Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"retinoid"”.
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Roles in Retinoid Signaling in the Lower Urinary Tract
Retinoic acid (RA)-signaling is involved in a broad spectrum of cellular processes, including formation of most embryonic tissues, epithelial differentiation, and is a critical regulator of stem cell differentiation in vitro. Studies from our lab have focused on the role of RA-signaling in the …
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Strategies of overexpressing retinoid X receptor and pregnane x receptor for functional studies
<p>The ligand activated transcription factor retinoid X receptor (RXR) forms a DNA binding heterodimer with pregnane X rseceptor (PXR) in response to foreign xenobiotics. In addition to RXR and PXR there are other proteins involved in the RXR/PXR signaling pathway. Many proteins involved in this …
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Physiology and Pathophysiology of Retinoid and Lipid Storage in Mouse Hepatic Stellate Cell Lipid Droplets
Retinoids are important mediators of many physiological processes in the body, including vision, reproduction, embryonic development, immunity and bone growth. Thus, the storage and metabolism of retinoids in the body has immediate implications for the overall health and metabolic homeostasis of …
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Retinoid X Receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination
… we show that expression of genes involved in the retinoid X receptor (RXR) and peroxisome proliferator-activated receptor (PPAR) pathways are decreased with ageing in both myelin-phagocytosing human monocytes and mouse macrophages. Disruption of RXR and PPAR using synthetic antagonists in young …
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Elucidation of the Retinoid Signalling Pathway Involved in Axon Guidance in Lymnaea stagnalis and Xenopus laevis
… receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), to mediate gene transcription. Moreover, RA has been shown to act as a guidance molecule for growth cones of regenerating motorneurons of the pond snail, Lymnaea stagnalis. Our lab has recently shown that RA can induce …
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Retinoid X Receptor as a Mediator of Post Stroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Macrophages
… resulting in poor recovery after stroke. Retinoid-X-receptor (RXR) is a pleiotropic transcription factor. Our studies suggest that RXRa enhances MF phagocytic functions, reduces inflammatory responses, and improves post-stroke recovery. To establish phenotypes of aging MF, MG were …
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The Biological Effects of Novel Synthetic Retinoids
Naturally occurring Retinoids are known to play a role in many developmental processes in the early embryo as well as being a potent tool for in vitro differentiation of stem cells. The exogenous application of these naturally occurring retinoids as well as some of their synthetic analogs has been …
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The role of retinoids in the regeneration of the axolotl spinal cord
Retinoids play an important role in tissue patterning during development as well as in epithelial formation and health. In the mammalian central nervous system, the meninges are a source of retinoids for brain tissue. Retinoid production has been described in juvenile Axolotl ependymal cells. …
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Retinoic Acid and the Underlying Cellular Mechanisms involved in Neurite Outgrowth and Growth Cone Turning during Regeneration
… on cultured neurons. I demonstrated that various retinoid receptor agonists could mimic the chemotropic effects of RA, providing further evidence for a potential role of retinoid X receptor and retinoic acid receptors in growth cone turning. I also examined potential downstream effectors involved …
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Biomarkers identification in fibromyalgia syndrome
… compared with healthy controls. TTR and RBP4 are retinoid transporters, moreover retinoid dysfunction is related to oxidative stress as well as A1AT. These results support the hypothesis that oxidative stress could be implicated in the pathophysiology of FMS. Moreover, considerably higher serum …
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Comparative Plasma Proteomics in Muscle Atrophy Induced by Cancer Cachexia and Hindlimb Unloading
… response signaling system and liver X receptor/retinoid X receptor (LXR/RXR) and farnesoid X receptor/retinoid X receptor (FXR/RXR) activation. Conclusion: Plasma proteomic profiles are altered in cancer cachexia and disuse-induced atrophy. Modulated protein profiles suggest the possibility of …
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Synthesis and Biological Investigation into the Metabolism of Retinoids
Retinoids have a wide variety of applications. They can act as potent inducers of stem cell differentiation, as chemopreventative and chemotherapeutic agents, and have been utilised for the treatment of dermatological conditions. However, natural retinoids readily undergo photo-isomerisation in the …
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Re-examining the relationships among families of Pectinoidea and molecular machinery of the visual cycle in molluscs
… to expand on the current hypothesis of the retinoid visual cycle in molluscs. The search results were then divided by protein family and used to develop protein phylogenies with vertebrate and insect anchor sequences to suggest putative homology of function of molluscan blast results. From …
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Magreceptorok ligandkötési affinitásának vizsgálata FRET szenzorral
… az emberi retinsav alfa receptor (RAR) és retinoid x receptor (RXR) magreceptorok ligandkötési affinitását vizsgáltam a ligandkötő doménjük (LBD) konformációváltozása révén. Olyan DNS konstruktokat (plazmidokat) kellett létrehoznom, amelyekben a receptorok ligandkötő doménje fluoreszcens …
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Surface Functionalised Emulsion- Templated Porous Polymers for In- Vitro Cell Culture
… to the surface of the PolyHIPE with synthetic retinoid EC23 has been proposed, and initial chemical tests obtained to suggest attachment, with future testing with mammalian cells envisaged.
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Dietary tomato carotenoids and β-carotene-15,15'- dioxygenase (Bco1) genotype alter androgen metabolism, lipid metabolism, and prostate cancer progression in mice
… the impact of Bco1 on lipid, cholesterol, and retinoid metabolism in the liver, a key organ in the metabolism and biodistribution of dietary carotenoids; and evaluate the effects of dietary tomato feeding in an animal model of PCa and determine its efficacy in preventing disease progression. In …
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The Role of Retinoic Acid in the Formation and Modulation of Invertebrate Electrical Synapses
… acute effect might be independent of either the retinoid receptors or a protein kinase. In addition, I provide novel findings to suggest retinoic acid is also capable of regulating the formation of electrical synapses. Long term exposure to two isomers of retinoic acid, all-trans-retinoic acid …
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Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes
… with synthetic agonists of liver X receptor and retinoid X receptor in a similar manner. In addition, ATP-binding cassette transporter a1 transcription, LXR-induced target gene, was increased by addition of either oxysterol or LXR agonist. Thus, I conclude that these effects are mediated by …
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