung von Ty3-gypsy-Retrotransposons als abundante Sequenzklasse des Centromers eines Minichromosoms in Beta vulgaris L.
… die molekulare Charakterisierung von Ty3-gypsy-Retrotransposons eines einzelnen Wildrüben-Centromers möglich. Die für die Wildrübe Beta procumbens spezifischen Satellitenrepeats pTS5 und pTS4.1 dienten der Selektion von BACs aus der Centromer-Region des PRO1-Minichromosoms. Die Identifizierung …
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Molecular mechanism of KAP1-dependent transcriptional silencing
… TRIM28 or TIF1β). Following its recruitment to retrotransposons by sequence-specific KRAB domain-containing zinc finger proteins (KRAB-ZFPs), KAP1 induces the assembly of an epigenetic silencing complex, with chromatin remodeling activities that repress transcription of the targeted …
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Regulation of the ETn/MusD family of active mouse long terminal repeat retrotransposons
Long terminal repeat (LTR) retrotransposons account for approximately 10% of mouse and 8% of human genomes and may play a role in modifying gene expression. Many species harbor retrotransposon families encompassing both autonomous and non-autonomous members. Specifically, the mouse Early Transposon …
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Bioinformatic analysis: Retroposon sequences containing multiple putative endonucleases
… (SLACS) of T. brucei, c ruzi-associated retrotransposon (CZAR) of Trypanosoma cruzi, two crithidia retrotransposable elements (CRE); CRE1 and CRE2 of Crithidia fasciculata , and certain ING retroposon sequences of Trypanosoma brucei contain multiple putative endonuclease functions.
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Evolution of the mysRS element in the genome of rodent species
<p>Retrotransposons are a type of transposable element in which DNA copies are produced via an RNA intermediate and integrate into new chromosomal sites continually contributing to the dynamics of genomes. While sequencing the mys element among the Cricetidae family of rodents, we identified a …
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