Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"retroactivity"”.
-
Retroactivity, modularity, and insulation in synthetic biology circuits
… upon interconnections, a phenomenon called retroactivity. Addition of a new component to a system can change individual device dynamics within the system, potentially making timeconsuming iterative redesign necessary. Another need for systems construction is the ability to rapidly assemble …
-
Phosphorylation based insulation devices design and implementation
… cerevisae and the minimization of the retroactivity to the input and retroactivity to the output of a single cycle phosphorylation device by means of optimal substrate and phosphatase concentration selection. Characterizing and improving the performance of insulation devices brings us a …
-
Modularity of signaling cycle architectures
… the ability to attenuate the effect of retroactivity applied by downstream systems and hence facilitate modular design in synthetic biology. Phosphorylation cycles are ubiquitous in cell signal-transduction systems. Single phosphorylation cycles have been found to have insulating …
-
Fundamental limitations between noise and back-action in bio-molecular networks
… the back-effect to the upstream system, called 'retroactivity', thereby increasing the perturbation to the upstream system. In this thesis, we seek to quantify the total error in the system caused by the perturbations due to retroactivity and noise, and to analyze the trade-off between the two …
-
RNA-based portable genetic circuits and synthetic plasmids
… an RNA compensation strategy to mitigate the retroactivity generated by the interconnection of multiple modules in RNA-based circuits. The insulation strategy is computationally proven to be effective not only in static modules but also in dynamic RNA-based circuits. Lastly, we develop …
-
A critical analysis of the legality of retroactive fiscal legislation and the remedies available to taxpayers
… completed transactions, the presumption against retroactivity will provide an effective remedy to taxpayers should the retroactive legislation not explicitly provide that it will apply to completed transactions. Under statute law, the treatment of statues which are subject to commencement …
-
Functional modularity in gene networks
… in both systems and synthetic biology: retroactivity and competition for shared cellular resources. The contribution is the development of simple-to-use computational tools that aide the analysis and design of multi-module genetic systems. These tools are a result of combining …
-
Loading as a design parameter for genetic circuits
… system's performance. In this thesis, we study retroactivity, a specific type of context-dependence, by analyzing the effects of loads on a transcription factor applied by the transcription factor's target sites. In particular, we study this loading effect on the model of an activator-repressor …
-
Principles for the design and construction of synthetic circuits utilizing protein-protein interactions in Saccharomyces cerevisiae
… transcriptional regulatory modules to mitigate retroactivity, exemplifying time-scale separation as a means of realizing functional modularity in biological networks. The second system, a fast bistable toggle switch, is the first synthetic network based solely on protein interactions and can be …
-
The implementation of the universal jurisdiction over torture in European countries
… solved, especially those relating to the non-retroactivity of the implemented legislation, the prohibition of amnesties, as well as the legality of the proceedings in the absence of the offender and of the operation of a principle of subsidiarity. The latter principle would give primacy …
-
Co-Design of Resource Limited Genetic Networks Tuning System Parameters to Satisfy Specifications
… in biological systems, such as load effects (retroactivity), unknown interactions and resource competition, which is our focus for this work. Recent efforts to achieve modular design in systems with resource competition, have focused in adding additional machinery to the cell to either try to …
-
The role of imagined interaction and self-efficacay in psychosocial adjustment to spousal bereavement: a communication perspective
… discrepancy, activity, proactivity, specificity, retroactivity, variety, valence, catharsis, self-understanding, rehearsal, compensation and use of IIs with the deceased spouse. The current study's primary contribution is the introduction of bereavement phenomena into the framework of …
-
Independent Internationalism and Nationalistic Pragmatism: The United States and Mexico Relations during the 1920s
… and the Mexican Congress invalidated the retroactivity of such laws. A second point of contention was the Church-State controversy in México. American Catholics demanded direct U.S. intervention, but Coolidge instructed Morrow to work with representatives of the Catholic Church and the …
-
Independent Internationalism and Nationalistic Pragmatism: The United States and Mexico Relations during the 1920s
… and the Mexican Congress invalidated the retroactivity of such laws. A second point of contention was the Church-State controversy in México. American Catholics demanded direct U.S. intervention, but Coolidge instructed Morrow to work with representatives of the Catholic Church and the …
-
Zur Umsetzung von EG-Richtlinien und staatengerichteten EG-Entscheidungen in deutsches Recht und Überprüfung der Umsetzung der Fleischhygienegebührenrechtsakte der EG
Das nationale Recht wird mehr und mehr durch EG-Recht beeinflussst. In diesem Zusammenhang ergeben sich bei denjenigen EG-Rechtsakten, die anders als EG-Verordnungen nicht unmittelbar in den Mitgliedstaaten gelten, sondern von diesen in nationales Recht umgesetzt werden müssen, vielfältige …