Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"retinoic acid receptors"”.
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The roles of the retinoic acid receptors in growth, differentiation and development.
… of this thesis I have looked at the roles of the retinoic acid receptors (RARs) in differentiation by assessing their actions in the retinoic acid (RA) induced differentiation of P19 cells. I used mutant RARs to block the normal differentiation of these cells and then analyzed the possible …
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Inhibition of Retinoic Acid Receptors Results in Defasciculation of the Trigeminal Nerve in Xenopus laevis
… syndrome. We have discovered that retinoic acid (RA) may play a role in the development of the trigeminal nerve. Inhibition of retinoic acid receptors (RAR) results in trigeminal nerves that become unbundled or defasciculated in the eye region. To further understand how RA is …
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Strategic modification of oligonucleotides with carboxylic acids containing small molecules
… specificity and stability of the RNA. Carboxylic acids such as folic and retinoic acid have been used extensively in RNA disease and cancer research due to their strong binding affinities to folate and retinoic acid receptors in the body. This has allowed us to tag various carboxylic acids …
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Retinoic Acid Regulation of Thyroid Hormone Action in Bone Cells
<p>Retinoic acid and thyroid hormone are known to play key roles in the regulation of endochondral ossification. However, the issue of whether these two hormones interact with each other to regulate bone functions remains to be established. We investigated how thyroid hormone and retinoic acid …
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The Effect of HACE1 on RAR Protein Stability
All-trans retinoic acid (RA), as a ligand for retinoic acid receptors (RAR) and retinoid X receptors (RXR), modulates their transcriptional activity. The AF-1 and AF-2 domains mediate the transcriptional activity. The ligand dependent activation of the AF-2 domain by RA is well understood to …
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Retinoic Acid and the Underlying Cellular Mechanisms involved in Neurite Outgrowth and Growth Cone Turning during Regeneration
The involvement of retinoic acid (RA) in nervous system regeneration has been well documented, though the precise cellular and molecular mechanisms have not yet been fully determined. During regeneration, RA can exert trophic support for cells, as well as tropic effects to guide neurite outgrowth. …
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Identification and characterization of retinoic acid-induced morphological and electrophysiological changes in an invertebrate nervous system
The vitamin A metabolite, retinoic acid (RA) is known to play an important role in the development, patterning and regeneration of nervous tissue, both in the embryo and in the adult. Classically, RA is known to mediate the transcription of target genes through the binding and activation ofits …
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The role of retinoic acid in glioma growth control
… cells using a differentiation agent such as retinoic acid (RA) could be a promising scientific advance in the treatment of this disease. Endogenous retinoic acid is the primary active metabolite of vitamin A. It is a small, lipophilic differentiation agent that acts as a ligand for a family …