Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"retrograde trafficking"”.
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Cellular interactions of the cytolethal distending toxins
… in molecular details. Utilizing host uptake and trafficking system, pathogenic effector proteins, called toxins, have exploited existing pathways as a mean to access intracellular targets and modulate host cellular functions. Among known targets in the human host, nucleus has been an infrequent, …
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Identification of novel biomarkers and therapeutic strategies in triple negative breast cancer
… complex which forms vesicles responsible for retrograde trafficking of cellular proteins from the Golgi to the endoplasmic reticulum (ER) as well as regulating autophagy and endosome maturation. COPZ1 silencing induces ER stress and cell death in multiple TNBC cell lines while having no effect …
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Syntaxin 6- and Microtubule- Mediated Intracellular Trafficking Contributes to Golgi and Nuclear Translocation of Egfr
… is well known for its degradation and recycling trafficking. Recent evidence shows that these cell surface receptors translocate from cell surface to different cellular compartments, including the Golgi, mitochondria, endoplasmic reticulum (ER), and the nucleus to regulate physiological and …
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Quantitative Studies of Intracellular Trafficking of Two Classes of Resident Golgi Apparatus Proteins
… between the ER and Golgi at steady-state. Retrograde trafficking of these Golgi proteins has been demonstrated experimentally mandating the existence of a dynamic equilibrium between the Golgi apparatus and ER. Our published studies also included the development of a quantitative method for …
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"Molecular Analysis of Virulence Factors Unique to Leptopilina heterotoma-a Parasitic Wasp of Drosophila spp."
… the contributions of VLP proteins in VLP trafficking within host cells, we took advantage of proteomic data from purified Lh VLPs. Two novel enzymes encoded by venom gland cDNA clones 9A08 and 2E04 were identified. To understand how 9A08 exerts virulence, an unbiased and comprehensive …
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Identification and characterization of components of rab-6-mediated trafficking in caenorhabditus elegans
Membrane trafficking in neurons is an important mechanism used to regulate signaling. Controlling the abundance of AMPA-type receptors at the synapse is important for synaptic plasticity and influences processes involved in learning, memory formation, and motor control (Greger and Esteban, 2007; …
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Role of diacylglycerol in the cellular response to lysophosphatidylcholine analogues
… genetic array analysis pointed to endocytic and retrograde trafficking proteins as key players in modulating DAG distribution. Many of these trafficking mutants were also resistant to edelfosine, suggesting mislocalization of DAG is advantageous in the presence of edelfosine. In addition, a …
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Engineering of the RTB Lectin as a Carrier Platform for Proteins and Antigens
… role due to its well-characterized endocytotic trafficking and its efficacy over a wide range of cell types. By producing RTB recombinantly in plants it is possible to create a fully active, non-toxic carrier that does not rely on the processing of large amounts of toxic material (e.g. castor …