Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"retinoic acid receptor"”.
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Regulation of Intestinal Epithelial Thymic Stromal Lymphopoietin Gene Expression by Retinoic Acid Receptor Alpha
… to environmental exposures. Dietary factors like retinoic acid (RA), a vitamin A metabolite, have been linked to the onset of IBD by influencing intestinal immune function. RA induces Tregs and inhibits the actions of proinflammatory Th-17 cells. We have previously described decreased CD103+ DCs …
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Differentially expressed genes in oesophageal cancer : Retinoic acid receptor-ß2, Trio and Abl-related gene
Bibliography: leaves 95-104.
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Epithelial Retinoic Acid Receptor Beta Regulates Serum Amyloid A Expression and Vitamin A-Dependent Intestinal Immunity
… to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium, yet little is known about how epithelial cells regulate vitamin A-dependent intestinal immunity. Here I show that epithelial cell expression of the transcription factor retinoic acid receptor β (RARβ) is …
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The Effect of Retinoic Acid on Rai1 and Identification of Retinoic Acid Receptor Binding Site in Human Rai1
… gene expression in zebrafish is regulated by retinoic acid. Treatment with retinoic acid increases the expression of rai1. In this study, we focused on the effect of retinoic acid on human RAI1 expression. We found the expression of RAI1 was enhanced by the treatment with retinoic acid. The …
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Molecular Dynamics Study of Hormone Receptors Binding DNA and Hormones
… of modified DNA, binding of the estrogen receptor to specific and non-specific DNA, and binding/unbinding of hormones to/from retinoic acid receptor and thyroid hormone receptor. In the DNA dodecamer, d(CGCGAATTCGCG), two Adenine residues, individually or jointly, were replaced with the 2 …
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Role of Abberant Proteolysis in the Pathogenesis of APL
… the promyelocytic leukemia (PML) and the retinoic acid receptor N1 (RARN1) genes. PML-RARN1 promotes misfolding of nuclear hormone receptor corepressor (N-CoR) and that accumulation of misfolded N-CoR in the ER induces endoplasmic reticulum (ER) stress and activates unfolded protein …
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Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity
… We hypothesized that BMS 493, an inverse retinoic acid receptor agonist, will prevent HSPC differentiation of HSPC during expansion, generating more ALDHhi cells for therapy. ALDHhi cells expanded for 6 days with BMS 493 showed a 2.70-fold-increase in ALDHhi cells compared to untreated …
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ROLE OF THE HISTONE DEMETHYLASE LSD1 IN THE REGULATION OF DIFFERENTIATION OF ACUTE PROMYELOCYTIC LEUKEMIA CELLS
… of blasts, insensitive to physiological retinoic acid (RA)-dependent differentiation and in the majority of the cases, expressing PML-RAR fusion protein. PML-RAR works as a dominant negative counterpart of retinoic acid receptor (RAR) and represses its target genes by cooperating with …
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Regulation of NF-κB by PML and PML-RARα
… leading to the expression of a PML-retinoic acid receptor-α (PML/RARα) fusion protein are causative for acute promyelocytic leukemia (APL). We demonstrate that sumoylation of PML and PML NBs isinvovled in NF-κB- induced transcriptional responses and is required for phosphorylation of …
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Translating biomedical research data to knowledge through bioinformatics
… conditions, we concluded that the pathways of retinoic acid receptor activation, eukaryotic initiation factor 2 signaling, and protein ubiquitination play significant roles in addictive behavior and thus direct our focus on individual differences in susceptibility to addiction. Second, through …
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Elucidation of the Retinoid Signalling Pathway Involved in Axon Guidance in Lymnaea stagnalis and Xenopus laevis
The vitamin A metabolite, retinoic acid (RA), is known to play a crucial role in several developmental processes including axial patterning and differentiation. More recently, RA has been implicated in the regenerative process acting through its classical signaling pathway, the nuclear receptors, …
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The role of retinoic acid in glioma growth control
… cells using a differentiation agent such as retinoic acid (RA) could be a promising scientific advance in the treatment of this disease. Endogenous retinoic acid is the primary active metabolite of vitamin A. It is a small, lipophilic differentiation agent that acts as a ligand for a family …
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The Role of Notch Signaling in the Pathogenesis of Acute Promyelocytic Leukemia
… the promyelocytic leukemia: PML) gene with the retinoic acid receptor alpha: RARA) gene. The fusion product, PML-RARA, encodes a functionally altered transcription factor that is the initiating event in APL. To better understand the transcriptional changes associated with APL pathogenesis, we …
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Molecular changes involved in oral cancer progression and their relevance to keratinocyte immortalisation
… this is associated with loss of expression of retinoic acid receptor (RAR)-b and the cell cycle inhibitor, p16INK4a, p53 mutations and increased levels of telomerase/hTERT mRNA. In contrast, increased expression of the EGF receptor (EGF-R), known to be a characteristic of oral cancer, does not …
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Steered molecular dynamics: a tool to investigate molecular interactions
… of unbinding pathways, the contribution of amino acid residues and water molecules to adhesion, as well as the spatial range over which avidin binds biotin. No particular scaling of the maximum applied force with the loading rate was observed. (2) Movement of one of the domains of the …
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The Effect of HACE1 on RAR Protein Stability
All-trans retinoic acid (RA), as a ligand for retinoic acid receptors (RAR) and retinoid X receptors (RXR), modulates their transcriptional activity. The AF-1 and AF-2 domains mediate the transcriptional activity. The ligand dependent activation of the AF-2 domain by RA is well understood to …