Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"retromer complex"”.
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The functional role of the retromer complex in the pathogenesis of Alzheimer's disease in Down syndrome
… of the endosomal-sorting system known as the retromer complex. Mechanistically, retromer dysfunction can influence amyloid beta production by increasing interaction of the retromer cargo APP with beta-secretase. However, recent studies have also implicated the retromer complex in the …
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Endosomal membrane dynamics underlying cell spreading: A role for the small GTPase Arf6
… membranes to the plasma membrane involves the retromer complex, a coat-like multi-protein complex primarily known for mediating retrograde transport from endosomes to the trans-Golgi network. Altogether, my studies have confirmed genetically, an involvement of Arf6 in cell spreading and raft …
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Structure/Function Studies on Vps9 domain-containing Ankyrin Repeat protein (VARP)
… tether golginA4, the kinesin motor Kif5a and the retromer complex subunit Vps29. The retromer core complex, comprising Vps35, Vps26, and Vps29, utilises different SNX proteins to mediate both Endosome to Golgi traffic, and Endosome to Plasma membrane traffic. The interaction of Varp with Vps29 …
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Somatostatin Receptor 2 Regulation By C-Terminal Motifs and Pdz Domain Proteins
… dependent upon an intact C-terminal tail and the retromer complex of endosomal coat proteins. Additionally, removing either 3 or 10 C-terminal amino acids from sst2 alters the pathway through which sst2 recycles to the plasma membrane. We also determined that the expression of SHANK3, a PDZ domain …
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The interrelationship between the endosomal sorting regulators RAB21, Retromer and WASH complex
… The early endosome recruits several sorting complexes namely retromer, commander and WASH complex to facilitate the proper trafficking of cargo. The sorting complexes such as WASH and retromer complex are known to interact with each other and influence each other’s endosomal localisation. The …
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Sensory Organ Morphogenesis in Caenorhabditis Elegans
… size. Finally, I also identify a role for the retromer complex, a module involved in the recycling of transmembrane proteins and membrane material from the endosomes to the Golgi apparatus, in amphid morphogenesis. Similar to lit-1, mutations of retromer components suppress daf-6, suggesting …
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PROTEINi screens identify ORP9 as a novel regulator of KRAS-driven signalling
… co-localised with YFP-VPS29, a component of the retromer. The retromer is a coat complex that interacts with specific internalised cargo, budding off from early/late endosomes to deliver cargo back to the plasma membrane. This recycling relies on WASH-mediated actin nucleation for membrane …
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Investigations into the Nature of the Endosomal System in Plasmodium falciparum
… protein components of the late endosome, the retromer cargo-selective complex and Rab7, were found on a previously un-described inherited structure adjacent to the parasite Golgi apparatus and in close opposition to nascent rhoptries (specialized secretory organelles required for invasion). …
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DESIGN, SYNTHESIS AND BIOLOGICAL PROFILING OF NEW COMPOUNDS: INFECTIOUS AND NEURODEGENERATIVE DISEASES AS TARGETS
… the binding affinity of these compounds for the retromer complex at the critical Vps35-Vps29 interface, thereby bolstering their potential therapeutic efficacy. Concurrently, I rigorously pursued strategies to minimize off-target effects, particularly concerning interactions with the 5-HT …