Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"retinoblastoma binding protein"”.
-
A yeast 2-hybrid screen to identify and characterize interaction partners of the cancer associated protein retinoblastoma binding protein 6
Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa protein that is implicated in mRNA processing and ubiquitination functions and has been shown to be highly up-regulated in a number of cancers. In humans and mice,RBBP6 interacts with both tumour suppressors p53 and pRb, suggesting that it is …
-
Biophysical investigations of the interaction between substrate binding domain of Hsp40 and the RING finger domain of Retinoblastoma Binding Protein 6
… side effects of current chemotherapy treatments. Protein-protein interactions have recently come onto the scene as potential targets for novel treatment and management options for the disease. Through a yeast-two hybrid study, the RING finger domain of the Retinoblastoma binding protein 6 (RBBP6) …
-
Analysis of the biophysical and in silico exploration of the interaction between small ribonucleoprotein G and the RING finger domain of retinoblastoma binding protein 6 for the identification of protein anti-cancer compounds
… and develop cancer treatment methods using protein-protein interactions (PPIs) have become promising targets for therapeutic discovery. Suggestive evidence has proposed putative interactions between Small nuclear ribonucleoprotein polypeptide G (SNRPG) (also referred to as SmG in this study) …
-
Identifying Novel Interactions Between Human Ubiquitin-Specific Protease 7 (USP7) and Histone Methylating/Demethylating Proteins
… Protease 7 (USP7) is an indispensable protein responsible for regulating appropriate turnover of proteins involved in numerous signaling pathways and biological processes including immune response, DNA damage response, DNA replication, epigenetics and cell division. USP7s role in …
-
WDR5 Network Analysis Using Ensemble Approaches
<p>Understanding the properties of protein-protein interactions (PPIs) is necessary to deconvolute the processes inside living organisms. As such, research in this regard has significant implications for gaining insight into cancers and other diseases. Once understood, drugs can be designed to …
-
Alteration of differentiation and growth of normal human epidermal keratinocytes by benzo[a]pyrene and arsenic
… and growth. Altered genes include; α-integrin binding protein-63, interleukin-1α, interleukin-1β, Ras guanyl releasing protein-1, retinoic acid- and interferon-inducible protein, and YY1-associated factor-2. Arsenic altered the expression of genes involved in cell cycle checkpoint regulation. …
-
Recombinant expression, purification and structural characterization of aspergillus niger ring finger domain using nuclear magnetic resonance spectroscopy
e retinoblastoma binding protein 6 (RBBP6) is a 250 kDa nuclear protein which contains an N-terminal DWNN domain and a conserved RING finger domain. Previous studies determined the solution structure of the human RING finger domain using heteronuclear NMR spectroscopy. A bioinformatics analysis …
-
Characterisation and evolutionary dynamics of ten novel Gammapapillomavirus types from South African penile swabs
… (E1, E2, E4, E6 and E7) and two late (L1 and L2) proteins. Typical of Gamma-HPVs, the novel types all lacked the E5 ORF and HPV214 also lacked the E6 ORF. We further examined variation of the novel types in clinical specimens from which they were identified. All the clones of HPV211, HPV214, …