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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 187 for “"retinoic acid"”.
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The Effect of Retinoic Acid on Rai1 and Identification of Retinoic Acid Receptor Binding Site in Human Rai1
… gene expression in zebrafish is regulated by retinoic acid. Treatment with retinoic acid increases the expression of rai1. In this study, we focused on the effect of retinoic acid on human RAI1 expression. We found the expression of RAI1 was enhanced by the treatment with retinoic acid. The …
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The role of retinoic acid in glioma growth control
… cells using a differentiation agent such as retinoic acid (RA) could be a promising scientific advance in the treatment of this disease. Endogenous retinoic acid is the primary active metabolite of vitamin A. It is a small, lipophilic differentiation agent that acts as a ligand for a family …
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Retinoic Acid Regulation of Thyroid Hormone Action in Bone Cells
<p>Retinoic acid and thyroid hormone are known to play key roles in the regulation of endochondral ossification. However, the issue of whether these two hormones interact with each other to regulate bone functions remains to be established. We investigated how thyroid hormone and retinoic acid …
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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation To Promote Immune Suppression
… that the TME induced tumor cells to produce retinoic acid (RA), which polarized intratumoral monocyte differentiation towards TAMs and away from DCs via suppression of DC-promoting transcription factor Irf4. Genetic inhibition of RA production by tumor cells or pharmacologic inhibition of RA …
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The roles of the retinoic acid receptors in growth, differentiation and development.
… of this thesis I have looked at the roles of the retinoic acid receptors (RARs) in differentiation by assessing their actions in the retinoic acid (RA) induced differentiation of P19 cells. I used mutant RARs to block the normal differentiation of these cells and then analyzed the possible …
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The Interactions for the RBP Receptor, Stimulated by Retinoic Acid Gene 6
… was recently identified as stimulated by retinoic acid gene 6 (STRA6), a 74 kDa multitransmembrane protein with no similarity to any other protein receptor. At present, receptor function, architecture and structure-function relationships remain relatively unexplored. Identification of any …
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Establishment of retinoic acid gradients in the early development of Xenopus laevis
Retinsäure (RA) ist ein wichtiges Morphogen, das viele biologische Prozesse reguliert, einschließlich der Entwicklung des zentralen Nervensystems (ZNS). Die Synthese von RA aus Vitamin A (Retinol) läuft in zwei Schritten ab, wobei die zweite Reaktion- katalysiert von Retinal-Dehydrogenasen …
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Effects of retinoic acid on ribosomal RNA gene expression during limb regeneration
… RNA was isolated from blastemas of control and retinoic acid (RA) treated animals during the following limb regeneration stages: initial dedifferentiation (ID), medium bud (MB), notch (N), and 3-finger bud (3-FB). Xenopus nuclear rDNA and axolotl 16S mitochondrial rDNA fragments were used to …
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The Role of Differential Sensitivity to Retinoic Acid (RA) in Regulating Spermatogonial Fate
… prior to differentiating in response to retinoic acid (RA) and later entering meiosis. The mechanisms regulating spermatogonial response to RA are undefined, and their identification would represent a key advance in our understanding of how spermatogonial fate is determined both at the …
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The role of retinoic acid in germ cell development in embryonic mouse gonads
… gonad explant culture experiments, I show that retinoic acid (RA) is required for meiotic initiation in embryonic ovaries, because it is necessary for Stra8 (Stimulated by retinoic acid gene 8) expression. Stra8 is required for pre-meiotic DNA replication in embryonic ovaries and it is only …
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Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity
… We hypothesized that BMS 493, an inverse retinoic acid receptor agonist, will prevent HSPC differentiation of HSPC during expansion, generating more ALDHhi cells for therapy. ALDHhi cells expanded for 6 days with BMS 493 showed a 2.70-fold-increase in ALDHhi cells compared to untreated …
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Molecular Mechanisms of Growth Inhibition Mediated by Retinoic Acid in Human Pancreatic Cancer Cells
… results have also been obtained with 9-cis- retinoic acid in combination with tamoxifen in Phase I trials in breast cancer. Retinoic acid has also been successful in the treatment of several other malignancies. Clinical trials with 13-cis retinoic acid in combination with interferon-a in …
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Regulation of Intestinal Epithelial Thymic Stromal Lymphopoietin Gene Expression by Retinoic Acid Receptor Alpha
… to environmental exposures. Dietary factors like retinoic acid (RA), a vitamin A metabolite, have been linked to the onset of IBD by influencing intestinal immune function. RA induces Tregs and inhibits the actions of proinflammatory Th-17 cells. We have previously described decreased CD103+ DCs …
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The Role of Retinoic Acid in the Formation and Modulation of Invertebrate Electrical Synapses
… of electrical synapses are poorly understood. Retinoic acid, a vitamin A metabolite, is a known regulator of chemical synapses, yet its capacity to regulate electrical synapses is not as well established. Preliminary evidence from the central neurons of both invertebrates and vertebrates …
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Glycolipids in mouse F9 teratocarcinoma cells: some changes associated with retinoic acid-induced differentiation
… to differentiate in vitro in the presence of retinoic acid. Control embryonal carcinoma cells and their differentiated derivatives, RNF9 cells, were metabolically-radiolabeled with [6-3H]galactose or [6-3H]glucosamine, and their glycolipids were compared. The neutral and acidic glycolipid …
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Inhibition of Retinoic Acid Receptors Results in Defasciculation of the Trigeminal Nerve in Xenopus laevis
… syndrome. We have discovered that retinoic acid (RA) may play a role in the development of the trigeminal nerve. Inhibition of retinoic acid receptors (RAR) results in trigeminal nerves that become unbundled or defasciculated in the eye region. To further understand how RA is …
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Regulation of the Insulin-like Growth Factor System by Retinoic Acid in Human Osteoblast Cells
<p>Retinoic acid (RA) is an important regulator of growth and differentiation in many cell types, including bone. However, its effects on human osteoblast cell growth and differentiation have not been well studied. Therefore, I investigated the effect of RA on proliferation and differentiation of …
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Differentially expressed genes in oesophageal cancer : Retinoic acid receptor-ß2, Trio and Abl-related gene
Bibliography: leaves 95-104.
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