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Showing 1 to 20 of 25 for “"retrograde transport"”.

  1. THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR IN RETROGRADE TRANSPORT ALONG MOTORNEURON AXONS

    Dangremond, Rebecca L2016

    … that skeletal muscle-BDNF is required for normal retrograde transport of proteins and mitochondria along gastrocnemius-associated motorneuron axons. We first measured accumulation of the retrogradely transported phosphorylated neurofilament-H (NF-H-P) protein at distal motorneuron axons in young …

    nmu Repository record

  2. THALAMIC PROJECTIONS TO MOTOR PREFRONTAL, AND SOMATOSENSORY CORTEX IN THE SHEEPSTUDIED BY MEANS OF THE HORSERADISH PEROXIDASE RETROGRADE TRANSPORT METHOD

    Dinopoulos, Athanasios, Ντινόπουλος, ΑθανάσιοςAristotle University Of Thessaloniki (AUTH)1984

    IN THIS STUDY THE MOTOR, PREFRONTAL AND SOMATOSENSORY AREAS OF THE SHEEP CEREBRAL CORTEX WERE DEFINED ON THE BASIS OF THEIR THALAMIC AFFERENTS TRACED WITH THE HORSERADISH PEROXIDASE METHOD. THE MOTOR AREA (AREAS 4 AND 6) OCCUPIES THE CRUCIATE GYRUS. IT RECEIVES A SUBSTANTIAL PROJECTION FROM THE …

    greece Repository record

  3. Functional Connection Between Yeast Dynamin and Retromer at the Endosome

    Trousdale, Christopher Robert

    … the late endosome to Golgi in cells is termed retrograde transport, essential for recycling of important macromolecules including cell membrane receptors. Retrograde transport is regulated by a family of proteins known as the "Retromer” composed of 5 VPS proteins (Vps5, Vps17, Vps26, Vps29, and …

    mo-state Repository record

  4. Quantitative Studies of Intracellular Trafficking of Two Classes of Resident Golgi Apparatus Proteins

    Starr, Tregei NicoleVirginia Tech2006

    … between the ER and Golgi at steady-state. Retrograde trafficking of these Golgi proteins has been demonstrated experimentally mandating the existence of a dynamic equilibrium between the Golgi apparatus and ER. Our published studies also included the development of a quantitative method for …

    vt Repository record

  5. CHARACTERIZATION OF THE ROLES OF MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR AND PRESYNAPTIC TYROSINE RECEPTOR KINASE B IN MOTOR NEURON AXONAL TRANSPORT

    VanOsdol, Luke A2019

    … more often, is delivered to the cell soma via retrograde axonal transport, where it modulates gene expression. BDNF activation of TrkB is critical for the initiation of axonal transport, and this cellular process relies on the interaction of numerous adaptor proteins, including dynactin and …

    nmu Repository record

  6. Lesion-induced Synaptic Remodelling In The Rat Red Nucleus

    Naus, Christian Cornelius1985

    … cortex were studied using anterograde and retrograde transport of horseradish peroxidase conjugated to wheat germ agglutinin (HRP-WGA), as well as retrograde transport of the fluorochromes Fast Blue and Nuclear Yellow. To examine the normal synaptology of the red nucleus, the anterogradely …

    uwo Repository record

  7. Regulation of peripheral nerve regeneration by the mTOR pathway

    Abe, Namiko2010

    … of injury signaling in the PNS, including the retrograde transport of local axonal injury signals, enhancement of axonal growth capacity in the cell body, and the response of Schwann cells that myelinate the damaged axon. We first addressed how axonal injury triggers enhancement of axonal …

    wustl Repository record

  8. Function of the forkhead gene fd3F in Drosophila chordotonal neuron differentiation

    Newton, Fay GabrielleThe University of Edinburgh2012

    … of the Ch neuron cilium and components of the retrograde transport machinery that may be required for protein localisation within the cilium. In addition several uncharacterised genes were identified as fd3F targets and these genes may therefore also be important for Ch neuron function. I have …

    edinburgh Repository record

  9. Understanding Neuronal Autophagic Lysosomal Pathways Through Genetic and Pharmacological Perturbations

    Amanda Snead (24400178)2026

    … despite its importance to axonal lysosome retrograde transport, the role of JIP3 in axonal transport of less mature autolysosomes and autophagosomes in mammalian neurons has not yet been described. Additionally, the impact of disrupting axonal lysosomal transport on neuronal autophagy has …

    uic

  10. Genetic analysis of dynein function in the nervous system and in mitosis

    Salvador Garcia, Jose DavidUniversity of Cambridge2020

    … adaptors and co-factors, dynein orchestrates retrograde transport of diverse cargoes in interphase cells and plays multiple roles in mitosis. The importance of this motor is underlined by the fact that mutations in Dynein heavy chain, the motor-containing subunit of dynein, cause neurological …

    cambridge Repository record

  11. Development of novel diagnostics and therapeutics for amyotrophic lateral sclerosis

    Townsend, Seth A. (Seth Alan)Massachusetts Institute of Technology2008

    … toxin C fragment (Gd-TTC) biomarker for axonal retrograde transport, 2) TTC-conjugated biodegradable nanoparticles, and 3) poly(glycerol-co-sebacate) acrylate (PGSA) and 3D scaffolds for human embryonic stem cell (hESC) and neuronal encapsulation.A Gd-TTC conjugate was developed and …

    mit Repository record

  12. THE EFFECT OF SKELETAL MUSCLE-SYNTHESIZED BDNF ON MOTOR NEURON SOMA SIZE AND BDNF PROTEIN ABUNDANCE

    Benson, Sydney2025

    … cascade that recruits dynein motor proteins for retrograde transport of the BDNF/TrkB endosome to the motor neuron soma. At the motor neuron soma, the BDNF/TrkB complex activates cyclic Adenosine Monophosphate (cAMP) response element binding protein (CREB), leading to transcriptional changes that …

    nmu Repository record

  13. "Molecular Analysis of Virulence Factors Unique to Leptopilina heterotoma-a Parasitic Wasp of Drosophila spp."

    Dziedzic, Noelle2018

    … interactions pointed to 9A08 functioning in retrograde transport and vacuolar protein sorting, leading us to hypothesize that 9A08 helps mediate endocytosis of VLPs in fly plasmatocytes. We will also discuss the precise endocytic retrograde trafficking routes that VLPs take before they are …

    cuny Repository record

  14. Mutational and functional analyses of the dynein heavy chain indicate the existence of an apical-sistal transport cycle in cells

    Sivagurunathan, SenthilkumarUniversity of Missouri--Kansas City2012

    … of eukaryotic cells depend on intracellular transport governed by the microtubule based molecular motors cytoplasmic dynein and kinesin. Dynein carries out the inward transport of cargos whereas kinesins are responsible for the outward movement. Although intracellular transport is necessary …

    umkc Repository record

  15. Developmental Dynamics of the Mouse Retinocollicular Projection: A Quantitative Characterisation

    Lyngholm, DanielKing's College London2012

    … This characterisation has been done by utilising retrograde transport of fluorescent microspheres administered by discrete injections into the SC and recovered from retinal flat-mounts. To enable quantification of topographic precision, retinae are standardised using an algorithm that permits …

    kings Repository record

  16. Charakterisierung eines Proteinkomplexes in Säugerzellen, der am Transport zwischen Membrankompartimenten beteiligt ist.

    Verrier, Sophie2012

    Intrazellulärer Transport vermittelt die Verteilung von Proteinen und Lipiden zwischen verschiedenen Kompartimenten. Dazu werden Vesikel vom Donorkompartiment abgeschnürt und zur Akzeptormembran transportiert, mit der sie fusionieren. Als zusätzlichen Weg betrachtet man den Transport in Form von …

    goettingen Repository record

  17. Involvement of a specific ubiquitin ligase in the assembly of the dynein motor in the filamentous fungus Neurospora crassa

    Elsenpeter, Ryan LeeUniversity of Missouri--Kansas City2012

    … motor proteins to accomplish intracellular transport. The two microtubule based motors, kinesin and cytoplasmic dynein, work in concert to move cargoes outward and inward, respectively, in the cell. In polarized cells, molecular motors are of even greater importance due to a need for long …

    umkc Repository record

  18. Investigating the neuroprotective role of carboxyl-terminus of Hsc70-interacting protein (CHIP) in healthy aging

    Poplawski, Janet2026

    … in CHIP-mediated processes including cellular transport, protein quality control, and longevity. SWATH-MS was performed on chn-1(by155) and chn-1(tm2692) deletion mutants, in addition to wild-type controls, processed by either SDS or CHAPS/urea-based lysis protocols. Between-buffer analyses …

    edinburgh Repository record

  19. The function of golgin vesicle tethers in Drosophila melanogaster

    Park, Sung YunUniversity of Cambridge2020

    … TMF, Golgin-84, and GMAP tether Golgi-derived retrograde transport carriers. Furthermore, ultrastructural data evidence the function of these golgins as bona fide vesicle tethers in Drosophila tissues. More importantly, adding a tissue-specific dimension to the relocation assay elicited novel …

    cambridge Repository record

  20. Steps to Reconstitute in vitro a Complete Round of COPI vesicle Budding, Uncoating and Fusion

    Jawhari, HatimUniversität Heidelberg

    … COPI coated vesicles), COPI vesicles mediate the transport in both anterograde and retrograde transport within the Golgi complex (Orci et al., 1997) as well as recycling of proteins from the Golgi to the ER (Cosson and Letourneur, 1994; Letourneur et al., 1994). An in vitro based assay using …

    heid-diss Repository record

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