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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"retinoids"”.
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Synthetic Retinoids
… providing general overviews of synthetic retinoids and their biology, Pd-catalysed C-C bond forming reactions and transition metal-catalysed borylation of aromatic and vinylic C-H bonds, respectively. Chapter two details the application of sequential Ir-catalysed aromatic C-H borylations, …
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Interaction between retinoids and methyl group metabolism
… doses (30 [mu]mol/kg BW) of various retinoids administered daily for a total of 10 d. Here, we examined the dose- and time-dependent relationship between all-trans-retinoic acid (ATRA) administration and induction of GNMT, as well as determining additional indices of methyl group and …
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The Biological Effects of Novel Synthetic Retinoids
Naturally occurring Retinoids are known to play a role in many developmental processes in the early embryo as well as being a potent tool for in vitro differentiation of stem cells. The exogenous application of these naturally occurring retinoids as well as some of their synthetic analogs has been …
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The Effects of Retinoids on Regenerating Axolotl Limbs
… value. Recently, vitamin A and its derivatives (retinoids) have been found to proximalize positional value, causing duplication of stump structures in the regenerate. Positional values along the proximodistal (PD) axis are associated with a gradient of cell surface adhesivity, and retinoids have …
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Synthesis and Biological Investigation into the Metabolism of Retinoids
Retinoids have a wide variety of applications. They can act as potent inducers of stem cell differentiation, as chemopreventative and chemotherapeutic agents, and have been utilised for the treatment of dermatological conditions. However, natural retinoids readily undergo photo-isomerisation in the …
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The role of retinoids in the regeneration of the axolotl spinal cord
Retinoids play an important role in tissue patterning during development as well as in epithelial formation and health. In the mammalian central nervous system, the meninges are a source of retinoids for brain tissue. Retinoid production has been described in juvenile Axolotl ependymal cells. …
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Patterning of the posterior neurectoderm by labial-like Hox genes and retinoids
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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THE EFFECTS OF RETINOIC ACID ON CELLULAR TRANSFORMATION AND TUMORIGENESIS INVOLVING CELLS WITH KNOWN ONCOGENES (VITAMIN A, RETINOIDS, RETROVIRUS)
Vitamin A is known to have an important role in cellular differentiation and proliferation. In addition to regulating normal cellular processes vitamin A has also been shown to possess potent antineoplastic activity. The work in this dissertation characterizes the role of retinoic acid (RA) in …
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"The use of retinoids and an in vivo ""affinophoresis"" assay to analyze the cellular basis of positional memory in regenerating axolotl limbs"
… from more proximal limb stumps. Recently, retinoids (vitamin A and its derivatives) have been shown to predictably modify positional memory in regenerating amphibian limbs resulting in PD duplications of stump structures within the regenerate. This discovery creates a means by which the …
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Molecular Mechanisms of Growth Inhibition Mediated by Retinoic Acid in Human Pancreatic Cancer Cells
… survival rate after treatment in less than 2%. Retinoids are differentiating agents, that have the potential to inhibit the proliferative capacity of cancer cells as well as induce morphological and biochemical changes. They can induce cancer cells to redifferentiate. Therefore, retinoids offer …
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Retinoic Acid and the Underlying Cellular Mechanisms involved in Neurite Outgrowth and Growth Cone Turning during Regeneration
… turning was induced by endogenous or synthetic retinoids, and also whether the growth cones were still attached to the cell body or not. Overall, these data provide new insights into the mechanisms by which retinoids affect neurite outgrowth and growth cone behaviour during regeneration of the …
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Carotenoid metabolism in mice and prostate cancer risk
… results in formation of retinoic acid and other retinoids. The metabolism of β-carotene has been extensively studied, but very little is known about the metabolism of other carotenoids. We and others have hypothesized that other acyclic carotenoids, like lycopene, are eccentrically cleaved by …
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Physiology and Pathophysiology of Retinoid and Lipid Storage in Mouse Hepatic Stellate Cell Lipid Droplets
Retinoids are important mediators of many physiological processes in the body, including vision, reproduction, embryonic development, immunity and bone growth. Thus, the storage and metabolism of retinoids in the body has immediate implications for the overall health and metabolic homeostasis of …
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Genotype effects impact lipids and organ weights in female mice lacking carotenoid cleavage enzymes
… (CMO-I), to eventually form biologically-active retinoids. Lycopene is a non-provitamin A carotenoid and the most abundant carotenoid in tomatoes. Lycopene is a poor substrate for CMO-I, but our lab along with other has proposed that the enzyme carotenoid 9'10'-monoxygenase (CMO-II) can …
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Defining risk for metabolic syndrome in young Mexican adults: the relationship between β,β-carotene-15,15'- oxygenase 1, nutrition and the lipid profile
… Vitamin A and carotenoids are one such target. Retinoids are key in facilitating many physiological functions from cell differentiation and embryogenesis to vision and lipid metabolism (5). Vitamin A and carotenoids are compounds that demonstrate the activity of retinoids and have shown …
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Evaluation of the role of autophagy in acute myeloid leukaemic cell differentiation
… I explore the molecular communication between retinoids and autophagy and study the expression changes in autophagy-related genes occurring in ATRAtreated APL cells. I also demonstrate that ISGylation is activated during differentiation, a process regulating the addition of a ubiquitin-like …
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The Role of Retinoic Acid in the Formation and Modulation of Invertebrate Electrical Synapses
… provide novel insights into the role that retinoids play in the both the formation and modulation of electrical synapses in the CNS.
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Synthesis and Characterization of Bexarotene Derivatives with Potential Biological Activity // Получаване и охарактеризиране на бексаротенови производни с потенциална биологична активност
… The continued and intensive study of the role of retinoids in the complex of differentiation, cell proliferation, and cellular growth processes determines the major potential for the using of retinoids (natural and synthetic) in the treatment of a number of abnormalities arising from abnormal cell …
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