Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"retinoic acid-inducible gene-I (RIG-I)"”.
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
… is critical to drive development of next generation therapies. We demonstrate that cancer cells co-opt anti-viral signaling to sustain genetic programs that drive resistance to multiple anti-cancer modalities. In the context of radiation resistance, upon heterotypic interaction, exosomes …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
… of interferon (IFN) and IFN-stimulated genes required for viral clearance and the generation of a HCV-specific adaptive immune response. Upstream signaling components of IRF-3 were unknown, therefore, the NS3/4A protease was utilized as a tool to elucidate putative upstream signaling …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
… of interferon (IFN) and IFN-stimulated genes required for viral clearance and the generation of a HCV-specific adaptive immune response. Upstream signaling components of IRF-3 were unknown, therefore, the NS3/4A protease was utilized as a tool to elucidate putative upstream signaling …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
… persistent hepatic inflammation can lead to degenerative liver disease, this work sought to evaluate how innate immune sensors of HCV infection (Toll-like receptor 3 [TLR3] and retinoic acid inducible gene I [RIG-I]) contribute to CXCL10 induction in hepatocytes. CXCL10 mRNA and protein were …
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Understanding Host Antiviral Signaling Pathways
… systems that detect virally-derived nucleic acids and trigger signaling pathways which lead to the activation of transcription factors like nuclear factor-kappa B (NF-kappa B), interferon regulatory factor 3 (IRF3) and interferon regulatory factor 7 (IRF7). These transcription factors …
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Hepatitis C Virus NS3/4A Protease and the Intracellular Antiviral Response: Mapping Complex Virus-Host Interactions
Virus infection triggers an innate immune response characterized by host cell production of interferon (IFN). Intermediates of viral replication, including dsRNA, initiate a signaling cascade that is amplified within the cell and alerts neighboring cells of viral invaders. Recognition of dsRNA …
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Host cell signaling in response to RSV infection
… to this field.\r\nFirstly, I found that retinoic acid-inducible gene I (RIG-I) and Toll like receptor 3 (TLR3) play distinct roles in mediating RSV-induced innate immune responses. Short interfering RNA (siRNA)-mediated RIG-I \"knockdown\" significantly inhibited the translocation of …
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Investigating the mechanisms behind the immunostimulatory activity of influenza A virus RNA polymerase mutations
… IAV infections are primarily detected by the retinoic acid-inducible gene I (RIG-I), which recognises the partially double-stranded, 5′-triphosphorylated RNA structure that is formed by the protein-free 3′ and 5′ termini (viral promoter) of viral genomic segments as well as aberrant …
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Cellular responses to external threats probed by super-resolution microscopy
… systems. Viral infection in mammalian cells triggers the immune response, a cascade of antiviral signaling proteins. For double stranded RNA (dsRNA) virus, the innate immune response starts from retinoic acid-inducible gene-I (RIG-I) protein which is a dsRNA sensor. For certain types of …