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Showing 1 to 16 of 16 for “"retromer"”.
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Functional Connection Between Yeast Dynamin and Retromer at the Endosome
… regulated by a family of proteins known as the "Retromer” composed of 5 VPS proteins (Vps5, Vps17, Vps26, Vps29, and Vps35). Retromer acts as the coat proteins for vesicles emerging from late endosomes. Loss of Retromer function has been previously implicated in both Parkinson's and Alzheimer's …
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Biochemische und zellbiologische Charakterisierung des Retromer-vermittelten Proteintransports in Pflanzen
… pentameren Proteinkomplexes, dem sogenannten Retromer. Dieser Komplex wird an die Membran des PVC rekrutiert und bindet die Hydrolase-Rezeptoren. Der Retromerkomplex besteht aus zwei Subkomplexen, einem großen aus Vps35, Vps26 und Vps29 und einem kleinen aus Vps5 und Vps17 (vps für vacuolar …
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The interrelationship between the endosomal sorting regulators RAB21, Retromer and WASH complex
… recruits several sorting complexes namely retromer, commander and WASH complex to facilitate the proper trafficking of cargo. The sorting complexes such as WASH and retromer complex are known to interact with each other and influence each other’s endosomal localisation. The sorting …
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The functional role of the retromer complex in the pathogenesis of Alzheimer's disease in Down syndrome
… of the endosomal-sorting system known as the retromer complex. Mechanistically, retromer dysfunction can influence amyloid beta production by increasing interaction of the retromer cargo APP with beta-secretase. However, recent studies have also implicated the retromer complex in the …
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PROTEINi screens identify ORP9 as a novel regulator of KRAS-driven signalling
… co-localised with YFP-VPS29, a component of the retromer. The retromer is a coat complex that interacts with specific internalised cargo, budding off from early/late endosomes to deliver cargo back to the plasma membrane. This recycling relies on WASH-mediated actin nucleation for membrane …
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Sensory Organ Morphogenesis in Caenorhabditis Elegans
… size. Finally, I also identify a role for the retromer complex, a module involved in the recycling of transmembrane proteins and membrane material from the endosomes to the Golgi apparatus, in amphid morphogenesis. Similar to lit-1, mutations of retromer components suppress daf-6, suggesting …
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Structure/Function Studies on Vps9 domain-containing Ankyrin Repeat protein (VARP)
… tether golginA4, the kinesin motor Kif5a and the retromer complex subunit Vps29. The retromer core complex, comprising Vps35, Vps26, and Vps29, utilises different SNX proteins to mediate both Endosome to Golgi traffic, and Endosome to Plasma membrane traffic. The interaction of Varp with Vps29 …
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Einfluss von Gibberellin auf den Gravitropismus der Wurzel durch Regulation der PIN-Stabilität
… Endosomen gesteigert war. Um zu testen, ob der Retromer-abhängige Weg für den GA-induzierten Anstieg der PIN-Proteine an der Plasmamembran notwendig ist, wurden die Versuche im Hintergrund einer snx1-Mutante wiederholt, in der das Retromer-abhängige Recycling unterbrochen ist. In dieser Mutante …
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Investigations into the Nature of the Endosomal System in Plasmodium falciparum
… protein components of the late endosome, the retromer cargo-selective complex and Rab7, were found on a previously un-described inherited structure adjacent to the parasite Golgi apparatus and in close opposition to nascent rhoptries (specialized secretory organelles required for invasion). …
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Endosomal membrane dynamics underlying cell spreading: A role for the small GTPase Arf6
… membranes to the plasma membrane involves the retromer complex, a coat-like multi-protein complex primarily known for mediating retrograde transport from endosomes to the trans-Golgi network. Altogether, my studies have confirmed genetically, an involvement of Arf6 in cell spreading and raft …
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Investigation of early endosomal sorting and budding
… beeinträchtigt, während Antikörper gegen den Retromer Komplex den Prozess blockieren. Darüber hinaus benötigt der Prozess die endosomalen Proteine Rab5, Phosphatidylinositol-3-Phosphat und überraschenderweise auch den Dockingfaktor EEA1. Des Weiteren wird die Funktion des …
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IGDB-2, an IG/FNIII Protein, Binds the ION Channel LGC-34 and Controls Sensory Compartment Morphogenesis in C. Elegans
… size. LIT-1, a Nemo-like kinase, and SNX-1, a retromer component, antagonize DAF-6 and promote compartment expansion. My work here further explores the machinery underlying compartment size control. In seeking genes whose inactivation restores normal compartment size to daf-6 mutants, I …
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Somatostatin Receptor 2 Regulation By C-Terminal Motifs and Pdz Domain Proteins
… dependent upon an intact C-terminal tail and the retromer complex of endosomal coat proteins. Additionally, removing either 3 or 10 C-terminal amino acids from sst2 alters the pathway through which sst2 recycles to the plasma membrane. We also determined that the expression of SHANK3, a PDZ domain …
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The Role of FAM21 in the Regulation of Mitochondrial Dynamics
… Family with sequence similarity 21 (FAM21), a retromer- and PI4P-binding protein of the nucleation-promoting factor Wiskott-Aldrich Syndrome protein family member WASH (WASH) complex, recruits WASH and Arp2/3 complexes to endosomal membranes. Coordinated activity of WASH and Arp2/3 complexes …
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Structural studies of SARS-CoV-2 spike protein and vesicular coats
… and its adaptor proteins, COPI, COPII and retromer. COPI facilitates transport within the Golgi apparatus, as well as from the Golgi towards the Endoplasmic Reticulum (ER). GOLPH3 is a Golgi resident protein acting as a gatekeeper at the late Golgi to retain other Golgi-residents. It is …
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DESIGN, SYNTHESIS AND BIOLOGICAL PROFILING OF NEW COMPOUNDS: INFECTIOUS AND NEURODEGENERATIVE DISEASES AS TARGETS
… the binding affinity of these compounds for the retromer complex at the critical Vps35-Vps29 interface, thereby bolstering their potential therapeutic efficacy. Concurrently, I rigorously pursued strategies to minimize off-target effects, particularly concerning interactions with the 5-HT …